Academic Journal
View in EDS
HTML Full Text

SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study.

Bibliographic Details
Title: SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study.
Authors: Mahmoud, Mai A., Ayoub, Houssein H., Coyle, Peter, Tang, Patrick, Hasan, Mohammad R., Yassine, Hadi M., Al Thani, Asmaa A., Al‐Kanaani, Zaina, Al‐Kuwari, Einas, Jeremijenko, Andrew, Kaleeckal, Anvar Hassan, Latif, Ali Nizar, Shaik, Riyazuddin Mohammad, Abdul‐Rahim, Hanan F., Nasrallah, Gheyath K., Al‐Kuwari, Mohamed Ghaith, Butt, Adeel A., Al‐Romaihi, Hamad Eid, Al‐Thani, Mohamed H., Al‐Khal, Abdullatif
Source: Influenza & Other Respiratory Viruses; Nov2023, Vol. 17 Issue 11, p1-11, 11p
Subject Terms: COVID-19, SARS-CoV-2, OLDER people, BOOSTER vaccines, VACCINATION, COVID-19 pandemic
Geographic Terms: QATAR
Abstract: Background: We investigated the contribution of age, coexisting medical conditions, sex, and vaccination to incidence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and of severe, critical, or fatal COVID‐19 in older adults since pandemic onset. Methods: A national retrospective cohort study was conducted in the population of Qatar aged ≥50 years between February 5, 2020 and June 15, 2023. Adjusted hazard ratios (AHRs) for infection and for severe coronavirus disease 2019 (COVID‐19) outcomes were estimated through Cox regression models. Results: Cumulative incidence was 25.01% (95% confidence interval [CI]: 24.86–25.15%) for infection and 1.59% (95% CI: 1.55–1.64%) for severe, critical, or fatal COVID‐19 after a follow‐up duration of 40.9 months. Risk of infection varied minimally by age and sex but increased significantly with coexisting conditions. Risk of infection was reduced with primary‐series vaccination (AHR: 0.91, 95% CI: 0.90–0.93) and further with first booster vaccination (AHR: 0.75, 95% CI: 0.74–0.77). Risk of severe, critical, or fatal COVID‐19 increased exponentially with age and linearly with coexisting conditions. AHRs for severe, critical, or fatal COVID‐19 were 0.86 (95% CI: 0.7–0.97) for one dose, 0.15 (95% CI: 0.13–0.17) for primary‐series vaccination, and 0.11 (95% CI: 0.08–0.14) for first booster vaccination. Sensitivity analysis restricted to only Qataris yielded similar results. Conclusion: Incidence of severe COVID‐19 in older adults followed a dynamic pattern shaped by infection incidence, variant severity, and population immunity. Age, sex, and coexisting conditions were strong determinants of infection severity. Vaccine protection against severe outcomes showed a dose–response relationship, highlighting the importance of booster vaccination for older adults. [ABSTRACT FROM AUTHOR]
Copyright of Influenza & Other Respiratory Viruses is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edb&genre=article&issn=17502640&ISBN=&volume=17&issue=11&date=20231101&spage=1&pages=1-11&title=Influenza & Other Respiratory Viruses&atitle=SARS%E2%80%90CoV%E2%80%902%20infection%20and%20effects%20of%20age%2C%20sex%2C%20comorbidity%2C%20and%20vaccination%20among%20older%20individuals%3A%20A%20national%20cohort%20study.&aulast=Mahmoud%2C%20Mai%20A.&id=DOI:10.1111/irv.13224
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: edb
DbLabel: Complementary Index
An: 173925914
RelevancyScore: 983
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 983.153564453125
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Mahmoud%2C+Mai+A%2E%22">Mahmoud, Mai A.</searchLink><br /><searchLink fieldCode="AR" term="%22Ayoub%2C+Houssein+H%2E%22">Ayoub, Houssein H.</searchLink><br /><searchLink fieldCode="AR" term="%22Coyle%2C+Peter%22">Coyle, Peter</searchLink><br /><searchLink fieldCode="AR" term="%22Tang%2C+Patrick%22">Tang, Patrick</searchLink><br /><searchLink fieldCode="AR" term="%22Hasan%2C+Mohammad+R%2E%22">Hasan, Mohammad R.</searchLink><br /><searchLink fieldCode="AR" term="%22Yassine%2C+Hadi+M%2E%22">Yassine, Hadi M.</searchLink><br /><searchLink fieldCode="AR" term="%22Al+Thani%2C+Asmaa+A%2E%22">Al Thani, Asmaa A.</searchLink><br /><searchLink fieldCode="AR" term="%22Al‐Kanaani%2C+Zaina%22">Al‐Kanaani, Zaina</searchLink><br /><searchLink fieldCode="AR" term="%22Al‐Kuwari%2C+Einas%22">Al‐Kuwari, Einas</searchLink><br /><searchLink fieldCode="AR" term="%22Jeremijenko%2C+Andrew%22">Jeremijenko, Andrew</searchLink><br /><searchLink fieldCode="AR" term="%22Kaleeckal%2C+Anvar+Hassan%22">Kaleeckal, Anvar Hassan</searchLink><br /><searchLink fieldCode="AR" term="%22Latif%2C+Ali+Nizar%22">Latif, Ali Nizar</searchLink><br /><searchLink fieldCode="AR" term="%22Shaik%2C+Riyazuddin+Mohammad%22">Shaik, Riyazuddin Mohammad</searchLink><br /><searchLink fieldCode="AR" term="%22Abdul‐Rahim%2C+Hanan+F%2E%22">Abdul‐Rahim, Hanan F.</searchLink><br /><searchLink fieldCode="AR" term="%22Nasrallah%2C+Gheyath+K%2E%22">Nasrallah, Gheyath K.</searchLink><br /><searchLink fieldCode="AR" term="%22Al‐Kuwari%2C+Mohamed+Ghaith%22">Al‐Kuwari, Mohamed Ghaith</searchLink><br /><searchLink fieldCode="AR" term="%22Butt%2C+Adeel+A%2E%22">Butt, Adeel A.</searchLink><br /><searchLink fieldCode="AR" term="%22Al‐Romaihi%2C+Hamad+Eid%22">Al‐Romaihi, Hamad Eid</searchLink><br /><searchLink fieldCode="AR" term="%22Al‐Thani%2C+Mohamed+H%2E%22">Al‐Thani, Mohamed H.</searchLink><br /><searchLink fieldCode="AR" term="%22Al‐Khal%2C+Abdullatif%22">Al‐Khal, Abdullatif</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Influenza & Other Respiratory Viruses; Nov2023, Vol. 17 Issue 11, p1-11, 11p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22COVID-19%22">COVID-19</searchLink><br /><searchLink fieldCode="DE" term="%22SARS-CoV-2%22">SARS-CoV-2</searchLink><br /><searchLink fieldCode="DE" term="%22OLDER+people%22">OLDER people</searchLink><br /><searchLink fieldCode="DE" term="%22BOOSTER+vaccines%22">BOOSTER vaccines</searchLink><br /><searchLink fieldCode="DE" term="%22VACCINATION%22">VACCINATION</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19+pandemic%22">COVID-19 pandemic</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22QATAR%22">QATAR</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: We investigated the contribution of age, coexisting medical conditions, sex, and vaccination to incidence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and of severe, critical, or fatal COVID‐19 in older adults since pandemic onset. Methods: A national retrospective cohort study was conducted in the population of Qatar aged ≥50 years between February 5, 2020 and June 15, 2023. Adjusted hazard ratios (AHRs) for infection and for severe coronavirus disease 2019 (COVID‐19) outcomes were estimated through Cox regression models. Results: Cumulative incidence was 25.01% (95% confidence interval [CI]: 24.86–25.15%) for infection and 1.59% (95% CI: 1.55–1.64%) for severe, critical, or fatal COVID‐19 after a follow‐up duration of 40.9 months. Risk of infection varied minimally by age and sex but increased significantly with coexisting conditions. Risk of infection was reduced with primary‐series vaccination (AHR: 0.91, 95% CI: 0.90–0.93) and further with first booster vaccination (AHR: 0.75, 95% CI: 0.74–0.77). Risk of severe, critical, or fatal COVID‐19 increased exponentially with age and linearly with coexisting conditions. AHRs for severe, critical, or fatal COVID‐19 were 0.86 (95% CI: 0.7–0.97) for one dose, 0.15 (95% CI: 0.13–0.17) for primary‐series vaccination, and 0.11 (95% CI: 0.08–0.14) for first booster vaccination. Sensitivity analysis restricted to only Qataris yielded similar results. Conclusion: Incidence of severe COVID‐19 in older adults followed a dynamic pattern shaped by infection incidence, variant severity, and population immunity. Age, sex, and coexisting conditions were strong determinants of infection severity. Vaccine protection against severe outcomes showed a dose–response relationship, highlighting the importance of booster vaccination for older adults. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Influenza & Other Respiratory Viruses is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=173925914
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/irv.13224
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 1
    Subjects:
      – SubjectFull: QATAR
        Type: general
      – SubjectFull: COVID-19
        Type: general
      – SubjectFull: SARS-CoV-2
        Type: general
      – SubjectFull: OLDER people
        Type: general
      – SubjectFull: BOOSTER vaccines
        Type: general
      – SubjectFull: VACCINATION
        Type: general
      – SubjectFull: COVID-19 pandemic
        Type: general
    Titles:
      – TitleFull: SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Mahmoud, Mai A.
      – PersonEntity:
          Name:
            NameFull: Ayoub, Houssein H.
      – PersonEntity:
          Name:
            NameFull: Coyle, Peter
      – PersonEntity:
          Name:
            NameFull: Tang, Patrick
      – PersonEntity:
          Name:
            NameFull: Hasan, Mohammad R.
      – PersonEntity:
          Name:
            NameFull: Yassine, Hadi M.
      – PersonEntity:
          Name:
            NameFull: Al Thani, Asmaa A.
      – PersonEntity:
          Name:
            NameFull: Al‐Kanaani, Zaina
      – PersonEntity:
          Name:
            NameFull: Al‐Kuwari, Einas
      – PersonEntity:
          Name:
            NameFull: Jeremijenko, Andrew
      – PersonEntity:
          Name:
            NameFull: Kaleeckal, Anvar Hassan
      – PersonEntity:
          Name:
            NameFull: Latif, Ali Nizar
      – PersonEntity:
          Name:
            NameFull: Shaik, Riyazuddin Mohammad
      – PersonEntity:
          Name:
            NameFull: Abdul‐Rahim, Hanan F.
      – PersonEntity:
          Name:
            NameFull: Nasrallah, Gheyath K.
      – PersonEntity:
          Name:
            NameFull: Al‐Kuwari, Mohamed Ghaith
      – PersonEntity:
          Name:
            NameFull: Butt, Adeel A.
      – PersonEntity:
          Name:
            NameFull: Al‐Romaihi, Hamad Eid
      – PersonEntity:
          Name:
            NameFull: Al‐Thani, Mohamed H.
      – PersonEntity:
          Name:
            NameFull: Al‐Khal, Abdullatif
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: Nov2023
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 17502640
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: Influenza & Other Respiratory Viruses
              Type: main
ResultId 1