AST/ALT-to-platelet ratio (AARPRI) predicts gynaecological cancers: a 8-years follow-up study in 653 women.
| Title: | AST/ALT-to-platelet ratio (AARPRI) predicts gynaecological cancers: a 8-years follow-up study in 653 women. |
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| Authors: | Crudele, Lucilla, De Matteis, Carlo, Graziano, Giusi, Novielli, Fabio, Petruzzelli, Stefano, Piccinin, Elena, Gadaleta, Raffaella Maria, Cariello, Marica, Moschetta, Antonio |
| Source: | Scientific Reports; 11/20/2023, Vol. 13 Issue 1, p1-11, 11p |
| Subject Terms: | GYNECOLOGIC cancer, HEPATIC fibrosis, NON-alcoholic fatty liver disease, DISEASE risk factors, CARCINOGENESIS |
| Abstract: | Non-alcoholic fatty liver disease (NAFLD), specifically liver steatosis and fibrosis with steatohepatitis (NASH), is often associated with visceral adiposopathy, whose pathogenetic features have been proposed as tumorigenic triggers. We performed a prospective analysis in 653 metabolic women to reveal any conditions that may predict and concur to cancer development during a 8-years period of follow-up. Among clinical and biochemical variables, only AST and non-invasive liver fibrosis scores (AARPRI, APRI, FIB-4, mFIB4) significantly distinguished cancer-developer women (n = 62, 9.5%) from those who did not develop cancer (p < 0.001). In ROC analysis, these scores also showed good sensitivity and specificity in differentiating women who developed cancer (all p < 0.001). We then calculated OR for these indexes finding that increased AARPRI was associated with the highest risk (OR = 6, p < 0.001) of gynaecological cancers development. We further validated these cut-off values in women who had developed other types of cancer, confirming that AARPRI is able to identify the risk for cancer development (OR = 5, p < 0.001). Our findings support the hypothesis that NAFLD, more than obesity per se, is directly associated with the clinical and pathogenic metabolic scenario of gynaecological cancers and encourage the use of liver fibrosis indexes to detect risk of cancer onset in women. Preventing adiposopathy and NAFLD through lifestyle and therapies may represent an instrumental strategy for cancer prevention and/or co-treatment in oncology. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: AST/ALT-to-platelet ratio (AARPRI) predicts gynaecological cancers: a 8-years follow-up study in 653 women. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Crudele%2C+Lucilla%22">Crudele, Lucilla</searchLink><br /><searchLink fieldCode="AR" term="%22De+Matteis%2C+Carlo%22">De Matteis, Carlo</searchLink><br /><searchLink fieldCode="AR" term="%22Graziano%2C+Giusi%22">Graziano, Giusi</searchLink><br /><searchLink fieldCode="AR" term="%22Novielli%2C+Fabio%22">Novielli, Fabio</searchLink><br /><searchLink fieldCode="AR" term="%22Petruzzelli%2C+Stefano%22">Petruzzelli, Stefano</searchLink><br /><searchLink fieldCode="AR" term="%22Piccinin%2C+Elena%22">Piccinin, Elena</searchLink><br /><searchLink fieldCode="AR" term="%22Gadaleta%2C+Raffaella+Maria%22">Gadaleta, Raffaella Maria</searchLink><br /><searchLink fieldCode="AR" term="%22Cariello%2C+Marica%22">Cariello, Marica</searchLink><br /><searchLink fieldCode="AR" term="%22Moschetta%2C+Antonio%22">Moschetta, Antonio</searchLink> – Name: TitleSource Label: Source Group: Src Data: Scientific Reports; 11/20/2023, Vol. 13 Issue 1, p1-11, 11p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22GYNECOLOGIC+cancer%22">GYNECOLOGIC cancer</searchLink><br /><searchLink fieldCode="DE" term="%22HEPATIC+fibrosis%22">HEPATIC fibrosis</searchLink><br /><searchLink fieldCode="DE" term="%22NON-alcoholic+fatty+liver+disease%22">NON-alcoholic fatty liver disease</searchLink><br /><searchLink fieldCode="DE" term="%22DISEASE+risk+factors%22">DISEASE risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22CARCINOGENESIS%22">CARCINOGENESIS</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Non-alcoholic fatty liver disease (NAFLD), specifically liver steatosis and fibrosis with steatohepatitis (NASH), is often associated with visceral adiposopathy, whose pathogenetic features have been proposed as tumorigenic triggers. We performed a prospective analysis in 653 metabolic women to reveal any conditions that may predict and concur to cancer development during a 8-years period of follow-up. Among clinical and biochemical variables, only AST and non-invasive liver fibrosis scores (AARPRI, APRI, FIB-4, mFIB4) significantly distinguished cancer-developer women (n = 62, 9.5%) from those who did not develop cancer (p < 0.001). In ROC analysis, these scores also showed good sensitivity and specificity in differentiating women who developed cancer (all p < 0.001). We then calculated OR for these indexes finding that increased AARPRI was associated with the highest risk (OR = 6, p < 0.001) of gynaecological cancers development. We further validated these cut-off values in women who had developed other types of cancer, confirming that AARPRI is able to identify the risk for cancer development (OR = 5, p < 0.001). Our findings support the hypothesis that NAFLD, more than obesity per se, is directly associated with the clinical and pathogenic metabolic scenario of gynaecological cancers and encourage the use of liver fibrosis indexes to detect risk of cancer onset in women. Preventing adiposopathy and NAFLD through lifestyle and therapies may represent an instrumental strategy for cancer prevention and/or co-treatment in oncology. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41598-023-44243-y Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1 Subjects: – SubjectFull: GYNECOLOGIC cancer Type: general – SubjectFull: HEPATIC fibrosis Type: general – SubjectFull: NON-alcoholic fatty liver disease Type: general – SubjectFull: DISEASE risk factors Type: general – SubjectFull: CARCINOGENESIS Type: general Titles: – TitleFull: AST/ALT-to-platelet ratio (AARPRI) predicts gynaecological cancers: a 8-years follow-up study in 653 women. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Crudele, Lucilla – PersonEntity: Name: NameFull: De Matteis, Carlo – PersonEntity: Name: NameFull: Graziano, Giusi – PersonEntity: Name: NameFull: Novielli, Fabio – PersonEntity: Name: NameFull: Petruzzelli, Stefano – PersonEntity: Name: NameFull: Piccinin, Elena – PersonEntity: Name: NameFull: Gadaleta, Raffaella Maria – PersonEntity: Name: NameFull: Cariello, Marica – PersonEntity: Name: NameFull: Moschetta, Antonio IsPartOfRelationships: – BibEntity: Dates: – D: 20 M: 11 Text: 11/20/2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 20452322 Numbering: – Type: volume Value: 13 – Type: issue Value: 1 Titles: – TitleFull: Scientific Reports Type: main |
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