Real‐world practice of Helicobacter pylori management: A survey among physicians in Southeast Asia.
| Title: | Real‐world practice of Helicobacter pylori management: A survey among physicians in Southeast Asia. |
|---|---|
| Authors: | Quach, Duc Trong, Vilaichone, Ratha‐korn, Luu, Mai Ngoc, Lee, Yeong Yeh, Ang, Tiing Leong, Miftahussurur, Muhammad, Aye, Than Than, Basir, Dewi Norwani, Vutha, Ky, Vannarath, Sengdao, Sollano, Jose D., Mahachai, Varocha |
| Source: | Helicobacter; Dec2023, Vol. 28 Issue 6, p1-10, 10p |
| Subject Terms: | HELICOBACTER pylori, PHYSICIANS, MICROBIAL sensitivity tests, PROTON pump inhibitors, CLARITHROMYCIN, GASTROENTEROLOGISTS |
| Geographic Terms: | SOUTHEAST Asia |
| Abstract: | Background: Multidrug‐resistant Helicobacter pylori strains are emerging in Southeast Asia. This study evaluates the region's real‐world practice in H. pylori management. Materials and Methods: Physicians who managed H. pylori eradication in daily practice across 10 Southeast Asian countries were invited to participate in an online questionnaire, which included questions about the local availability of antimicrobial susceptibility tests (ASTs) and their preferred eradication regimens in real‐world practice. An empiric regimen was considered inappropriate if it did not follow the local guidelines/consensus, particularly if it contained antibiotics with a high reported resistance rate or was recommended not to be empirically used worldwide. Results: There were 564 valid responses, including 314 (55.7%) from gastroenterologists (GIs) and 250 (44.3%) from non‐GI physicians. ASTs were unavailable in 41.7%. In countries with low and intermediate clarithromycin resistance, the most common first‐line regimen was PAC (proton pump inhibitor [PPI], amoxicillin, clarithromycin) (72.7% and 73.2%, respectively). Regarding second‐line therapy, the most common regimen was bismuth‐based quadruple therapy, PBMT (PPI, bismuth, metronidazole, tetracycline) (50.0% and 59.8%, respectively), if other regimens were used as first‐line treatment. Concomitant therapy (PPI, amoxicillin, clarithromycin, metronidazole) (30.5% and 25.9%, respectively) and PAL (PPI, amoxicillin, levofloxacin) (22.7% and 27.7%, respectively) were favored if PBMT had been used as first‐line treatment. In countries with high clarithromycin resistance, the most common first‐line regimen was PBMT, but the utilization rate was only 57.7%. Alarmingly, PAC was prescribed in 27.8% of patients, ranking as the second most common regimen, and its prescription rate was higher in non‐GI physicians than GI physicians (40.1% vs. 16.2%, p < 0.001). Conclusions: Choosing inappropriate regimens containing antibiotics with high resistance rates is not uncommon in Southeast Asia, especially among non‐GI physicians. In countries with high clarithromycin resistance, the PBMT regimen is underutilized. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Real‐world practice of Helicobacter pylori management: A survey among physicians in Southeast Asia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Quach%2C+Duc+Trong%22">Quach, Duc Trong</searchLink><br /><searchLink fieldCode="AR" term="%22Vilaichone%2C+Ratha‐korn%22">Vilaichone, Ratha‐korn</searchLink><br /><searchLink fieldCode="AR" term="%22Luu%2C+Mai+Ngoc%22">Luu, Mai Ngoc</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Yeong+Yeh%22">Lee, Yeong Yeh</searchLink><br /><searchLink fieldCode="AR" term="%22Ang%2C+Tiing+Leong%22">Ang, Tiing Leong</searchLink><br /><searchLink fieldCode="AR" term="%22Miftahussurur%2C+Muhammad%22">Miftahussurur, Muhammad</searchLink><br /><searchLink fieldCode="AR" term="%22Aye%2C+Than+Than%22">Aye, Than Than</searchLink><br /><searchLink fieldCode="AR" term="%22Basir%2C+Dewi+Norwani%22">Basir, Dewi Norwani</searchLink><br /><searchLink fieldCode="AR" term="%22Vutha%2C+Ky%22">Vutha, Ky</searchLink><br /><searchLink fieldCode="AR" term="%22Vannarath%2C+Sengdao%22">Vannarath, Sengdao</searchLink><br /><searchLink fieldCode="AR" term="%22Sollano%2C+Jose+D%2E%22">Sollano, Jose D.</searchLink><br /><searchLink fieldCode="AR" term="%22Mahachai%2C+Varocha%22">Mahachai, Varocha</searchLink> – Name: TitleSource Label: Source Group: Src Data: Helicobacter; Dec2023, Vol. 28 Issue 6, p1-10, 10p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22HELICOBACTER+pylori%22">HELICOBACTER pylori</searchLink><br /><searchLink fieldCode="DE" term="%22PHYSICIANS%22">PHYSICIANS</searchLink><br /><searchLink fieldCode="DE" term="%22MICROBIAL+sensitivity+tests%22">MICROBIAL sensitivity tests</searchLink><br /><searchLink fieldCode="DE" term="%22PROTON+pump+inhibitors%22">PROTON pump inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22CLARITHROMYCIN%22">CLARITHROMYCIN</searchLink><br /><searchLink fieldCode="DE" term="%22GASTROENTEROLOGISTS%22">GASTROENTEROLOGISTS</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22SOUTHEAST+Asia%22">SOUTHEAST Asia</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Multidrug‐resistant Helicobacter pylori strains are emerging in Southeast Asia. This study evaluates the region's real‐world practice in H. pylori management. Materials and Methods: Physicians who managed H. pylori eradication in daily practice across 10 Southeast Asian countries were invited to participate in an online questionnaire, which included questions about the local availability of antimicrobial susceptibility tests (ASTs) and their preferred eradication regimens in real‐world practice. An empiric regimen was considered inappropriate if it did not follow the local guidelines/consensus, particularly if it contained antibiotics with a high reported resistance rate or was recommended not to be empirically used worldwide. Results: There were 564 valid responses, including 314 (55.7%) from gastroenterologists (GIs) and 250 (44.3%) from non‐GI physicians. ASTs were unavailable in 41.7%. In countries with low and intermediate clarithromycin resistance, the most common first‐line regimen was PAC (proton pump inhibitor [PPI], amoxicillin, clarithromycin) (72.7% and 73.2%, respectively). Regarding second‐line therapy, the most common regimen was bismuth‐based quadruple therapy, PBMT (PPI, bismuth, metronidazole, tetracycline) (50.0% and 59.8%, respectively), if other regimens were used as first‐line treatment. Concomitant therapy (PPI, amoxicillin, clarithromycin, metronidazole) (30.5% and 25.9%, respectively) and PAL (PPI, amoxicillin, levofloxacin) (22.7% and 27.7%, respectively) were favored if PBMT had been used as first‐line treatment. In countries with high clarithromycin resistance, the most common first‐line regimen was PBMT, but the utilization rate was only 57.7%. Alarmingly, PAC was prescribed in 27.8% of patients, ranking as the second most common regimen, and its prescription rate was higher in non‐GI physicians than GI physicians (40.1% vs. 16.2%, p < 0.001). Conclusions: Choosing inappropriate regimens containing antibiotics with high resistance rates is not uncommon in Southeast Asia, especially among non‐GI physicians. In countries with high clarithromycin resistance, the PBMT regimen is underutilized. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Helicobacter is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/hel.13018 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 1 Subjects: – SubjectFull: SOUTHEAST Asia Type: general – SubjectFull: HELICOBACTER pylori Type: general – SubjectFull: PHYSICIANS Type: general – SubjectFull: MICROBIAL sensitivity tests Type: general – SubjectFull: PROTON pump inhibitors Type: general – SubjectFull: CLARITHROMYCIN Type: general – SubjectFull: GASTROENTEROLOGISTS Type: general Titles: – TitleFull: Real‐world practice of Helicobacter pylori management: A survey among physicians in Southeast Asia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Quach, Duc Trong – PersonEntity: Name: NameFull: Vilaichone, Ratha‐korn – PersonEntity: Name: NameFull: Luu, Mai Ngoc – PersonEntity: Name: NameFull: Lee, Yeong Yeh – PersonEntity: Name: NameFull: Ang, Tiing Leong – PersonEntity: Name: NameFull: Miftahussurur, Muhammad – PersonEntity: Name: NameFull: Aye, Than Than – PersonEntity: Name: NameFull: Basir, Dewi Norwani – PersonEntity: Name: NameFull: Vutha, Ky – PersonEntity: Name: NameFull: Vannarath, Sengdao – PersonEntity: Name: NameFull: Sollano, Jose D. – PersonEntity: Name: NameFull: Mahachai, Varocha IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 10834389 Numbering: – Type: volume Value: 28 – Type: issue Value: 6 Titles: – TitleFull: Helicobacter Type: main |
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