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Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes.

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Title: Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes.
Authors: Hirvonen, M. Karoliina, Lietzén, Niina, Moulder, Robert, Bhosale, Santosh D., Koskenniemi, Jaakko, Vähä-Mäkilä, Mari, Nurmio, Mirja, Orešič, Matej, Ilonen, Jorma, Toppari, Jorma, Veijola, Riitta, Hyöty, Heikki, Lähdesmäki, Harri, Knip, Mikael, Cheng, Lu, Lahesmaa, Riitta
Source: Scientific Reports; 11/18/2023, Vol. 13 Issue 1, p1-11, 11p
Subject Terms: TYPE 1 diabetes, AUTOANTIBODIES, APOLIPOPROTEIN C, PANCREATIC beta cells, PANEL analysis, PROTEOMICS
Abstract: Better understanding of the early events in the development of type 1 diabetes is needed to improve prediction and monitoring of the disease progression during the substantially heterogeneous presymptomatic period of the beta cell damaging process. To address this concern, we used mass spectrometry-based proteomics to analyse longitudinal pre-onset plasma sample series from children positive for multiple islet autoantibodies who had rapidly progressed to type 1 diabetes before 4 years of age (n = 10) and compared these with similar measurements from matched children who were either positive for a single autoantibody (n = 10) or autoantibody negative (n = 10). Following statistical analysis of the longitudinal data, targeted serum proteomics was used to verify 11 proteins putatively associated with the disease development in a similar yet independent and larger cohort of children who progressed to the disease within 5 years of age (n = 31) and matched autoantibody negative children (n = 31). These data reiterated extensive age-related trends for protein levels in young children. Further, these analyses demonstrated that the serum levels of two peptides unique for apolipoprotein C1 (APOC1) were decreased after the appearance of the first islet autoantibody and remained relatively less abundant in children who progressed to type 1 diabetes, in comparison to autoantibody negative children. [ABSTRACT FROM AUTHOR]
Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
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  Data: Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Hirvonen%2C+M%2E+Karoliina%22">Hirvonen, M. Karoliina</searchLink><br /><searchLink fieldCode="AR" term="%22Lietzén%2C+Niina%22">Lietzén, Niina</searchLink><br /><searchLink fieldCode="AR" term="%22Moulder%2C+Robert%22">Moulder, Robert</searchLink><br /><searchLink fieldCode="AR" term="%22Bhosale%2C+Santosh+D%2E%22">Bhosale, Santosh D.</searchLink><br /><searchLink fieldCode="AR" term="%22Koskenniemi%2C+Jaakko%22">Koskenniemi, Jaakko</searchLink><br /><searchLink fieldCode="AR" term="%22Vähä-Mäkilä%2C+Mari%22">Vähä-Mäkilä, Mari</searchLink><br /><searchLink fieldCode="AR" term="%22Nurmio%2C+Mirja%22">Nurmio, Mirja</searchLink><br /><searchLink fieldCode="AR" term="%22Orešič%2C+Matej%22">Orešič, Matej</searchLink><br /><searchLink fieldCode="AR" term="%22Ilonen%2C+Jorma%22">Ilonen, Jorma</searchLink><br /><searchLink fieldCode="AR" term="%22Toppari%2C+Jorma%22">Toppari, Jorma</searchLink><br /><searchLink fieldCode="AR" term="%22Veijola%2C+Riitta%22">Veijola, Riitta</searchLink><br /><searchLink fieldCode="AR" term="%22Hyöty%2C+Heikki%22">Hyöty, Heikki</searchLink><br /><searchLink fieldCode="AR" term="%22Lähdesmäki%2C+Harri%22">Lähdesmäki, Harri</searchLink><br /><searchLink fieldCode="AR" term="%22Knip%2C+Mikael%22">Knip, Mikael</searchLink><br /><searchLink fieldCode="AR" term="%22Cheng%2C+Lu%22">Cheng, Lu</searchLink><br /><searchLink fieldCode="AR" term="%22Lahesmaa%2C+Riitta%22">Lahesmaa, Riitta</searchLink>
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  Data: Scientific Reports; 11/18/2023, Vol. 13 Issue 1, p1-11, 11p
– Name: Subject
  Label: Subject Terms
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  Data: <searchLink fieldCode="DE" term="%22TYPE+1+diabetes%22">TYPE 1 diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22AUTOANTIBODIES%22">AUTOANTIBODIES</searchLink><br /><searchLink fieldCode="DE" term="%22APOLIPOPROTEIN+C%22">APOLIPOPROTEIN C</searchLink><br /><searchLink fieldCode="DE" term="%22PANCREATIC+beta+cells%22">PANCREATIC beta cells</searchLink><br /><searchLink fieldCode="DE" term="%22PANEL+analysis%22">PANEL analysis</searchLink><br /><searchLink fieldCode="DE" term="%22PROTEOMICS%22">PROTEOMICS</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Better understanding of the early events in the development of type 1 diabetes is needed to improve prediction and monitoring of the disease progression during the substantially heterogeneous presymptomatic period of the beta cell damaging process. To address this concern, we used mass spectrometry-based proteomics to analyse longitudinal pre-onset plasma sample series from children positive for multiple islet autoantibodies who had rapidly progressed to type 1 diabetes before 4 years of age (n = 10) and compared these with similar measurements from matched children who were either positive for a single autoantibody (n = 10) or autoantibody negative (n = 10). Following statistical analysis of the longitudinal data, targeted serum proteomics was used to verify 11 proteins putatively associated with the disease development in a similar yet independent and larger cohort of children who progressed to the disease within 5 years of age (n = 31) and matched autoantibody negative children (n = 31). These data reiterated extensive age-related trends for protein levels in young children. Further, these analyses demonstrated that the serum levels of two peptides unique for apolipoprotein C1 (APOC1) were decreased after the appearance of the first islet autoantibody and remained relatively less abundant in children who progressed to type 1 diabetes, in comparison to autoantibody negative children. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1038/s41598-023-43039-4
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        Text: English
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      – SubjectFull: TYPE 1 diabetes
        Type: general
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