High incidence of catheter-associated urinary tract infections and related antibiotic resistance in two hospitals of different geographic regions of Sierra Leone: a prospective cohort study.
| Title: | High incidence of catheter-associated urinary tract infections and related antibiotic resistance in two hospitals of different geographic regions of Sierra Leone: a prospective cohort study. |
|---|---|
| Authors: | Lakoh, Sulaiman, Yi, Le, Russell, James B.W., Zhang, Juling, Sevalie, Stephen, Zhao, Yongkun, Kanu, Joseph Sam, Liu, Peng, Conteh, Sarah K., Williams, Christine Ellen Elleanor, Barrie, Umu, Adekanmbi, Olukemi, Jiba, Darlinda F., Kamara, Matilda N., Sesay, Daniel, Deen, Gibrilla F., Okeibunor, Joseph Chukwudi, Yendewa, George A., Guo, Xuejun, Firima, Emmanuel |
| Source: | BMC Research Notes; 10/31/2023, Vol. 16 Issue 1, p1-8, 8p |
| Subject Terms: | CATHETER-associated urinary tract infections, ENTEROBACTERIACEAE, AMIKACIN, DRUG resistance in bacteria, DIAGNOSTIC microbiology, ESCHERICHIA coli, COHORT analysis |
| Geographic Terms: | SIERRA Leone |
| Abstract: | Objective: Catheter-associated urinary tract infections (CAUTI) are common worldwide, but due to limited resources, its actual burden in low-income countries is unknown. Currently, there are gaps in knowledge about CAUTI due to lack of surveillance activities in Sierra Leone. In this prospective cohort study, we aimed to determine the incidence of CAUTI and associated antibiotic resistance in two tertiary hospitals in different regions of Sierra Leone. Results: The mean age of the 459 recruited patients was 48.8 years. The majority were females (236, 51.3%). Amongst the 196 (42.6%) catheterized patients, 29 (14.8%) developed CAUTI. Bacterial growth was reported in 32 (84%) patients. Escherichia coli (14, 23.7%), Klebsiella pneumoniae (10, 17.0%), and Klebsiella oxytoca (8, 13.6%) were the most common isolates. Most isolates were ESBL-producing Enterobacteriaceae (33, 56%) and WHO Priority 1 (Critical) pathogens (38, 71%). Resistance of K. pneumoniae, K. oxytoca, E. coli, and Proteus mirabilis was higher with the third-generation cephalosporins and penicillins but lower with carbapenems, piperacillin-tazobactam and amikacin. To reduce the high incidence of CAUTI and multi-drug resistance organisms, urgent action is needed to strengthen the microbiology diagnostic services and develop and implement catheter bundles that provide clear guidance for catheter insertion, care and removal. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: High incidence of catheter-associated urinary tract infections and related antibiotic resistance in two hospitals of different geographic regions of Sierra Leone: a prospective cohort study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lakoh%2C+Sulaiman%22">Lakoh, Sulaiman</searchLink><br /><searchLink fieldCode="AR" term="%22Yi%2C+Le%22">Yi, Le</searchLink><br /><searchLink fieldCode="AR" term="%22Russell%2C+James+B%2EW%2E%22">Russell, James B.W.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Juling%22">Zhang, Juling</searchLink><br /><searchLink fieldCode="AR" term="%22Sevalie%2C+Stephen%22">Sevalie, Stephen</searchLink><br /><searchLink fieldCode="AR" term="%22Zhao%2C+Yongkun%22">Zhao, Yongkun</searchLink><br /><searchLink fieldCode="AR" term="%22Kanu%2C+Joseph+Sam%22">Kanu, Joseph Sam</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Peng%22">Liu, Peng</searchLink><br /><searchLink fieldCode="AR" term="%22Conteh%2C+Sarah+K%2E%22">Conteh, Sarah K.</searchLink><br /><searchLink fieldCode="AR" term="%22Williams%2C+Christine+Ellen+Elleanor%22">Williams, Christine Ellen Elleanor</searchLink><br /><searchLink fieldCode="AR" term="%22Barrie%2C+Umu%22">Barrie, Umu</searchLink><br /><searchLink fieldCode="AR" term="%22Adekanmbi%2C+Olukemi%22">Adekanmbi, Olukemi</searchLink><br /><searchLink fieldCode="AR" term="%22Jiba%2C+Darlinda+F%2E%22">Jiba, Darlinda F.</searchLink><br /><searchLink fieldCode="AR" term="%22Kamara%2C+Matilda+N%2E%22">Kamara, Matilda N.</searchLink><br /><searchLink fieldCode="AR" term="%22Sesay%2C+Daniel%22">Sesay, Daniel</searchLink><br /><searchLink fieldCode="AR" term="%22Deen%2C+Gibrilla+F%2E%22">Deen, Gibrilla F.</searchLink><br /><searchLink fieldCode="AR" term="%22Okeibunor%2C+Joseph+Chukwudi%22">Okeibunor, Joseph Chukwudi</searchLink><br /><searchLink fieldCode="AR" term="%22Yendewa%2C+George+A%2E%22">Yendewa, George A.</searchLink><br /><searchLink fieldCode="AR" term="%22Guo%2C+Xuejun%22">Guo, Xuejun</searchLink><br /><searchLink fieldCode="AR" term="%22Firima%2C+Emmanuel%22">Firima, Emmanuel</searchLink> – Name: TitleSource Label: Source Group: Src Data: BMC Research Notes; 10/31/2023, Vol. 16 Issue 1, p1-8, 8p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22CATHETER-associated+urinary+tract+infections%22">CATHETER-associated urinary tract infections</searchLink><br /><searchLink fieldCode="DE" term="%22ENTEROBACTERIACEAE%22">ENTEROBACTERIACEAE</searchLink><br /><searchLink fieldCode="DE" term="%22AMIKACIN%22">AMIKACIN</searchLink><br /><searchLink fieldCode="DE" term="%22DRUG+resistance+in+bacteria%22">DRUG resistance in bacteria</searchLink><br /><searchLink fieldCode="DE" term="%22DIAGNOSTIC+microbiology%22">DIAGNOSTIC microbiology</searchLink><br /><searchLink fieldCode="DE" term="%22ESCHERICHIA+coli%22">ESCHERICHIA coli</searchLink><br /><searchLink fieldCode="DE" term="%22COHORT+analysis%22">COHORT analysis</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22SIERRA+Leone%22">SIERRA Leone</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective: Catheter-associated urinary tract infections (CAUTI) are common worldwide, but due to limited resources, its actual burden in low-income countries is unknown. Currently, there are gaps in knowledge about CAUTI due to lack of surveillance activities in Sierra Leone. In this prospective cohort study, we aimed to determine the incidence of CAUTI and associated antibiotic resistance in two tertiary hospitals in different regions of Sierra Leone. Results: The mean age of the 459 recruited patients was 48.8 years. The majority were females (236, 51.3%). Amongst the 196 (42.6%) catheterized patients, 29 (14.8%) developed CAUTI. Bacterial growth was reported in 32 (84%) patients. Escherichia coli (14, 23.7%), Klebsiella pneumoniae (10, 17.0%), and Klebsiella oxytoca (8, 13.6%) were the most common isolates. Most isolates were ESBL-producing Enterobacteriaceae (33, 56%) and WHO Priority 1 (Critical) pathogens (38, 71%). Resistance of K. pneumoniae, K. oxytoca, E. coli, and Proteus mirabilis was higher with the third-generation cephalosporins and penicillins but lower with carbapenems, piperacillin-tazobactam and amikacin. To reduce the high incidence of CAUTI and multi-drug resistance organisms, urgent action is needed to strengthen the microbiology diagnostic services and develop and implement catheter bundles that provide clear guidance for catheter insertion, care and removal. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of BMC Research Notes is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s13104-023-06591-w Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 1 Subjects: – SubjectFull: SIERRA Leone Type: general – SubjectFull: CATHETER-associated urinary tract infections Type: general – SubjectFull: ENTEROBACTERIACEAE Type: general – SubjectFull: AMIKACIN Type: general – SubjectFull: DRUG resistance in bacteria Type: general – SubjectFull: DIAGNOSTIC microbiology Type: general – SubjectFull: ESCHERICHIA coli Type: general – SubjectFull: COHORT analysis Type: general Titles: – TitleFull: High incidence of catheter-associated urinary tract infections and related antibiotic resistance in two hospitals of different geographic regions of Sierra Leone: a prospective cohort study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lakoh, Sulaiman – PersonEntity: Name: NameFull: Yi, Le – PersonEntity: Name: NameFull: Russell, James B.W. – PersonEntity: Name: NameFull: Zhang, Juling – PersonEntity: Name: NameFull: Sevalie, Stephen – PersonEntity: Name: NameFull: Zhao, Yongkun – PersonEntity: Name: NameFull: Kanu, Joseph Sam – PersonEntity: Name: NameFull: Liu, Peng – PersonEntity: Name: NameFull: Conteh, Sarah K. – PersonEntity: Name: NameFull: Williams, Christine Ellen Elleanor – PersonEntity: Name: NameFull: Barrie, Umu – PersonEntity: Name: NameFull: Adekanmbi, Olukemi – PersonEntity: Name: NameFull: Jiba, Darlinda F. – PersonEntity: Name: NameFull: Kamara, Matilda N. – PersonEntity: Name: NameFull: Sesay, Daniel – PersonEntity: Name: NameFull: Deen, Gibrilla F. – PersonEntity: Name: NameFull: Okeibunor, Joseph Chukwudi – PersonEntity: Name: NameFull: Yendewa, George A. – PersonEntity: Name: NameFull: Guo, Xuejun – PersonEntity: Name: NameFull: Firima, Emmanuel IsPartOfRelationships: – BibEntity: Dates: – D: 31 M: 10 Text: 10/31/2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 17560500 Numbering: – Type: volume Value: 16 – Type: issue Value: 1 Titles: – TitleFull: BMC Research Notes Type: main |
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