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Antioxidant, Antiglaucoma, Anticholinergic, and Antidiabetic Effects of Kiwifruit (Actinidia deliciosa) Oil: Metabolite Profile Analysis Using LC-HR/MS, GC/MS and GC-FID.

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Title: Antioxidant, Antiglaucoma, Anticholinergic, and Antidiabetic Effects of Kiwifruit (Actinidia deliciosa) Oil: Metabolite Profile Analysis Using LC-HR/MS, GC/MS and GC-FID.
Authors: Ozden, Eda Mehtap, Bingol, Zeynebe, Mutlu, Muzaffer, Karagecili, Hasan, Köksal, Ekrem, Goren, Ahmet C., Alwasel, Saleh H., Gulcin, İlhami
Source: Life (2075-1729); Sep2023, Vol. 13 Issue 9, p1939, 20p
Subject Terms: KIWIFRUIT, ACTINIDIA, VEGETABLE oils, PETROLEUM, ESSENTIAL oils, ACETYLCHOLINESTERASE, CARYOPHYLLENE
Abstract: Determining the antioxidant abilities and enzyme inhibition profiles of medicinally important plants and their oils is of great importance for a healthy life and the treatment of some common global diseases. Kiwifruit (Actinidia deliciosa) oil was examined and researched using several bioanalytical methods comprehensively for the first time in this research to determine its antioxidant, antiglaucoma, antidiabetic and anti-Alzheimer's capabilities. Additionally, the kiwifruit oil inhibitory effects on acetylcholinesterase (AChE), carbonic anhydrase II (CA II), and α-amylase, which are linked to a number of metabolic illnesses, were established. Furthermore, LC-HRMS analysis was used to assess the phenolic content of kiwifruit oil. It came to light that kiwifruit oil contained 26 different phenolic compounds. According to the LC-HRMS findings, kiwifruit oil is abundant in apigenin (74.24 mg/L oil), epigallocatechin (12.89 mg/L oil), caryophyllene oxide (12.89 mg/L oil), and luteolin (5.49 mg/L oil). In addition, GC-MS and GC-FID studies were used to ascertain the quantity and chemical composition of the essential oils contained in kiwifruit oil. Squalene (53.04%), linoleoyl chloride (20.28%), linoleic acid (2.67%), and palmitic acid (1.54%) were the most abundant compounds in kiwifruit oil. For radical scavenging activities of kiwifruit oil, 1,1-diphenyl-2-picryl-hydrazil (DPPH•) and 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS•+) radicals scavenging techniques were examined. These methods effectively demonstrated the potent radical scavenging properties of kiwifruit oil (IC50: 48.55 μg/mL for DPPH•, and IC50: 77.00 μg/mL for ABTS•+ scavenging). Also, for reducing capabilities, iron (Fe3+), copper (Cu2+), and Fe3+-2,4,6-tri(2-pyridyl)-S-triazine (TPTZ) reducing abilities were studied. Moreover, kiwifruit oil showed a considerable inhibition effect towards hCA II (IC50: 505.83 μg/mL), AChE (IC50: 12.80 μg/mL), and α-amylase (IC50: 421.02 μg/mL). The results revealed that the use of kiwifruit oil in a pharmaceutical procedure has very important effects due to its antioxidant, anti-Alzheimer, antidiabetic, and antiglaucoma effects. [ABSTRACT FROM AUTHOR]
Copyright of Life (2075-1729) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
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  Label: Title
  Group: Ti
  Data: Antioxidant, Antiglaucoma, Anticholinergic, and Antidiabetic Effects of Kiwifruit (Actinidia deliciosa) Oil: Metabolite Profile Analysis Using LC-HR/MS, GC/MS and GC-FID.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Ozden%2C+Eda+Mehtap%22">Ozden, Eda Mehtap</searchLink><br /><searchLink fieldCode="AR" term="%22Bingol%2C+Zeynebe%22">Bingol, Zeynebe</searchLink><br /><searchLink fieldCode="AR" term="%22Mutlu%2C+Muzaffer%22">Mutlu, Muzaffer</searchLink><br /><searchLink fieldCode="AR" term="%22Karagecili%2C+Hasan%22">Karagecili, Hasan</searchLink><br /><searchLink fieldCode="AR" term="%22Köksal%2C+Ekrem%22">Köksal, Ekrem</searchLink><br /><searchLink fieldCode="AR" term="%22Goren%2C+Ahmet+C%2E%22">Goren, Ahmet C.</searchLink><br /><searchLink fieldCode="AR" term="%22Alwasel%2C+Saleh+H%2E%22">Alwasel, Saleh H.</searchLink><br /><searchLink fieldCode="AR" term="%22Gulcin%2C+İlhami%22">Gulcin, İlhami</searchLink>
– Name: TitleSource
  Label: Source
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  Data: Life (2075-1729); Sep2023, Vol. 13 Issue 9, p1939, 20p
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22KIWIFRUIT%22">KIWIFRUIT</searchLink><br /><searchLink fieldCode="DE" term="%22ACTINIDIA%22">ACTINIDIA</searchLink><br /><searchLink fieldCode="DE" term="%22VEGETABLE+oils%22">VEGETABLE oils</searchLink><br /><searchLink fieldCode="DE" term="%22PETROLEUM%22">PETROLEUM</searchLink><br /><searchLink fieldCode="DE" term="%22ESSENTIAL+oils%22">ESSENTIAL oils</searchLink><br /><searchLink fieldCode="DE" term="%22ACETYLCHOLINESTERASE%22">ACETYLCHOLINESTERASE</searchLink><br /><searchLink fieldCode="DE" term="%22CARYOPHYLLENE%22">CARYOPHYLLENE</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Determining the antioxidant abilities and enzyme inhibition profiles of medicinally important plants and their oils is of great importance for a healthy life and the treatment of some common global diseases. Kiwifruit (Actinidia deliciosa) oil was examined and researched using several bioanalytical methods comprehensively for the first time in this research to determine its antioxidant, antiglaucoma, antidiabetic and anti-Alzheimer's capabilities. Additionally, the kiwifruit oil inhibitory effects on acetylcholinesterase (AChE), carbonic anhydrase II (CA II), and α-amylase, which are linked to a number of metabolic illnesses, were established. Furthermore, LC-HRMS analysis was used to assess the phenolic content of kiwifruit oil. It came to light that kiwifruit oil contained 26 different phenolic compounds. According to the LC-HRMS findings, kiwifruit oil is abundant in apigenin (74.24 mg/L oil), epigallocatechin (12.89 mg/L oil), caryophyllene oxide (12.89 mg/L oil), and luteolin (5.49 mg/L oil). In addition, GC-MS and GC-FID studies were used to ascertain the quantity and chemical composition of the essential oils contained in kiwifruit oil. Squalene (53.04%), linoleoyl chloride (20.28%), linoleic acid (2.67%), and palmitic acid (1.54%) were the most abundant compounds in kiwifruit oil. For radical scavenging activities of kiwifruit oil, 1,1-diphenyl-2-picryl-hydrazil (DPPH<superscript>•</superscript>) and 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS<superscript>•+</superscript>) radicals scavenging techniques were examined. These methods effectively demonstrated the potent radical scavenging properties of kiwifruit oil (IC<subscript>50</subscript>: 48.55 μg/mL for DPPH<superscript>•</superscript>, and IC<subscript>50</subscript>: 77.00 μg/mL for ABTS<superscript>•+</superscript> scavenging). Also, for reducing capabilities, iron (Fe<superscript>3+</superscript>), copper (Cu<superscript>2+</superscript>), and Fe<superscript>3+</superscript>-2,4,6-tri(2-pyridyl)-S-triazine (TPTZ) reducing abilities were studied. Moreover, kiwifruit oil showed a considerable inhibition effect towards hCA II (IC<subscript>50</subscript>: 505.83 μg/mL), AChE (IC<subscript>50</subscript>: 12.80 μg/mL), and α-amylase (IC<subscript>50</subscript>: 421.02 μg/mL). The results revealed that the use of kiwifruit oil in a pharmaceutical procedure has very important effects due to its antioxidant, anti-Alzheimer, antidiabetic, and antiglaucoma effects. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Life (2075-1729) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.3390/life13091939
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 20
        StartPage: 1939
    Subjects:
      – SubjectFull: KIWIFRUIT
        Type: general
      – SubjectFull: ACTINIDIA
        Type: general
      – SubjectFull: VEGETABLE oils
        Type: general
      – SubjectFull: PETROLEUM
        Type: general
      – SubjectFull: ESSENTIAL oils
        Type: general
      – SubjectFull: ACETYLCHOLINESTERASE
        Type: general
      – SubjectFull: CARYOPHYLLENE
        Type: general
    Titles:
      – TitleFull: Antioxidant, Antiglaucoma, Anticholinergic, and Antidiabetic Effects of Kiwifruit (Actinidia deliciosa) Oil: Metabolite Profile Analysis Using LC-HR/MS, GC/MS and GC-FID.
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            NameFull: Bingol, Zeynebe
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            NameFull: Mutlu, Muzaffer
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            – D: 01
              M: 09
              Text: Sep2023
              Type: published
              Y: 2023
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            – TitleFull: Life (2075-1729)
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