Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury.
| Title: | Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury. |
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| Authors: | Mapuskar, Kranti A., Pulliam, Casey F., Zepeda-Orozco, Diana, Griffin, Benjamin R., Furqan, Muhammad, Spitz, Douglas R., Allen, Bryan G. |
| Source: | Antioxidants; Sep2023, Vol. 12 Issue 9, p1728, 17p |
| Subject Terms: | CISPLATIN, KIDNEY injuries, NUCLEAR factor E2 related factor, OXIDATION-reduction reaction, POST-translational modification, OXIDATIVE stress |
| Abstract: | Cisplatin, a potent chemotherapeutic agent, is marred by severe nephrotoxicity that is governed by mechanisms involving oxidative stress, inflammation, and apoptosis pathways. The transcription factor Nrf2, pivotal in cellular defense against oxidative stress and inflammation, is the master regulator of the antioxidant response, upregulating antioxidants and cytoprotective genes under oxidative stress. This review discusses the mechanisms underlying chemotherapy-induced kidney injury, focusing on the role of Nrf2 in cancer therapy and its redox regulation in cisplatin-induced kidney injury. We also explore Nrf2's signaling pathways, post-translational modifications, and its involvement in autophagy, as well as examine redox-based strategies for modulating Nrf2 in cisplatin-induced kidney injury while considering the limitations and potential off-target effects of Nrf2 modulation. Understanding the redox regulation of Nrf2 in cisplatin-induced kidney injury holds significant promise for developing novel therapeutic interventions. This knowledge could provide valuable insights into potential strategies for mitigating the nephrotoxicity associated with cisplatin, ultimately enhancing the safety and efficacy of cancer treatment. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Mapuskar%2C+Kranti+A%2E%22">Mapuskar, Kranti A.</searchLink><br /><searchLink fieldCode="AR" term="%22Pulliam%2C+Casey+F%2E%22">Pulliam, Casey F.</searchLink><br /><searchLink fieldCode="AR" term="%22Zepeda-Orozco%2C+Diana%22">Zepeda-Orozco, Diana</searchLink><br /><searchLink fieldCode="AR" term="%22Griffin%2C+Benjamin+R%2E%22">Griffin, Benjamin R.</searchLink><br /><searchLink fieldCode="AR" term="%22Furqan%2C+Muhammad%22">Furqan, Muhammad</searchLink><br /><searchLink fieldCode="AR" term="%22Spitz%2C+Douglas+R%2E%22">Spitz, Douglas R.</searchLink><br /><searchLink fieldCode="AR" term="%22Allen%2C+Bryan+G%2E%22">Allen, Bryan G.</searchLink> – Name: TitleSource Label: Source Group: Src Data: Antioxidants; Sep2023, Vol. 12 Issue 9, p1728, 17p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22CISPLATIN%22">CISPLATIN</searchLink><br /><searchLink fieldCode="DE" term="%22KIDNEY+injuries%22">KIDNEY injuries</searchLink><br /><searchLink fieldCode="DE" term="%22NUCLEAR+factor+E2+related+factor%22">NUCLEAR factor E2 related factor</searchLink><br /><searchLink fieldCode="DE" term="%22OXIDATION-reduction+reaction%22">OXIDATION-reduction reaction</searchLink><br /><searchLink fieldCode="DE" term="%22POST-translational+modification%22">POST-translational modification</searchLink><br /><searchLink fieldCode="DE" term="%22OXIDATIVE+stress%22">OXIDATIVE stress</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Cisplatin, a potent chemotherapeutic agent, is marred by severe nephrotoxicity that is governed by mechanisms involving oxidative stress, inflammation, and apoptosis pathways. The transcription factor Nrf2, pivotal in cellular defense against oxidative stress and inflammation, is the master regulator of the antioxidant response, upregulating antioxidants and cytoprotective genes under oxidative stress. This review discusses the mechanisms underlying chemotherapy-induced kidney injury, focusing on the role of Nrf2 in cancer therapy and its redox regulation in cisplatin-induced kidney injury. We also explore Nrf2's signaling pathways, post-translational modifications, and its involvement in autophagy, as well as examine redox-based strategies for modulating Nrf2 in cisplatin-induced kidney injury while considering the limitations and potential off-target effects of Nrf2 modulation. Understanding the redox regulation of Nrf2 in cisplatin-induced kidney injury holds significant promise for developing novel therapeutic interventions. This knowledge could provide valuable insights into potential strategies for mitigating the nephrotoxicity associated with cisplatin, ultimately enhancing the safety and efficacy of cancer treatment. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Antioxidants is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/antiox12091728 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 17 StartPage: 1728 Subjects: – SubjectFull: CISPLATIN Type: general – SubjectFull: KIDNEY injuries Type: general – SubjectFull: NUCLEAR factor E2 related factor Type: general – SubjectFull: OXIDATION-reduction reaction Type: general – SubjectFull: POST-translational modification Type: general – SubjectFull: OXIDATIVE stress Type: general Titles: – TitleFull: Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mapuskar, Kranti A. – PersonEntity: Name: NameFull: Pulliam, Casey F. – PersonEntity: Name: NameFull: Zepeda-Orozco, Diana – PersonEntity: Name: NameFull: Griffin, Benjamin R. – PersonEntity: Name: NameFull: Furqan, Muhammad – PersonEntity: Name: NameFull: Spitz, Douglas R. – PersonEntity: Name: NameFull: Allen, Bryan G. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 20763921 Numbering: – Type: volume Value: 12 – Type: issue Value: 9 Titles: – TitleFull: Antioxidants Type: main |
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