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The localization of centromere protein A is conserved among tissues.

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Title: The localization of centromere protein A is conserved among tissues.
Authors: Cappelletti, Eleonora, Piras, Francesca M., Sola, Lorenzo, Santagostino, Marco, Petersen, Jessica L., Bellone, Rebecca R., Finno, Carrie J., Peng, Sichong, Kalbfleisch, Ted S., Bailey, Ernest, Nergadze, Solomon G., Giulotto, Elena
Source: Communications Biology; 9/21/2023, Vol. 6 Issue 1, p1-8, 8p
Subject Terms: CENTROMERE, SATELLITE DNA, GENE mapping, FETAL tissues, CHROMOSOMES, TISSUES, EQUINE influenza
Abstract: Centromeres are epigenetically specified by the histone H3 variant CENP-A. Although mammalian centromeres are typically associated with satellite DNA, we previously demonstrated that the centromere of horse chromosome 11 (ECA11) is completely devoid of satellite DNA. We also showed that the localization of its CENP-A binding domain is not fixed but slides within an about 500 kb region in different individuals, giving rise to positional alleles. These epialleles are inherited as Mendelian traits but their position can move in one generation. It is still unknown whether centromere sliding occurs during meiosis or during development. Here, we first improve the sequence of the ECA11 centromeric region in the EquCab3.0 assembly. Then, to test whether centromere sliding may occur during development, we map the CENP-A binding domains of ECA11 using ChIP-seq in five tissues of different embryonic origin from the four horses of the equine FAANG (Functional Annotation of ANimal Genomes) consortium. Our results demonstrate that the centromere is localized in the same region in all tissues, suggesting that the position of the centromeric domain is maintained during development. Sequence improvement of the centromeric region of horse chromosome 11 and mapping of the histone H3 variant CENP-A binding domains show that the centromere is localized in the same region in horse tissues from different embryonic origin. [ABSTRACT FROM AUTHOR]
Copyright of Communications Biology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: The localization of centromere protein A is conserved among tissues.
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  Data: <searchLink fieldCode="AR" term="%22Cappelletti%2C+Eleonora%22">Cappelletti, Eleonora</searchLink><br /><searchLink fieldCode="AR" term="%22Piras%2C+Francesca+M%2E%22">Piras, Francesca M.</searchLink><br /><searchLink fieldCode="AR" term="%22Sola%2C+Lorenzo%22">Sola, Lorenzo</searchLink><br /><searchLink fieldCode="AR" term="%22Santagostino%2C+Marco%22">Santagostino, Marco</searchLink><br /><searchLink fieldCode="AR" term="%22Petersen%2C+Jessica+L%2E%22">Petersen, Jessica L.</searchLink><br /><searchLink fieldCode="AR" term="%22Bellone%2C+Rebecca+R%2E%22">Bellone, Rebecca R.</searchLink><br /><searchLink fieldCode="AR" term="%22Finno%2C+Carrie+J%2E%22">Finno, Carrie J.</searchLink><br /><searchLink fieldCode="AR" term="%22Peng%2C+Sichong%22">Peng, Sichong</searchLink><br /><searchLink fieldCode="AR" term="%22Kalbfleisch%2C+Ted+S%2E%22">Kalbfleisch, Ted S.</searchLink><br /><searchLink fieldCode="AR" term="%22Bailey%2C+Ernest%22">Bailey, Ernest</searchLink><br /><searchLink fieldCode="AR" term="%22Nergadze%2C+Solomon+G%2E%22">Nergadze, Solomon G.</searchLink><br /><searchLink fieldCode="AR" term="%22Giulotto%2C+Elena%22">Giulotto, Elena</searchLink>
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  Data: Communications Biology; 9/21/2023, Vol. 6 Issue 1, p1-8, 8p
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  Data: <searchLink fieldCode="DE" term="%22CENTROMERE%22">CENTROMERE</searchLink><br /><searchLink fieldCode="DE" term="%22SATELLITE+DNA%22">SATELLITE DNA</searchLink><br /><searchLink fieldCode="DE" term="%22GENE+mapping%22">GENE mapping</searchLink><br /><searchLink fieldCode="DE" term="%22FETAL+tissues%22">FETAL tissues</searchLink><br /><searchLink fieldCode="DE" term="%22CHROMOSOMES%22">CHROMOSOMES</searchLink><br /><searchLink fieldCode="DE" term="%22TISSUES%22">TISSUES</searchLink><br /><searchLink fieldCode="DE" term="%22EQUINE+influenza%22">EQUINE influenza</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Centromeres are epigenetically specified by the histone H3 variant CENP-A. Although mammalian centromeres are typically associated with satellite DNA, we previously demonstrated that the centromere of horse chromosome 11 (ECA11) is completely devoid of satellite DNA. We also showed that the localization of its CENP-A binding domain is not fixed but slides within an about 500 kb region in different individuals, giving rise to positional alleles. These epialleles are inherited as Mendelian traits but their position can move in one generation. It is still unknown whether centromere sliding occurs during meiosis or during development. Here, we first improve the sequence of the ECA11 centromeric region in the EquCab3.0 assembly. Then, to test whether centromere sliding may occur during development, we map the CENP-A binding domains of ECA11 using ChIP-seq in five tissues of different embryonic origin from the four horses of the equine FAANG (Functional Annotation of ANimal Genomes) consortium. Our results demonstrate that the centromere is localized in the same region in all tissues, suggesting that the position of the centromeric domain is maintained during development. Sequence improvement of the centromeric region of horse chromosome 11 and mapping of the histone H3 variant CENP-A binding domains show that the centromere is localized in the same region in horse tissues from different embryonic origin. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Communications Biology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1038/s42003-023-05335-7
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        Text: English
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