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Phenotypic variation in milk fatty acid composition and its association with stearoyl‐CoA desaturase 1 (SCD1) gene polymorphisms in Gir cows.

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Title: Phenotypic variation in milk fatty acid composition and its association with stearoyl‐CoA desaturase 1 (SCD1) gene polymorphisms in Gir cows.
Authors: Matosinho, Carolina Guimarães Ramos, Fonseca, Pablo Augusto de Souza, Peixoto, Maria Gabriela Campolina Diniz, Rosse, Izinara Cruz, Lopes, Fernando César Ferraz, Zózimo, Thalia, Filho, Aníbal Eugênio Vercesi, Bruneli, Frank Ângelo Tomita, Carvalho, Maria Raquel Santos, Gama, Marco Antonio Sundfeld
Source: Journal of Animal Breeding & Genetics; Sep2023, Vol. 140 Issue 5, p532-548, 17p
Subject Terms: PHENOTYPIC plasticity, GENETIC polymorphisms, COWS, FATTY acids, COMPOSITION of milk, CATTLE genetics
Geographic Terms: BRAZIL
Abstract: Individual variation in milk fatty acid (FA) composition has been partially attributed to stearoyl‐CoA desaturase 1 (SCD1) gene polymorphisms in taurine breeds, but much less is known for Zebu breeds. This study investigated the phenotypic variation in milk FA composition, and the influence of SCD1 variants on this trait and on milk fat desaturase indices (DI) in Gir cows. The functional impact of SCD1 variants was predicted using bioinformatics tools. Milk and blood samples were collected from 312 cows distributed in 10 herds from five states of Brazil. SCD1 variants were identified through target sequencing, and milk FA composition was determined by gas chromatography. Phenotypic variation in milk FA composition fell within the range reported for taurine breeds, with SCD18 index showing the lowest variation among the DI. Fourteen SCD1 variants were identified, six of which not previously described. Regarding the A293V polymorphism, all cows were homozygous for the C allele (coding for alanine), whereas all genotypes were detected for the second SNP affecting the 293 codon (G > A), with compelling evidence for functional effects. Significant associations (based on raw p‐values) were found between this SNP and C12:0, cis‐9, trans‐11 CLA and short‐chain FA, and between another SNP (rs523411937) and C15:0 and odd‐chain linear FA. A new SNP on Chr26:21277069 was associated with trans‐11 C18:1, cis‐9, trans‐11 CLA, C18:3 n‐3 and n‐3 FA. These findings indicate that SCD1 polymorphisms also contributes to the phenotypic variation in milk FA composition of Gir cows, with potential use in their breeding programmes. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Animal Breeding & Genetics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Phenotypic variation in milk fatty acid composition and its association with stearoyl‐CoA desaturase 1 (SCD1) gene polymorphisms in Gir cows.
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  Data: Journal of Animal Breeding & Genetics; Sep2023, Vol. 140 Issue 5, p532-548, 17p
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  Data: <searchLink fieldCode="DE" term="%22PHENOTYPIC+plasticity%22">PHENOTYPIC plasticity</searchLink><br /><searchLink fieldCode="DE" term="%22GENETIC+polymorphisms%22">GENETIC polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22COWS%22">COWS</searchLink><br /><searchLink fieldCode="DE" term="%22FATTY+acids%22">FATTY acids</searchLink><br /><searchLink fieldCode="DE" term="%22COMPOSITION+of+milk%22">COMPOSITION of milk</searchLink><br /><searchLink fieldCode="DE" term="%22CATTLE+genetics%22">CATTLE genetics</searchLink>
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Individual variation in milk fatty acid (FA) composition has been partially attributed to stearoyl‐CoA desaturase 1 (SCD1) gene polymorphisms in taurine breeds, but much less is known for Zebu breeds. This study investigated the phenotypic variation in milk FA composition, and the influence of SCD1 variants on this trait and on milk fat desaturase indices (DI) in Gir cows. The functional impact of SCD1 variants was predicted using bioinformatics tools. Milk and blood samples were collected from 312 cows distributed in 10 herds from five states of Brazil. SCD1 variants were identified through target sequencing, and milk FA composition was determined by gas chromatography. Phenotypic variation in milk FA composition fell within the range reported for taurine breeds, with SCD18 index showing the lowest variation among the DI. Fourteen SCD1 variants were identified, six of which not previously described. Regarding the A293V polymorphism, all cows were homozygous for the C allele (coding for alanine), whereas all genotypes were detected for the second SNP affecting the 293 codon (G > A), with compelling evidence for functional effects. Significant associations (based on raw p‐values) were found between this SNP and C12:0, cis‐9, trans‐11 CLA and short‐chain FA, and between another SNP (rs523411937) and C15:0 and odd‐chain linear FA. A new SNP on Chr26:21277069 was associated with trans‐11 C18:1, cis‐9, trans‐11 CLA, C18:3 n‐3 and n‐3 FA. These findings indicate that SCD1 polymorphisms also contributes to the phenotypic variation in milk FA composition of Gir cows, with potential use in their breeding programmes. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Animal Breeding & Genetics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1111/jbg.12777
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      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 17
        StartPage: 532
    Subjects:
      – SubjectFull: BRAZIL
        Type: general
      – SubjectFull: PHENOTYPIC plasticity
        Type: general
      – SubjectFull: GENETIC polymorphisms
        Type: general
      – SubjectFull: COWS
        Type: general
      – SubjectFull: FATTY acids
        Type: general
      – SubjectFull: COMPOSITION of milk
        Type: general
      – SubjectFull: CATTLE genetics
        Type: general
    Titles:
      – TitleFull: Phenotypic variation in milk fatty acid composition and its association with stearoyl‐CoA desaturase 1 (SCD1) gene polymorphisms in Gir cows.
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            NameFull: Matosinho, Carolina Guimarães Ramos
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            – D: 01
              M: 09
              Text: Sep2023
              Type: published
              Y: 2023
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