Academic Journal
View in EDS

Assessment of Immunity against Hepatitis B Virus among Children Aged 2-17 Years in Nnewi, Anambra State, South-East Nigeria: A Pilot Study.

Bibliographic Details
Title: Assessment of Immunity against Hepatitis B Virus among Children Aged 2-17 Years in Nnewi, Anambra State, South-East Nigeria: A Pilot Study.
Authors: Chukwurah, Shirley Nneka, Jisieike-Onuigbo, Nonyelum Nnenna, Onubogu, Chinyere Ukamaka, Kalu, Stephen Okorafor, Ufoaroh, Chinyelu Uchenna, Onah, Stanley Kenechukwu, Eleje, George Uchenna, Mbanuzuru, Victor Ahoma, Ezejiofor, Ogochukwu Ifeanyi, Ezeude, Chidiebele Malachy, Okpala, Chibuzor Ifeanyi, Onah, Christian Ejike, Nweje, Ifeyinwa Sussan, Ekwebene, Onyeka Chukwudalu, Eze, Kenneth Chukwudi, Ugochukwu, Ebele Francesca, Ibe, Christian Chibuzo
Source: Journal of Health & Medical Sciences; Jun2023, Vol. 6 Issue 2, p63-71, 9p
Subject Terms: HEPATITIS B virus, HEPATITIS associated antigen, DISEASE prevalence, PILOT projects, VACCINATION of children
Geographic Terms: NIGERIA
Abstract: Background: Nigeria is one of the hyper-endemic countries for hepatitis B with national prevalence rate of 11%. No study has been done in Nigeria to the best of authors' knowledge to assess the level of immunity among children vaccinated against HBV. Objective: To assess prevalence of Hepatitis B surface antigen, determine the presence of antibodies to hepatitis B surface antigen (anti-HBs) and determine the titre levels of anti-HBs among those who have anti-HBs. Design: This was a pilot and a cross-sectional study. Methods: Consecutive children aged between 2 and 17 years seen at the outpatient clinic of NAUTH, Nnewi, Nigeria were recruited. Questionnaire was interviewer-administered. Venous blood was collected from each participant, analyzed for HBV serological markers and anti-HBs titre. Results: A total of sixty children were recruited. There was equal male and female distribution. 36.7% were aged 10-14 years. One child did not receive HBV vaccine. There was no incidental finding of HbsAg positivity. 15% of respondents had their immunity assessed after completing vaccination. There was presence of antibodies to HBsAg in19 children, and the anti-HBs titre was protective in 78.9% of those who had antibodies. Conclusion: After 18 years of introduction of the HBV vaccine into the NPI and routine infant immunization against hepatitis B virus in Nigeria, this pilot study has shown immunity against hepatitis B is not usually assessed after immunization and a significant proportion of children who were adequately immunized are not adequately protected against HBV. A large-scale study would be desirable for confirmation. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Health & Medical Sciences is the property of Asian Institute of Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edb&genre=article&issn=26227258&ISBN=&volume=6&issue=2&date=20230601&spage=63&pages=63-71&title=Journal of Health & Medical Sciences&atitle=Assessment%20of%20Immunity%20against%20Hepatitis%20B%20Virus%20among%20Children%20Aged%202-17%20Years%20in%20Nnewi%2C%20Anambra%20State%2C%20South-East%20Nigeria%3A%20A%20Pilot%20Study.&aulast=Chukwurah%2C%20Shirley%20Nneka&id=DOI:10.31014/aior.1994.06.02.269
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: edb
DbLabel: Complementary Index
An: 164795441
RelevancyScore: 973
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 973.296813964844
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Assessment of Immunity against Hepatitis B Virus among Children Aged 2-17 Years in Nnewi, Anambra State, South-East Nigeria: A Pilot Study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Chukwurah%2C+Shirley+Nneka%22">Chukwurah, Shirley Nneka</searchLink><br /><searchLink fieldCode="AR" term="%22Jisieike-Onuigbo%2C+Nonyelum+Nnenna%22">Jisieike-Onuigbo, Nonyelum Nnenna</searchLink><br /><searchLink fieldCode="AR" term="%22Onubogu%2C+Chinyere+Ukamaka%22">Onubogu, Chinyere Ukamaka</searchLink><br /><searchLink fieldCode="AR" term="%22Kalu%2C+Stephen+Okorafor%22">Kalu, Stephen Okorafor</searchLink><br /><searchLink fieldCode="AR" term="%22Ufoaroh%2C+Chinyelu+Uchenna%22">Ufoaroh, Chinyelu Uchenna</searchLink><br /><searchLink fieldCode="AR" term="%22Onah%2C+Stanley+Kenechukwu%22">Onah, Stanley Kenechukwu</searchLink><br /><searchLink fieldCode="AR" term="%22Eleje%2C+George+Uchenna%22">Eleje, George Uchenna</searchLink><br /><searchLink fieldCode="AR" term="%22Mbanuzuru%2C+Victor+Ahoma%22">Mbanuzuru, Victor Ahoma</searchLink><br /><searchLink fieldCode="AR" term="%22Ezejiofor%2C+Ogochukwu+Ifeanyi%22">Ezejiofor, Ogochukwu Ifeanyi</searchLink><br /><searchLink fieldCode="AR" term="%22Ezeude%2C+Chidiebele+Malachy%22">Ezeude, Chidiebele Malachy</searchLink><br /><searchLink fieldCode="AR" term="%22Okpala%2C+Chibuzor+Ifeanyi%22">Okpala, Chibuzor Ifeanyi</searchLink><br /><searchLink fieldCode="AR" term="%22Onah%2C+Christian+Ejike%22">Onah, Christian Ejike</searchLink><br /><searchLink fieldCode="AR" term="%22Nweje%2C+Ifeyinwa+Sussan%22">Nweje, Ifeyinwa Sussan</searchLink><br /><searchLink fieldCode="AR" term="%22Ekwebene%2C+Onyeka+Chukwudalu%22">Ekwebene, Onyeka Chukwudalu</searchLink><br /><searchLink fieldCode="AR" term="%22Eze%2C+Kenneth+Chukwudi%22">Eze, Kenneth Chukwudi</searchLink><br /><searchLink fieldCode="AR" term="%22Ugochukwu%2C+Ebele+Francesca%22">Ugochukwu, Ebele Francesca</searchLink><br /><searchLink fieldCode="AR" term="%22Ibe%2C+Christian+Chibuzo%22">Ibe, Christian Chibuzo</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Journal of Health & Medical Sciences; Jun2023, Vol. 6 Issue 2, p63-71, 9p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22HEPATITIS+B+virus%22">HEPATITIS B virus</searchLink><br /><searchLink fieldCode="DE" term="%22HEPATITIS+associated+antigen%22">HEPATITIS associated antigen</searchLink><br /><searchLink fieldCode="DE" term="%22DISEASE+prevalence%22">DISEASE prevalence</searchLink><br /><searchLink fieldCode="DE" term="%22PILOT+projects%22">PILOT projects</searchLink><br /><searchLink fieldCode="DE" term="%22VACCINATION+of+children%22">VACCINATION of children</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22NIGERIA%22">NIGERIA</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Nigeria is one of the hyper-endemic countries for hepatitis B with national prevalence rate of 11%. No study has been done in Nigeria to the best of authors' knowledge to assess the level of immunity among children vaccinated against HBV. Objective: To assess prevalence of Hepatitis B surface antigen, determine the presence of antibodies to hepatitis B surface antigen (anti-HBs) and determine the titre levels of anti-HBs among those who have anti-HBs. Design: This was a pilot and a cross-sectional study. Methods: Consecutive children aged between 2 and 17 years seen at the outpatient clinic of NAUTH, Nnewi, Nigeria were recruited. Questionnaire was interviewer-administered. Venous blood was collected from each participant, analyzed for HBV serological markers and anti-HBs titre. Results: A total of sixty children were recruited. There was equal male and female distribution. 36.7% were aged 10-14 years. One child did not receive HBV vaccine. There was no incidental finding of HbsAg positivity. 15% of respondents had their immunity assessed after completing vaccination. There was presence of antibodies to HBsAg in19 children, and the anti-HBs titre was protective in 78.9% of those who had antibodies. Conclusion: After 18 years of introduction of the HBV vaccine into the NPI and routine infant immunization against hepatitis B virus in Nigeria, this pilot study has shown immunity against hepatitis B is not usually assessed after immunization and a significant proportion of children who were adequately immunized are not adequately protected against HBV. A large-scale study would be desirable for confirmation. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Health & Medical Sciences is the property of Asian Institute of Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=164795441
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.31014/aior.1994.06.02.269
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 63
    Subjects:
      – SubjectFull: NIGERIA
        Type: general
      – SubjectFull: HEPATITIS B virus
        Type: general
      – SubjectFull: HEPATITIS associated antigen
        Type: general
      – SubjectFull: DISEASE prevalence
        Type: general
      – SubjectFull: PILOT projects
        Type: general
      – SubjectFull: VACCINATION of children
        Type: general
    Titles:
      – TitleFull: Assessment of Immunity against Hepatitis B Virus among Children Aged 2-17 Years in Nnewi, Anambra State, South-East Nigeria: A Pilot Study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Chukwurah, Shirley Nneka
      – PersonEntity:
          Name:
            NameFull: Jisieike-Onuigbo, Nonyelum Nnenna
      – PersonEntity:
          Name:
            NameFull: Onubogu, Chinyere Ukamaka
      – PersonEntity:
          Name:
            NameFull: Kalu, Stephen Okorafor
      – PersonEntity:
          Name:
            NameFull: Ufoaroh, Chinyelu Uchenna
      – PersonEntity:
          Name:
            NameFull: Onah, Stanley Kenechukwu
      – PersonEntity:
          Name:
            NameFull: Eleje, George Uchenna
      – PersonEntity:
          Name:
            NameFull: Mbanuzuru, Victor Ahoma
      – PersonEntity:
          Name:
            NameFull: Ezejiofor, Ogochukwu Ifeanyi
      – PersonEntity:
          Name:
            NameFull: Ezeude, Chidiebele Malachy
      – PersonEntity:
          Name:
            NameFull: Okpala, Chibuzor Ifeanyi
      – PersonEntity:
          Name:
            NameFull: Onah, Christian Ejike
      – PersonEntity:
          Name:
            NameFull: Nweje, Ifeyinwa Sussan
      – PersonEntity:
          Name:
            NameFull: Ekwebene, Onyeka Chukwudalu
      – PersonEntity:
          Name:
            NameFull: Eze, Kenneth Chukwudi
      – PersonEntity:
          Name:
            NameFull: Ugochukwu, Ebele Francesca
      – PersonEntity:
          Name:
            NameFull: Ibe, Christian Chibuzo
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2023
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 26227258
          Numbering:
            – Type: volume
              Value: 6
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Journal of Health & Medical Sciences
              Type: main
ResultId 1