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Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice.

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Title: Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice.
Authors: Aboouf, Mostafa A., Armbruster, Julia, Guscetti, Franco, Thiersch, Markus, Boss, Andreas, Gödecke, Axel, Winning, Sandra, Padberg, Claudia, Fandrey, Joachim, Kristiansen, Glen, Bicker, Anne, Hankeln, Thomas, Gassmann, Max, Gorr, Thomas A.
Source: Scientific Reports; 5/9/2023, Vol. 13 Issue 1, p1-17, 17p
Subject Terms: MICE, MYOGLOBIN, LABORATORY mice, HYPOXEMIA, BREAST cancer prognosis, TUMOR growth, CANCER invasiveness
Abstract: Myoglobin (MB) is expressed in different cancer types and may act as a tumor suppressor in breast cancer. The mechanisms by which basal MB expression level impacts murine mammary tumorigenesis are unclear. We investigated how MB expression in breast cancer influences proliferation, metastasis, tumor hypoxia, and chemotherapy treatment in vivo. We crossed PyMT and WapCreTrp53flox mammary cancer mouse models that differed in tumor grade/type and onset of mammary carcinoma with MB knockout mice. The loss of MB in WapCre;Trp53flox mice did not affect tumor development and progression. On the other hand, loss of MB decreased tumor growth and increased tissue hypoxia as well as the number of lung metastases in PyMT mice. Furthermore, Doxorubicin therapy prevented the stronger metastatic propensity of MB-deficient tumors in PyMT mice. This suggests that, although MB expression predicts improved prognosis in breast cancer patients, MB-deficient tumors may still respond well to first-line therapies. We propose that determining the expression level of MB in malignant breast cancer biopsies will improve tumor stratification, outcome prediction, and personalized therapy in cancer patients. [ABSTRACT FROM AUTHOR]
Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice.
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  Data: Scientific Reports; 5/9/2023, Vol. 13 Issue 1, p1-17, 17p
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  Data: <searchLink fieldCode="DE" term="%22MICE%22">MICE</searchLink><br /><searchLink fieldCode="DE" term="%22MYOGLOBIN%22">MYOGLOBIN</searchLink><br /><searchLink fieldCode="DE" term="%22LABORATORY+mice%22">LABORATORY mice</searchLink><br /><searchLink fieldCode="DE" term="%22HYPOXEMIA%22">HYPOXEMIA</searchLink><br /><searchLink fieldCode="DE" term="%22BREAST+cancer+prognosis%22">BREAST cancer prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22TUMOR+growth%22">TUMOR growth</searchLink><br /><searchLink fieldCode="DE" term="%22CANCER+invasiveness%22">CANCER invasiveness</searchLink>
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  Data: Myoglobin (MB) is expressed in different cancer types and may act as a tumor suppressor in breast cancer. The mechanisms by which basal MB expression level impacts murine mammary tumorigenesis are unclear. We investigated how MB expression in breast cancer influences proliferation, metastasis, tumor hypoxia, and chemotherapy treatment in vivo. We crossed PyMT and WapCreTrp53<superscript>flox</superscript> mammary cancer mouse models that differed in tumor grade/type and onset of mammary carcinoma with MB knockout mice. The loss of MB in WapCre;Trp53<superscript>flox</superscript> mice did not affect tumor development and progression. On the other hand, loss of MB decreased tumor growth and increased tissue hypoxia as well as the number of lung metastases in PyMT mice. Furthermore, Doxorubicin therapy prevented the stronger metastatic propensity of MB-deficient tumors in PyMT mice. This suggests that, although MB expression predicts improved prognosis in breast cancer patients, MB-deficient tumors may still respond well to first-line therapies. We propose that determining the expression level of MB in malignant breast cancer biopsies will improve tumor stratification, outcome prediction, and personalized therapy in cancer patients. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1038/s41598-023-34614-w
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        Text: English
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        Type: general
      – SubjectFull: MYOGLOBIN
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              Text: 5/9/2023
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