The Therapeutic Potential of Non-Invasive and Invasive Cerebellar Stimulation Techniques in Hereditary Ataxias.
| Title: | The Therapeutic Potential of Non-Invasive and Invasive Cerebellar Stimulation Techniques in Hereditary Ataxias. |
|---|---|
| Authors: | Benussi, Alberto, Batsikadze, Giorgi, França, Carina, Cury, Rubens G., Maas, Roderick P. P. W. M. |
| Source: | Cells (2073-4409); Apr2023, Vol. 12 Issue 8, p1193, 25p |
| Subject Terms: | BRAIN stimulation, TRANSCRANIAL direct current stimulation, TRANSCRANIAL magnetic stimulation, DENTATE nucleus, DEEP brain stimulation, RANDOMIZED controlled trials |
| Abstract: | The degenerative ataxias comprise a heterogeneous group of inherited and acquired disorders that are characterized by a progressive cerebellar syndrome, frequently in combination with one or more extracerebellar signs. Specific disease-modifying interventions are currently not available for many of these rare conditions, which underscores the necessity of finding effective symptomatic therapies. During the past five to ten years, an increasing number of randomized controlled trials have been conducted examining the potential of different non-invasive brain stimulation techniques to induce symptomatic improvement. In addition, a few smaller studies have explored deep brain stimulation (DBS) of the dentate nucleus as an invasive means to directly modulate cerebellar output, thereby aiming to alleviate ataxia severity. In this paper, we comprehensively review the clinical and neurophysiological effects of transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and dentate nucleus DBS in patients with hereditary ataxias, as well as the presumed underlying mechanisms at the cellular and network level and perspectives for future research. [ABSTRACT FROM AUTHOR] |
| Copyright of Cells (2073-4409) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Complementary Index |
| Full text is not displayed to guests. | Login for full access. |
| FullText | Links: – Type: pdflink Text: Availability: 1 CustomLinks: – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edb&genre=article&issn=20734409&ISBN=&volume=12&issue=8&date=20230415&spage=1193&pages=1193-1217&title=Cells (2073-4409)&atitle=The%20Therapeutic%20Potential%20of%20Non-Invasive%20and%20Invasive%20Cerebellar%20Stimulation%20Techniques%20in%20Hereditary%20Ataxias.&aulast=Benussi%2C%20Alberto&id=DOI:10.3390/cells12081193 Name: Full Text Finder (for New FTF UI) (s8985755) Category: fullText Text: Find It @ SCU Libraries MouseOverText: Find It @ SCU Libraries |
|---|---|
| Header | DbId: edb DbLabel: Complementary Index An: 163378045 RelevancyScore: 965 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 965.41748046875 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: The Therapeutic Potential of Non-Invasive and Invasive Cerebellar Stimulation Techniques in Hereditary Ataxias. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Benussi%2C+Alberto%22">Benussi, Alberto</searchLink><br /><searchLink fieldCode="AR" term="%22Batsikadze%2C+Giorgi%22">Batsikadze, Giorgi</searchLink><br /><searchLink fieldCode="AR" term="%22França%2C+Carina%22">França, Carina</searchLink><br /><searchLink fieldCode="AR" term="%22Cury%2C+Rubens+G%2E%22">Cury, Rubens G.</searchLink><br /><searchLink fieldCode="AR" term="%22Maas%2C+Roderick+P%2E+P%2E+W%2E+M%2E%22">Maas, Roderick P. P. W. M.</searchLink> – Name: TitleSource Label: Source Group: Src Data: Cells (2073-4409); Apr2023, Vol. 12 Issue 8, p1193, 25p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22BRAIN+stimulation%22">BRAIN stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22TRANSCRANIAL+direct+current+stimulation%22">TRANSCRANIAL direct current stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22TRANSCRANIAL+magnetic+stimulation%22">TRANSCRANIAL magnetic stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22DENTATE+nucleus%22">DENTATE nucleus</searchLink><br /><searchLink fieldCode="DE" term="%22DEEP+brain+stimulation%22">DEEP brain stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22RANDOMIZED+controlled+trials%22">RANDOMIZED controlled trials</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The degenerative ataxias comprise a heterogeneous group of inherited and acquired disorders that are characterized by a progressive cerebellar syndrome, frequently in combination with one or more extracerebellar signs. Specific disease-modifying interventions are currently not available for many of these rare conditions, which underscores the necessity of finding effective symptomatic therapies. During the past five to ten years, an increasing number of randomized controlled trials have been conducted examining the potential of different non-invasive brain stimulation techniques to induce symptomatic improvement. In addition, a few smaller studies have explored deep brain stimulation (DBS) of the dentate nucleus as an invasive means to directly modulate cerebellar output, thereby aiming to alleviate ataxia severity. In this paper, we comprehensively review the clinical and neurophysiological effects of transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and dentate nucleus DBS in patients with hereditary ataxias, as well as the presumed underlying mechanisms at the cellular and network level and perspectives for future research. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Cells (2073-4409) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=163378045 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/cells12081193 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 25 StartPage: 1193 Subjects: – SubjectFull: BRAIN stimulation Type: general – SubjectFull: TRANSCRANIAL direct current stimulation Type: general – SubjectFull: TRANSCRANIAL magnetic stimulation Type: general – SubjectFull: DENTATE nucleus Type: general – SubjectFull: DEEP brain stimulation Type: general – SubjectFull: RANDOMIZED controlled trials Type: general Titles: – TitleFull: The Therapeutic Potential of Non-Invasive and Invasive Cerebellar Stimulation Techniques in Hereditary Ataxias. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Benussi, Alberto – PersonEntity: Name: NameFull: Batsikadze, Giorgi – PersonEntity: Name: NameFull: França, Carina – PersonEntity: Name: NameFull: Cury, Rubens G. – PersonEntity: Name: NameFull: Maas, Roderick P. P. W. M. IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 04 Text: Apr2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 20734409 Numbering: – Type: volume Value: 12 – Type: issue Value: 8 Titles: – TitleFull: Cells (2073-4409) Type: main |
| ResultId | 1 |