SARS-CoV-2 Spike Protein and Neutralizing Anti-Spike Protein Antibodies Modulate Blood Platelet Function.
| Title: | SARS-CoV-2 Spike Protein and Neutralizing Anti-Spike Protein Antibodies Modulate Blood Platelet Function. |
|---|---|
| Authors: | Luzak, Boguslawa, Rozalski, Marcin, Przygodzki, Tomasz, Boncler, Magdalena, Wojkowska, Dagmara, Kosmalski, Marcin, Watala, Cezary |
| Source: | International Journal of Molecular Sciences; Mar2023, Vol. 24 Issue 6, p5312, 22p |
| Subject Terms: | BLOOD platelet aggregation, BLOOD platelets, THROMBOPOIETIN receptors, BLOOD platelet activation, SARS-CoV-2, PLATELET count, COVID-19 |
| Abstract: | Several studies report elevated blood platelet activation and altered platelet count in COVID-19 patients, but the role of the SARS-CoV-2 spike protein in this process remains intriguing. Additionally, there is no data that anti-SARS-CoV-2 neutralizing antibodies (nAb) may attenuate spike protein activity toward blood platelets. Our results indicate that under in vitro conditions, the spike protein increased the collagen-stimulated aggregation of isolated platelets and induced the binding of vWF to platelets in ristocetin-treated blood. The spike protein also significantly reduced collagen- or ADP-induced aggregation or decreased GPIIbIIIa (fibrinogen receptor) activation in whole blood, depending on the presence of the anti-spike protein nAb. Our findings suggest that studies on platelet activation/reactivity in COVID-19 patients or in donors vaccinated with anti-SARS-CoV-2 and/or previously-infected COVID-19 should be supported by measurements of spike protein and IgG anti-spike protein antibody concentrations in blood. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: SARS-CoV-2 Spike Protein and Neutralizing Anti-Spike Protein Antibodies Modulate Blood Platelet Function. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Luzak%2C+Boguslawa%22">Luzak, Boguslawa</searchLink><br /><searchLink fieldCode="AR" term="%22Rozalski%2C+Marcin%22">Rozalski, Marcin</searchLink><br /><searchLink fieldCode="AR" term="%22Przygodzki%2C+Tomasz%22">Przygodzki, Tomasz</searchLink><br /><searchLink fieldCode="AR" term="%22Boncler%2C+Magdalena%22">Boncler, Magdalena</searchLink><br /><searchLink fieldCode="AR" term="%22Wojkowska%2C+Dagmara%22">Wojkowska, Dagmara</searchLink><br /><searchLink fieldCode="AR" term="%22Kosmalski%2C+Marcin%22">Kosmalski, Marcin</searchLink><br /><searchLink fieldCode="AR" term="%22Watala%2C+Cezary%22">Watala, Cezary</searchLink> – Name: TitleSource Label: Source Group: Src Data: International Journal of Molecular Sciences; Mar2023, Vol. 24 Issue 6, p5312, 22p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22BLOOD+platelet+aggregation%22">BLOOD platelet aggregation</searchLink><br /><searchLink fieldCode="DE" term="%22BLOOD+platelets%22">BLOOD platelets</searchLink><br /><searchLink fieldCode="DE" term="%22THROMBOPOIETIN+receptors%22">THROMBOPOIETIN receptors</searchLink><br /><searchLink fieldCode="DE" term="%22BLOOD+platelet+activation%22">BLOOD platelet activation</searchLink><br /><searchLink fieldCode="DE" term="%22SARS-CoV-2%22">SARS-CoV-2</searchLink><br /><searchLink fieldCode="DE" term="%22PLATELET+count%22">PLATELET count</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19%22">COVID-19</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Several studies report elevated blood platelet activation and altered platelet count in COVID-19 patients, but the role of the SARS-CoV-2 spike protein in this process remains intriguing. Additionally, there is no data that anti-SARS-CoV-2 neutralizing antibodies (nAb) may attenuate spike protein activity toward blood platelets. Our results indicate that under in vitro conditions, the spike protein increased the collagen-stimulated aggregation of isolated platelets and induced the binding of vWF to platelets in ristocetin-treated blood. The spike protein also significantly reduced collagen- or ADP-induced aggregation or decreased GPIIbIIIa (fibrinogen receptor) activation in whole blood, depending on the presence of the anti-spike protein nAb. Our findings suggest that studies on platelet activation/reactivity in COVID-19 patients or in donors vaccinated with anti-SARS-CoV-2 and/or previously-infected COVID-19 should be supported by measurements of spike protein and IgG anti-spike protein antibody concentrations in blood. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/ijms24065312 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 22 StartPage: 5312 Subjects: – SubjectFull: BLOOD platelet aggregation Type: general – SubjectFull: BLOOD platelets Type: general – SubjectFull: THROMBOPOIETIN receptors Type: general – SubjectFull: BLOOD platelet activation Type: general – SubjectFull: SARS-CoV-2 Type: general – SubjectFull: PLATELET count Type: general – SubjectFull: COVID-19 Type: general Titles: – TitleFull: SARS-CoV-2 Spike Protein and Neutralizing Anti-Spike Protein Antibodies Modulate Blood Platelet Function. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Luzak, Boguslawa – PersonEntity: Name: NameFull: Rozalski, Marcin – PersonEntity: Name: NameFull: Przygodzki, Tomasz – PersonEntity: Name: NameFull: Boncler, Magdalena – PersonEntity: Name: NameFull: Wojkowska, Dagmara – PersonEntity: Name: NameFull: Kosmalski, Marcin – PersonEntity: Name: NameFull: Watala, Cezary IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 03 Text: Mar2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 16616596 Numbering: – Type: volume Value: 24 – Type: issue Value: 6 Titles: – TitleFull: International Journal of Molecular Sciences Type: main |
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