Brain Atrophy Is Substantially Accelerated in Neurological Wilson's Disease: A Longitudinal Study.
| Title: | Brain Atrophy Is Substantially Accelerated in Neurological Wilson's Disease: A Longitudinal Study. |
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| Authors: | Smolinski, Lukasz, Ziemssen, Tjalf, Akgun, Katja, Antos, Agnieszka, Skowrońska, Marta, Kurkowska‐Jastrzębska, Iwona, Członkowska, Anna, Litwin, Tomasz |
| Source: | Movement Disorders; Dec2022, Vol. 37 Issue 12, p2446-2451, 6p |
| Abstract: | Background: Although brain atrophy is common in neurological Wilson's disease, longitudinal studies are lacking. Objective: The objective of this study was to measure longitudinal brain atrophy rate and to relate it to the change in neurological impairment in Wilson's disease. Methods: We included patients with brain imaging done at diagnosis and at least 12 months later. The atrophy rate was measured as percentage change in ventricular volume, whereas the change in neurological impairment was scored on the Unified Wilson's Disease Rating Scale. Results: Of 57 patients, 36 had neurological presentation, 17 had hepatic presentation, and 4 were presymptomatic. The annualized atrophy rate was significantly greater in patients with the neurological presentation than in other patients (P = 0.001). In the neurological presentation, the atrophy rate correlated with the change in impairment (rho = 0.39, P = 0.018) and was significantly greater in those with worsening after diagnosis than in those without worsening (P < 0.001). Conclusions: Brain atrophy rate appears as a promising marker of neurodegeneration in Wilson's disease. © 2022 International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Brain Atrophy Is Substantially Accelerated in Neurological Wilson's Disease: A Longitudinal Study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Smolinski%2C+Lukasz%22">Smolinski, Lukasz</searchLink><br /><searchLink fieldCode="AR" term="%22Ziemssen%2C+Tjalf%22">Ziemssen, Tjalf</searchLink><br /><searchLink fieldCode="AR" term="%22Akgun%2C+Katja%22">Akgun, Katja</searchLink><br /><searchLink fieldCode="AR" term="%22Antos%2C+Agnieszka%22">Antos, Agnieszka</searchLink><br /><searchLink fieldCode="AR" term="%22Skowrońska%2C+Marta%22">Skowrońska, Marta</searchLink><br /><searchLink fieldCode="AR" term="%22Kurkowska‐Jastrzębska%2C+Iwona%22">Kurkowska‐Jastrzębska, Iwona</searchLink><br /><searchLink fieldCode="AR" term="%22Członkowska%2C+Anna%22">Członkowska, Anna</searchLink><br /><searchLink fieldCode="AR" term="%22Litwin%2C+Tomasz%22">Litwin, Tomasz</searchLink> – Name: TitleSource Label: Source Group: Src Data: Movement Disorders; Dec2022, Vol. 37 Issue 12, p2446-2451, 6p – Name: Abstract Label: Abstract Group: Ab Data: Background: Although brain atrophy is common in neurological Wilson's disease, longitudinal studies are lacking. Objective: The objective of this study was to measure longitudinal brain atrophy rate and to relate it to the change in neurological impairment in Wilson's disease. Methods: We included patients with brain imaging done at diagnosis and at least 12 months later. The atrophy rate was measured as percentage change in ventricular volume, whereas the change in neurological impairment was scored on the Unified Wilson's Disease Rating Scale. Results: Of 57 patients, 36 had neurological presentation, 17 had hepatic presentation, and 4 were presymptomatic. The annualized atrophy rate was significantly greater in patients with the neurological presentation than in other patients (P = 0.001). In the neurological presentation, the atrophy rate correlated with the change in impairment (rho = 0.39, P = 0.018) and was significantly greater in those with worsening after diagnosis than in those without worsening (P < 0.001). Conclusions: Brain atrophy rate appears as a promising marker of neurodegeneration in Wilson's disease. © 2022 International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Movement Disorders is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mds.29229 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 2446 Titles: – TitleFull: Brain Atrophy Is Substantially Accelerated in Neurological Wilson's Disease: A Longitudinal Study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Smolinski, Lukasz – PersonEntity: Name: NameFull: Ziemssen, Tjalf – PersonEntity: Name: NameFull: Akgun, Katja – PersonEntity: Name: NameFull: Antos, Agnieszka – PersonEntity: Name: NameFull: Skowrońska, Marta – PersonEntity: Name: NameFull: Kurkowska‐Jastrzębska, Iwona – PersonEntity: Name: NameFull: Członkowska, Anna – PersonEntity: Name: NameFull: Litwin, Tomasz IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 08853185 Numbering: – Type: volume Value: 37 – Type: issue Value: 12 Titles: – TitleFull: Movement Disorders Type: main |
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