Evolution of tricuspid regurgitation after transcatheter edge‐to‐edge mitral valve repair for secondary mitral regurgitation and its impact on mortality.
| Title: | Evolution of tricuspid regurgitation after transcatheter edge‐to‐edge mitral valve repair for secondary mitral regurgitation and its impact on mortality. |
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| Authors: | Adamo, Marianna, Pagnesi, Matteo, Ghizzoni, Giulia, Estévez‐Loureiro, Rodrigo, Raposeiras‐Roubin, Sergio, Tomasoni, Daniela, Stolfo, Davide, Sinagra, Gianfranco, Popolo Rubbio, Antonio, Bedogni, Francesco, De Marco, Federico, Giannini, Cristina, Petronio, Anna Sonia, Stazzoni, Laura, Benito‐González, Tomás, Fernández‐Vázquez, Felipe, Garrote‐Coloma, Carmen, Godino, Cosmo, Agricola, Eustachio, Munafò, Andrea |
| Source: | European Journal of Heart Failure; Nov2022, Vol. 24 Issue 11, p2175-2184, 10p, 5 Charts, 6 Graphs |
| Subject Terms: | MITRAL valve, MITRAL valve insufficiency, SYSTOLIC blood pressure, LEFT heart atrium, PULMONARY artery |
| Abstract: | Aim: To evaluate short‐term changes in tricuspid regurgitation (TR) after transcatheter edge‐to‐edge mitral valve repair (M‐TEER) in secondary mitral regurgitation (SMR), their predictors and impact on mortality. Methods and results: This is a retrospective analysis of SMR patients undergoing successful M‐TEER (post‐procedural mitral regurgitation ≤2+) at 13 European centres. Among 503 patients evaluated 79 (interquartile range [IQR] 40–152) days after M‐TEER, 173 (35%) showed ≥1 degree of TR improvement, 97 (19%) had worsening of TR, and 233 (46%) remained unchanged. Smaller baseline left atrial diameter and residual mitral regurgitation 0/1+ were independent predictors of TR ≤2+ after M‐TEER. There was a significant association between TR changes and New York Heart Association class and pulmonary artery systolic pressure decrease at echocardiographic re‐assessment. At a median follow‐up of 590 (IQR 209–1103) days from short‐term echocardiographic re‐assessment, all‐cause mortality was lower in patients with improved compared to those with unchanged/worsened TR (29.6% vs. 42.3% at 3 years; log‐rank p = 0.034). Baseline TR severity was not associated with mortality, whereas TR 0/1+ and 2+ at short‐term follow‐up was associated with lower all‐cause mortality compared to TR 3/4+ (30.6% and 35.6% vs. 55.6% at 3 years; p < 0.001). A TR ≤2+ after M‐TEER was independently associated with a 42% decreased risk of mortality (p = 0.011). Conclusion: More than one third of patients with SMR undergoing successful M‐TEER experienced an improvement in TR. Pre‐procedural TR was not associated with outcome, but a TR ≤2+ at short‐term follow‐up was independently associated with long‐term mortality. Optimal M‐TEER result and a small left atrium were associated with a higher likelihood of TR ≤2+ after M‐TEER. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Evolution of tricuspid regurgitation after transcatheter edge‐to‐edge mitral valve repair for secondary mitral regurgitation and its impact on mortality. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Adamo%2C+Marianna%22">Adamo, Marianna</searchLink><br /><searchLink fieldCode="AR" term="%22Pagnesi%2C+Matteo%22">Pagnesi, Matteo</searchLink><br /><searchLink fieldCode="AR" term="%22Ghizzoni%2C+Giulia%22">Ghizzoni, Giulia</searchLink><br /><searchLink fieldCode="AR" term="%22Estévez‐Loureiro%2C+Rodrigo%22">Estévez‐Loureiro, Rodrigo</searchLink><br /><searchLink fieldCode="AR" term="%22Raposeiras‐Roubin%2C+Sergio%22">Raposeiras‐Roubin, Sergio</searchLink><br /><searchLink fieldCode="AR" term="%22Tomasoni%2C+Daniela%22">Tomasoni, Daniela</searchLink><br /><searchLink fieldCode="AR" term="%22Stolfo%2C+Davide%22">Stolfo, Davide</searchLink><br /><searchLink fieldCode="AR" term="%22Sinagra%2C+Gianfranco%22">Sinagra, Gianfranco</searchLink><br /><searchLink fieldCode="AR" term="%22Popolo+Rubbio%2C+Antonio%22">Popolo Rubbio, Antonio</searchLink><br /><searchLink fieldCode="AR" term="%22Bedogni%2C+Francesco%22">Bedogni, Francesco</searchLink><br /><searchLink fieldCode="AR" term="%22De+Marco%2C+Federico%22">De Marco, Federico</searchLink><br /><searchLink fieldCode="AR" term="%22Giannini%2C+Cristina%22">Giannini, Cristina</searchLink><br /><searchLink fieldCode="AR" term="%22Petronio%2C+Anna+Sonia%22">Petronio, Anna Sonia</searchLink><br /><searchLink fieldCode="AR" term="%22Stazzoni%2C+Laura%22">Stazzoni, Laura</searchLink><br /><searchLink fieldCode="AR" term="%22Benito‐González%2C+Tomás%22">Benito‐González, Tomás</searchLink><br /><searchLink fieldCode="AR" term="%22Fernández‐Vázquez%2C+Felipe%22">Fernández‐Vázquez, Felipe</searchLink><br /><searchLink fieldCode="AR" term="%22Garrote‐Coloma%2C+Carmen%22">Garrote‐Coloma, Carmen</searchLink><br /><searchLink fieldCode="AR" term="%22Godino%2C+Cosmo%22">Godino, Cosmo</searchLink><br /><searchLink fieldCode="AR" term="%22Agricola%2C+Eustachio%22">Agricola, Eustachio</searchLink><br /><searchLink fieldCode="AR" term="%22Munafò%2C+Andrea%22">Munafò, Andrea</searchLink> – Name: TitleSource Label: Source Group: Src Data: European Journal of Heart Failure; Nov2022, Vol. 24 Issue 11, p2175-2184, 10p, 5 Charts, 6 Graphs – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22MITRAL+valve%22">MITRAL valve</searchLink><br /><searchLink fieldCode="DE" term="%22MITRAL+valve+insufficiency%22">MITRAL valve insufficiency</searchLink><br /><searchLink fieldCode="DE" term="%22SYSTOLIC+blood+pressure%22">SYSTOLIC blood pressure</searchLink><br /><searchLink fieldCode="DE" term="%22LEFT+heart+atrium%22">LEFT heart atrium</searchLink><br /><searchLink fieldCode="DE" term="%22PULMONARY+artery%22">PULMONARY artery</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Aim: To evaluate short‐term changes in tricuspid regurgitation (TR) after transcatheter edge‐to‐edge mitral valve repair (M‐TEER) in secondary mitral regurgitation (SMR), their predictors and impact on mortality. Methods and results: This is a retrospective analysis of SMR patients undergoing successful M‐TEER (post‐procedural mitral regurgitation ≤2+) at 13 European centres. Among 503 patients evaluated 79 (interquartile range [IQR] 40–152) days after M‐TEER, 173 (35%) showed ≥1 degree of TR improvement, 97 (19%) had worsening of TR, and 233 (46%) remained unchanged. Smaller baseline left atrial diameter and residual mitral regurgitation 0/1+ were independent predictors of TR ≤2+ after M‐TEER. There was a significant association between TR changes and New York Heart Association class and pulmonary artery systolic pressure decrease at echocardiographic re‐assessment. At a median follow‐up of 590 (IQR 209–1103) days from short‐term echocardiographic re‐assessment, all‐cause mortality was lower in patients with improved compared to those with unchanged/worsened TR (29.6% vs. 42.3% at 3 years; log‐rank p = 0.034). Baseline TR severity was not associated with mortality, whereas TR 0/1+ and 2+ at short‐term follow‐up was associated with lower all‐cause mortality compared to TR 3/4+ (30.6% and 35.6% vs. 55.6% at 3 years; p < 0.001). A TR ≤2+ after M‐TEER was independently associated with a 42% decreased risk of mortality (p = 0.011). Conclusion: More than one third of patients with SMR undergoing successful M‐TEER experienced an improvement in TR. Pre‐procedural TR was not associated with outcome, but a TR ≤2+ at short‐term follow‐up was independently associated with long‐term mortality. Optimal M‐TEER result and a small left atrium were associated with a higher likelihood of TR ≤2+ after M‐TEER. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of European Journal of Heart Failure is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/ejhf.2637 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 2175 Subjects: – SubjectFull: MITRAL valve Type: general – SubjectFull: MITRAL valve insufficiency Type: general – SubjectFull: SYSTOLIC blood pressure Type: general – SubjectFull: LEFT heart atrium Type: general – SubjectFull: PULMONARY artery Type: general Titles: – TitleFull: Evolution of tricuspid regurgitation after transcatheter edge‐to‐edge mitral valve repair for secondary mitral regurgitation and its impact on mortality. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Adamo, Marianna – PersonEntity: Name: NameFull: Pagnesi, Matteo – PersonEntity: Name: NameFull: Ghizzoni, Giulia – PersonEntity: Name: NameFull: Estévez‐Loureiro, Rodrigo – PersonEntity: Name: NameFull: Raposeiras‐Roubin, Sergio – PersonEntity: Name: NameFull: Tomasoni, Daniela – PersonEntity: Name: NameFull: Stolfo, Davide – PersonEntity: Name: NameFull: Sinagra, Gianfranco – PersonEntity: Name: NameFull: Popolo Rubbio, Antonio – PersonEntity: Name: NameFull: Bedogni, Francesco – PersonEntity: Name: NameFull: De Marco, Federico – PersonEntity: Name: NameFull: Giannini, Cristina – PersonEntity: Name: NameFull: Petronio, Anna Sonia – PersonEntity: Name: NameFull: Stazzoni, Laura – PersonEntity: Name: NameFull: Benito‐González, Tomás – PersonEntity: Name: NameFull: Fernández‐Vázquez, Felipe – PersonEntity: Name: NameFull: Garrote‐Coloma, Carmen – PersonEntity: Name: NameFull: Godino, Cosmo – PersonEntity: Name: NameFull: Agricola, Eustachio – PersonEntity: Name: NameFull: Munafò, Andrea IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 13889842 Numbering: – Type: volume Value: 24 – Type: issue Value: 11 Titles: – TitleFull: European Journal of Heart Failure Type: main |
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