Neutrophils play a major role in the destruction of the olfactory epithelium during SARS-CoV-2 infection in hamsters.

Bibliographic Details
Title: Neutrophils play a major role in the destruction of the olfactory epithelium during SARS-CoV-2 infection in hamsters.
Authors: Bourgon, Clara, Albin, Audrey St, Ando-Grard, Ophélie, Da Costa, Bruno, Domain, Roxane, Korkmaz, Brice, Klonjkowski, Bernard, Le Poder, Sophie, Meunier, Nicolas
Source: Cellular & Molecular Life Sciences; Dec2022, Vol. 79 Issue 12, p1-16, 16p
Abstract: The loss of smell (anosmia) related to SARS-CoV-2 infection is one of the most common symptoms of COVID-19. Olfaction starts in the olfactory epithelium mainly composed of olfactory sensory neurons surrounded by supporting cells called sustentacular cells. It is now clear that the loss of smell is related to the massive infection by SARS-CoV-2 of the sustentacular cells in the olfactory epithelium leading to its desquamation. However, the molecular mechanism behind the destabilization of the olfactory epithelium is less clear. Using golden Syrian hamsters infected with an early circulating SARS-CoV-2 strain harboring the D614G mutation in the spike protein; we show here that rather than being related to a first wave of apoptosis as proposed in previous studies, the innate immune cells play a major role in the destruction of the olfactory epithelium. We observed that while apoptosis remains at a low level in the damaged area of the infected epithelium, the latter is invaded by Iba1+ cells, neutrophils and macrophages. By depleting the neutrophil population or blocking the activity of neutrophil elastase-like proteinases, we could reduce the damage induced by the SARS-CoV-2 infection. Surprisingly, the impairment of neutrophil activity led to a decrease in SARS-CoV-2 infection levels in the olfactory epithelium. Our results indicate a counterproductive role of neutrophils leading to the release of infected cells in the lumen of the nasal cavity and thereby enhanced spreading of the virus in the early phase of the SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]
Copyright of Cellular & Molecular Life Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edb&genre=article&issn=1420682X&ISBN=&volume=79&issue=12&date=20221201&spage=1&pages=1-16&title=Cellular & Molecular Life Sciences&atitle=Neutrophils%20play%20a%20major%20role%20in%20the%20destruction%20of%20the%20olfactory%20epithelium%20during%20SARS-CoV-2%20infection%20in%20hamsters.&aulast=Bourgon%2C%20Clara&id=DOI:10.1007/s00018-022-04643-1
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: edb
DbLabel: Complementary Index
An: 160575002
RelevancyScore: 957
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 957.281066894531
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Neutrophils play a major role in the destruction of the olfactory epithelium during SARS-CoV-2 infection in hamsters.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Bourgon%2C+Clara%22">Bourgon, Clara</searchLink><br /><searchLink fieldCode="AR" term="%22Albin%2C+Audrey+St%22">Albin, Audrey St</searchLink><br /><searchLink fieldCode="AR" term="%22Ando-Grard%2C+Ophélie%22">Ando-Grard, Ophélie</searchLink><br /><searchLink fieldCode="AR" term="%22Da+Costa%2C+Bruno%22">Da Costa, Bruno</searchLink><br /><searchLink fieldCode="AR" term="%22Domain%2C+Roxane%22">Domain, Roxane</searchLink><br /><searchLink fieldCode="AR" term="%22Korkmaz%2C+Brice%22">Korkmaz, Brice</searchLink><br /><searchLink fieldCode="AR" term="%22Klonjkowski%2C+Bernard%22">Klonjkowski, Bernard</searchLink><br /><searchLink fieldCode="AR" term="%22Le+Poder%2C+Sophie%22">Le Poder, Sophie</searchLink><br /><searchLink fieldCode="AR" term="%22Meunier%2C+Nicolas%22">Meunier, Nicolas</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Cellular & Molecular Life Sciences; Dec2022, Vol. 79 Issue 12, p1-16, 16p
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The loss of smell (anosmia) related to SARS-CoV-2 infection is one of the most common symptoms of COVID-19. Olfaction starts in the olfactory epithelium mainly composed of olfactory sensory neurons surrounded by supporting cells called sustentacular cells. It is now clear that the loss of smell is related to the massive infection by SARS-CoV-2 of the sustentacular cells in the olfactory epithelium leading to its desquamation. However, the molecular mechanism behind the destabilization of the olfactory epithelium is less clear. Using golden Syrian hamsters infected with an early circulating SARS-CoV-2 strain harboring the D614G mutation in the spike protein; we show here that rather than being related to a first wave of apoptosis as proposed in previous studies, the innate immune cells play a major role in the destruction of the olfactory epithelium. We observed that while apoptosis remains at a low level in the damaged area of the infected epithelium, the latter is invaded by Iba1<superscript>+</superscript> cells, neutrophils and macrophages. By depleting the neutrophil population or blocking the activity of neutrophil elastase-like proteinases, we could reduce the damage induced by the SARS-CoV-2 infection. Surprisingly, the impairment of neutrophil activity led to a decrease in SARS-CoV-2 infection levels in the olfactory epithelium. Our results indicate a counterproductive role of neutrophils leading to the release of infected cells in the lumen of the nasal cavity and thereby enhanced spreading of the virus in the early phase of the SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Cellular & Molecular Life Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=160575002
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00018-022-04643-1
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 16
        StartPage: 1
    Titles:
      – TitleFull: Neutrophils play a major role in the destruction of the olfactory epithelium during SARS-CoV-2 infection in hamsters.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Bourgon, Clara
      – PersonEntity:
          Name:
            NameFull: Albin, Audrey St
      – PersonEntity:
          Name:
            NameFull: Ando-Grard, Ophélie
      – PersonEntity:
          Name:
            NameFull: Da Costa, Bruno
      – PersonEntity:
          Name:
            NameFull: Domain, Roxane
      – PersonEntity:
          Name:
            NameFull: Korkmaz, Brice
      – PersonEntity:
          Name:
            NameFull: Klonjkowski, Bernard
      – PersonEntity:
          Name:
            NameFull: Le Poder, Sophie
      – PersonEntity:
          Name:
            NameFull: Meunier, Nicolas
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: Dec2022
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-print
              Value: 1420682X
          Numbering:
            – Type: volume
              Value: 79
            – Type: issue
              Value: 12
          Titles:
            – TitleFull: Cellular & Molecular Life Sciences
              Type: main
ResultId 1