Intensive Periodontal Treatment Does Not Affect the Lipid Profile and Endothelial Function of Patients with Type 2 Diabetes: A Randomized Clinical Trial.
| Title: | Intensive Periodontal Treatment Does Not Affect the Lipid Profile and Endothelial Function of Patients with Type 2 Diabetes: A Randomized Clinical Trial. |
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| Authors: | Rapone, Biagio, Ferrara, Elisabetta, Qorri, Erda, Quadri, Mir Faeq Ali, Dipalma, Gianna, Mancini, Antonio, Del Fabbro, Massimo, Scarano, Antonio, Tartaglia, Gianluca, Inchingolo, Francesco |
| Source: | Biomedicines; Oct2022, Vol. 10 Issue 10, pN.PAG-N.PAG, 14p |
| Subject Terms: | TYPE 2 diabetes, CLINICAL trials, LDL cholesterol, DYSLIPIDEMIA, PERIODONTITIS, LIPIDS, BLOOD cholesterol |
| Abstract: | Background: Local eradication of periodontal infection could potentially have a much broader impact on the diabetic condition by also contributing to the modification of the lipid profile, which is directly compromised in the alteration of endothelium-dependent vasodilation. The aim of this trial was to assess the benefits of intensive periodontal treatment (IPT) on the lipid profile and endothelial function of diabetic patients. Methods: This was a 6-month, randomized controlled trial involving diabetic patients with generalized periodontitis. The study group comprised 290 individuals who were randomly assigned to receive Intensive Periodontal Treatment (IPT, Intervention Group) or conventional adult prophylaxis (Control Periodontal Treatment, CPT, Control Group). Outcomes encompassed lipid profile involving serum total cholesterol, serum triglyceride, low-density lipoprotein cholesterol, high-density lipo-protein cholesterol, and flow-mediated vasodilation (FMD) as an index of endothelium-dependent vasodilation (primary outcomes); periodontal indices and high-sensitive C-reactive protein were evaluated at baseline, 3 and 6 months after periodontal treatment. Results: An increase in endothelium-dependent flow-mediated dilatation (FMD) was observed in the Intensive Periodontal Treatment group in comparison with Control (p < 0.001), but results are not statistically different. There were no differences in lipid profile in individuals of both groups. Conclusions: An intensive periodontal treatment might improve endothelial function, suggesting a direct beneficial effect on the vasculature, possibly mediated by systemic inflammatory reduction. However, no statistically significant differences between groups were observed, and no benefits were proved on lipid profile. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Intensive Periodontal Treatment Does Not Affect the Lipid Profile and Endothelial Function of Patients with Type 2 Diabetes: A Randomized Clinical Trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rapone%2C+Biagio%22">Rapone, Biagio</searchLink><br /><searchLink fieldCode="AR" term="%22Ferrara%2C+Elisabetta%22">Ferrara, Elisabetta</searchLink><br /><searchLink fieldCode="AR" term="%22Qorri%2C+Erda%22">Qorri, Erda</searchLink><br /><searchLink fieldCode="AR" term="%22Quadri%2C+Mir+Faeq+Ali%22">Quadri, Mir Faeq Ali</searchLink><br /><searchLink fieldCode="AR" term="%22Dipalma%2C+Gianna%22">Dipalma, Gianna</searchLink><br /><searchLink fieldCode="AR" term="%22Mancini%2C+Antonio%22">Mancini, Antonio</searchLink><br /><searchLink fieldCode="AR" term="%22Del+Fabbro%2C+Massimo%22">Del Fabbro, Massimo</searchLink><br /><searchLink fieldCode="AR" term="%22Scarano%2C+Antonio%22">Scarano, Antonio</searchLink><br /><searchLink fieldCode="AR" term="%22Tartaglia%2C+Gianluca%22">Tartaglia, Gianluca</searchLink><br /><searchLink fieldCode="AR" term="%22Inchingolo%2C+Francesco%22">Inchingolo, Francesco</searchLink> – Name: TitleSource Label: Source Group: Src Data: Biomedicines; Oct2022, Vol. 10 Issue 10, pN.PAG-N.PAG, 14p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22TYPE+2+diabetes%22">TYPE 2 diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22CLINICAL+trials%22">CLINICAL trials</searchLink><br /><searchLink fieldCode="DE" term="%22LDL+cholesterol%22">LDL cholesterol</searchLink><br /><searchLink fieldCode="DE" term="%22DYSLIPIDEMIA%22">DYSLIPIDEMIA</searchLink><br /><searchLink fieldCode="DE" term="%22PERIODONTITIS%22">PERIODONTITIS</searchLink><br /><searchLink fieldCode="DE" term="%22LIPIDS%22">LIPIDS</searchLink><br /><searchLink fieldCode="DE" term="%22BLOOD+cholesterol%22">BLOOD cholesterol</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Local eradication of periodontal infection could potentially have a much broader impact on the diabetic condition by also contributing to the modification of the lipid profile, which is directly compromised in the alteration of endothelium-dependent vasodilation. The aim of this trial was to assess the benefits of intensive periodontal treatment (IPT) on the lipid profile and endothelial function of diabetic patients. Methods: This was a 6-month, randomized controlled trial involving diabetic patients with generalized periodontitis. The study group comprised 290 individuals who were randomly assigned to receive Intensive Periodontal Treatment (IPT, Intervention Group) or conventional adult prophylaxis (Control Periodontal Treatment, CPT, Control Group). Outcomes encompassed lipid profile involving serum total cholesterol, serum triglyceride, low-density lipoprotein cholesterol, high-density lipo-protein cholesterol, and flow-mediated vasodilation (FMD) as an index of endothelium-dependent vasodilation (primary outcomes); periodontal indices and high-sensitive C-reactive protein were evaluated at baseline, 3 and 6 months after periodontal treatment. Results: An increase in endothelium-dependent flow-mediated dilatation (FMD) was observed in the Intensive Periodontal Treatment group in comparison with Control (p < 0.001), but results are not statistically different. There were no differences in lipid profile in individuals of both groups. Conclusions: An intensive periodontal treatment might improve endothelial function, suggesting a direct beneficial effect on the vasculature, possibly mediated by systemic inflammatory reduction. However, no statistically significant differences between groups were observed, and no benefits were proved on lipid profile. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Biomedicines is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/biomedicines10102524 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: N.PAG Subjects: – SubjectFull: TYPE 2 diabetes Type: general – SubjectFull: CLINICAL trials Type: general – SubjectFull: LDL cholesterol Type: general – SubjectFull: DYSLIPIDEMIA Type: general – SubjectFull: PERIODONTITIS Type: general – SubjectFull: LIPIDS Type: general – SubjectFull: BLOOD cholesterol Type: general Titles: – TitleFull: Intensive Periodontal Treatment Does Not Affect the Lipid Profile and Endothelial Function of Patients with Type 2 Diabetes: A Randomized Clinical Trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rapone, Biagio – PersonEntity: Name: NameFull: Ferrara, Elisabetta – PersonEntity: Name: NameFull: Qorri, Erda – PersonEntity: Name: NameFull: Quadri, Mir Faeq Ali – PersonEntity: Name: NameFull: Dipalma, Gianna – PersonEntity: Name: NameFull: Mancini, Antonio – PersonEntity: Name: NameFull: Del Fabbro, Massimo – PersonEntity: Name: NameFull: Scarano, Antonio – PersonEntity: Name: NameFull: Tartaglia, Gianluca – PersonEntity: Name: NameFull: Inchingolo, Francesco IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 22279059 Numbering: – Type: volume Value: 10 – Type: issue Value: 10 Titles: – TitleFull: Biomedicines Type: main |
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