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Metagenomic profiles of Dermacentor tick pathogens from across Mongolia, using next generation sequencing.

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Title: Metagenomic profiles of Dermacentor tick pathogens from across Mongolia, using next generation sequencing.
Authors: Altantogtokh, Doniddemberel, Lilak, Abigail A., Takhampunya, Ratree, Sakolvaree, Jira, Chanarat, Nitima, Matulis, Graham, Poole-Smith, Betty Katherine, Boldbaatar, Bazartseren, Davidson, Silas, Hertz, Jeffrey, Bolorchimeg, Buyandelger, Tsogbadrakh, Nyamdorj, Fiorenzano, Jodi M., Lindroth, Erica J., von Fricken, Michael E.
Source: Frontiers in Microbiology; 8/10/2022, Vol. 13, p1-14, 14p
Subject Terms: TICKS, DERMACENTOR, RICKETTSIA, DNA sequencing, METAGENOMICS, TICK-borne diseases, ANAPLASMOSIS
Geographic Terms: MONGOLIA
Abstract: Tick-borne diseases are a major public health concern in Mongolia. Nomadic pastoralists, which make up ~ 26% of Mongolia’s population, are at an increased risk of both tick bite exposure and economic loss associated with clinical disease in herds. This study sought to further characterize tick-borne pathogens present in Dermacentor ticks (n = 1,773) sampled in 2019 from 15 of Mongolia’s 21 aimags (provinces). The ticks were morphologically identified and sorted into 377 pools which were then screened using Next-Generation Sequencing paired with confirmatory PCR and DNA sequence analysis. Rickettsia spp. were detected in 88.33% of pools, while Anaplasma spp. and Bartonella spp. were detected in 3.18 and 0.79% of pools, respectively. Khentii had the highest infection rate for Rickettsia spp. (76.61%; CI: 34.65–94.79%), while Arkhangai had the highest infection rate for Anaplasma spp. (7.79%; CI:4.04–13.72%). The exclusive detection of Anaplasma spp. in tick pools collected from livestock supports previous work in this area that suggests livestock play a significant role in disease maintenance. The detection of Anaplasma, Bartonella, and Rickettsia demonstrates a heightened risk for infection throughout Mongolia, with this study, to our knowledge, documenting the first detection of Bartonella melophagi in ticks collected in Mongolia. Further research deploying NGS methods is needed to characterize tick-borne pathogens in other endemic tick species found in Mongolia, including Hyalomma asiaticum and Ixodes persulcatus. [ABSTRACT FROM AUTHOR]
Copyright of Frontiers in Microbiology is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Metagenomic profiles of Dermacentor tick pathogens from across Mongolia, using next generation sequencing.
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  Data: <searchLink fieldCode="AR" term="%22Altantogtokh%2C+Doniddemberel%22">Altantogtokh, Doniddemberel</searchLink><br /><searchLink fieldCode="AR" term="%22Lilak%2C+Abigail+A%2E%22">Lilak, Abigail A.</searchLink><br /><searchLink fieldCode="AR" term="%22Takhampunya%2C+Ratree%22">Takhampunya, Ratree</searchLink><br /><searchLink fieldCode="AR" term="%22Sakolvaree%2C+Jira%22">Sakolvaree, Jira</searchLink><br /><searchLink fieldCode="AR" term="%22Chanarat%2C+Nitima%22">Chanarat, Nitima</searchLink><br /><searchLink fieldCode="AR" term="%22Matulis%2C+Graham%22">Matulis, Graham</searchLink><br /><searchLink fieldCode="AR" term="%22Poole-Smith%2C+Betty+Katherine%22">Poole-Smith, Betty Katherine</searchLink><br /><searchLink fieldCode="AR" term="%22Boldbaatar%2C+Bazartseren%22">Boldbaatar, Bazartseren</searchLink><br /><searchLink fieldCode="AR" term="%22Davidson%2C+Silas%22">Davidson, Silas</searchLink><br /><searchLink fieldCode="AR" term="%22Hertz%2C+Jeffrey%22">Hertz, Jeffrey</searchLink><br /><searchLink fieldCode="AR" term="%22Bolorchimeg%2C+Buyandelger%22">Bolorchimeg, Buyandelger</searchLink><br /><searchLink fieldCode="AR" term="%22Tsogbadrakh%2C+Nyamdorj%22">Tsogbadrakh, Nyamdorj</searchLink><br /><searchLink fieldCode="AR" term="%22Fiorenzano%2C+Jodi+M%2E%22">Fiorenzano, Jodi M.</searchLink><br /><searchLink fieldCode="AR" term="%22Lindroth%2C+Erica+J%2E%22">Lindroth, Erica J.</searchLink><br /><searchLink fieldCode="AR" term="%22von+Fricken%2C+Michael+E%2E%22">von Fricken, Michael E.</searchLink>
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  Data: Frontiers in Microbiology; 8/10/2022, Vol. 13, p1-14, 14p
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  Data: <searchLink fieldCode="DE" term="%22TICKS%22">TICKS</searchLink><br /><searchLink fieldCode="DE" term="%22DERMACENTOR%22">DERMACENTOR</searchLink><br /><searchLink fieldCode="DE" term="%22RICKETTSIA%22">RICKETTSIA</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+sequencing%22">DNA sequencing</searchLink><br /><searchLink fieldCode="DE" term="%22METAGENOMICS%22">METAGENOMICS</searchLink><br /><searchLink fieldCode="DE" term="%22TICK-borne+diseases%22">TICK-borne diseases</searchLink><br /><searchLink fieldCode="DE" term="%22ANAPLASMOSIS%22">ANAPLASMOSIS</searchLink>
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Tick-borne diseases are a major public health concern in Mongolia. Nomadic pastoralists, which make up ~ 26% of Mongolia’s population, are at an increased risk of both tick bite exposure and economic loss associated with clinical disease in herds. This study sought to further characterize tick-borne pathogens present in Dermacentor ticks (n = 1,773) sampled in 2019 from 15 of Mongolia’s 21 aimags (provinces). The ticks were morphologically identified and sorted into 377 pools which were then screened using Next-Generation Sequencing paired with confirmatory PCR and DNA sequence analysis. Rickettsia spp. were detected in 88.33% of pools, while Anaplasma spp. and Bartonella spp. were detected in 3.18 and 0.79% of pools, respectively. Khentii had the highest infection rate for Rickettsia spp. (76.61%; CI: 34.65–94.79%), while Arkhangai had the highest infection rate for Anaplasma spp. (7.79%; CI:4.04–13.72%). The exclusive detection of Anaplasma spp. in tick pools collected from livestock supports previous work in this area that suggests livestock play a significant role in disease maintenance. The detection of Anaplasma, Bartonella, and Rickettsia demonstrates a heightened risk for infection throughout Mongolia, with this study, to our knowledge, documenting the first detection of Bartonella melophagi in ticks collected in Mongolia. Further research deploying NGS methods is needed to characterize tick-borne pathogens in other endemic tick species found in Mongolia, including Hyalomma asiaticum and Ixodes persulcatus. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Frontiers in Microbiology is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3389/fmicb.2022.946631
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      – Code: eng
        Text: English
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        PageCount: 14
        StartPage: 1
    Subjects:
      – SubjectFull: MONGOLIA
        Type: general
      – SubjectFull: TICKS
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      – SubjectFull: DERMACENTOR
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      – SubjectFull: ANAPLASMOSIS
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