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Heterogeneity of PD-MCI in Candidates to Subthalamic Deep Brain Stimulation: Associated Cortical and Subcortical Modifications.

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Title: Heterogeneity of PD-MCI in Candidates to Subthalamic Deep Brain Stimulation: Associated Cortical and Subcortical Modifications.
Authors: Devignes, Quentin, Daoudi, Sami, Viard, Romain, Lopes, Renaud, Betrouni, Nacim, Kuchcinski, Gregory, Rolland, Anne-Sophie, Moreau, Caroline, Defebvre, Luc, Bardinet, Eric, Bonnet, Marie, Brefel-Courbon, Christine, Delmaire, Christine, El Mountassir, Fouzia, Fluchère, Frédérique, Fradet, Anne, Giordana, Caroline, Hainque, Elodie, Houvenaghel, Jean-François, Jarraya, Béchir
Source: Journal of Parkinson's Disease; 2022, Vol. 12 Issue 5, p1507-1526, 20p
Subject Terms: DEEP brain stimulation, SUBTHALAMIC nucleus, CAUDATE nucleus, CEREBRAL cortical thinning, MILD cognitive impairment, PARKINSON'S disease
Abstract: Background: Parkinson's disease mild cognitive impairment (PD-MCI) is frequent and heterogenous. There is no consensus about its influence on subthalamic deep brain stimulation (STN-DBS) outcomes. Objective: To determine the prevalence of PD-MCI and its subtypes in candidates to STN-DBS. Secondarily, we sought to identify MRI structural markers associated with cognitive impairment in these subgroups. Methods: Baseline data from the French multicentric PREDISTIM cohort were used. Candidates to STN-DBS were classified according to their cognitive performance in normal cognition (PD-NC) or PD-MCI. The latter included frontostriatal (PD-FS) and posterior cortical (PD-PC) subtypes. Between-group comparisons were performed on demographical and clinical variables as well as on T1-weighted MRI sequences at the cortical and subcortical levels. Results: 320 patients were included: 167 (52%) PD-NC and 153 (48%) PD-MCI patients. The latter group included 123 (80%) PD-FS and 30 (20%) PD-PC patients. There was no between-group difference regarding demographic and clinical variables. PD-PC patients had significantly lower global efficiency than PD-FS patients and significantly worse performance on visuospatial functions, episodic memory, and language. Compared to PD-NC, PD-MCI patients had cortical thinning and radiomic-based changes in the left caudate nucleus and hippocampus. There were no significant differences between the PD-MCI subtypes. Conclusion: Among the candidates to STN-DBS, a significant proportion has PD-MCI which is associated with cortical and subcortical alterations. Some PD-MCI patients have posterior cortical deficits, a subtype known to be at higher risk of dementia. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Parkinson's Disease is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Heterogeneity of PD-MCI in Candidates to Subthalamic Deep Brain Stimulation: Associated Cortical and Subcortical Modifications.
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  Data: <searchLink fieldCode="AR" term="%22Devignes%2C+Quentin%22">Devignes, Quentin</searchLink><br /><searchLink fieldCode="AR" term="%22Daoudi%2C+Sami%22">Daoudi, Sami</searchLink><br /><searchLink fieldCode="AR" term="%22Viard%2C+Romain%22">Viard, Romain</searchLink><br /><searchLink fieldCode="AR" term="%22Lopes%2C+Renaud%22">Lopes, Renaud</searchLink><br /><searchLink fieldCode="AR" term="%22Betrouni%2C+Nacim%22">Betrouni, Nacim</searchLink><br /><searchLink fieldCode="AR" term="%22Kuchcinski%2C+Gregory%22">Kuchcinski, Gregory</searchLink><br /><searchLink fieldCode="AR" term="%22Rolland%2C+Anne-Sophie%22">Rolland, Anne-Sophie</searchLink><br /><searchLink fieldCode="AR" term="%22Moreau%2C+Caroline%22">Moreau, Caroline</searchLink><br /><searchLink fieldCode="AR" term="%22Defebvre%2C+Luc%22">Defebvre, Luc</searchLink><br /><searchLink fieldCode="AR" term="%22Bardinet%2C+Eric%22">Bardinet, Eric</searchLink><br /><searchLink fieldCode="AR" term="%22Bonnet%2C+Marie%22">Bonnet, Marie</searchLink><br /><searchLink fieldCode="AR" term="%22Brefel-Courbon%2C+Christine%22">Brefel-Courbon, Christine</searchLink><br /><searchLink fieldCode="AR" term="%22Delmaire%2C+Christine%22">Delmaire, Christine</searchLink><br /><searchLink fieldCode="AR" term="%22El+Mountassir%2C+Fouzia%22">El Mountassir, Fouzia</searchLink><br /><searchLink fieldCode="AR" term="%22Fluchère%2C+Frédérique%22">Fluchère, Frédérique</searchLink><br /><searchLink fieldCode="AR" term="%22Fradet%2C+Anne%22">Fradet, Anne</searchLink><br /><searchLink fieldCode="AR" term="%22Giordana%2C+Caroline%22">Giordana, Caroline</searchLink><br /><searchLink fieldCode="AR" term="%22Hainque%2C+Elodie%22">Hainque, Elodie</searchLink><br /><searchLink fieldCode="AR" term="%22Houvenaghel%2C+Jean-François%22">Houvenaghel, Jean-François</searchLink><br /><searchLink fieldCode="AR" term="%22Jarraya%2C+Béchir%22">Jarraya, Béchir</searchLink>
– Name: TitleSource
  Label: Source
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  Data: Journal of Parkinson's Disease; 2022, Vol. 12 Issue 5, p1507-1526, 20p
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22DEEP+brain+stimulation%22">DEEP brain stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22SUBTHALAMIC+nucleus%22">SUBTHALAMIC nucleus</searchLink><br /><searchLink fieldCode="DE" term="%22CAUDATE+nucleus%22">CAUDATE nucleus</searchLink><br /><searchLink fieldCode="DE" term="%22CEREBRAL+cortical+thinning%22">CEREBRAL cortical thinning</searchLink><br /><searchLink fieldCode="DE" term="%22MILD+cognitive+impairment%22">MILD cognitive impairment</searchLink><br /><searchLink fieldCode="DE" term="%22PARKINSON'S+disease%22">PARKINSON'S disease</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Parkinson's disease mild cognitive impairment (PD-MCI) is frequent and heterogenous. There is no consensus about its influence on subthalamic deep brain stimulation (STN-DBS) outcomes. Objective: To determine the prevalence of PD-MCI and its subtypes in candidates to STN-DBS. Secondarily, we sought to identify MRI structural markers associated with cognitive impairment in these subgroups. Methods: Baseline data from the French multicentric PREDISTIM cohort were used. Candidates to STN-DBS were classified according to their cognitive performance in normal cognition (PD-NC) or PD-MCI. The latter included frontostriatal (PD-FS) and posterior cortical (PD-PC) subtypes. Between-group comparisons were performed on demographical and clinical variables as well as on T1-weighted MRI sequences at the cortical and subcortical levels. Results: 320 patients were included: 167 (52%) PD-NC and 153 (48%) PD-MCI patients. The latter group included 123 (80%) PD-FS and 30 (20%) PD-PC patients. There was no between-group difference regarding demographic and clinical variables. PD-PC patients had significantly lower global efficiency than PD-FS patients and significantly worse performance on visuospatial functions, episodic memory, and language. Compared to PD-NC, PD-MCI patients had cortical thinning and radiomic-based changes in the left caudate nucleus and hippocampus. There were no significant differences between the PD-MCI subtypes. Conclusion: Among the candidates to STN-DBS, a significant proportion has PD-MCI which is associated with cortical and subcortical alterations. Some PD-MCI patients have posterior cortical deficits, a subtype known to be at higher risk of dementia. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Parkinson's Disease is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3233/JPD-223232
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        Text: English
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      – SubjectFull: DEEP brain stimulation
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      – SubjectFull: SUBTHALAMIC nucleus
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      – SubjectFull: CAUDATE nucleus
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      – SubjectFull: MILD cognitive impairment
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      – SubjectFull: PARKINSON'S disease
        Type: general
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      – TitleFull: Heterogeneity of PD-MCI in Candidates to Subthalamic Deep Brain Stimulation: Associated Cortical and Subcortical Modifications.
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              Text: 2022
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