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Long-Term Mastication Changed Salivary Metabolomic Profiles.

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Title: Long-Term Mastication Changed Salivary Metabolomic Profiles.
Authors: Saeki, Yoji, Takenouchi, Akane, Otani, Etsuyo, Kim, Minji, Aizawa, Yumi, Aita, Yasuko, Tomita, Atsumi, Sugimoto, Masahiro, Matsukubo, Takashi
Source: Metabolites (2218-1989); Jul2022, Vol. 12 Issue 7, pN.PAG-N.PAG, 9p
Subject Terms: SALIVA, MASTICATION, METABOLOMICS, CITRATES, FALSE discovery rate, ORAL hygiene, CHEWING gum
Abstract: Saliva is an ideal biofluid for monitoring oral and systemic health. Repeated mastication is a typical physical stimulus that improves salivary flow and oral hygiene. Recent metabolomic studies have shown the potential of salivary metabolomic components for various disease monitoring systems. Here, we evaluated the effect of long-term mastication on salivary metabolomic profiles. Young women with good oral hygiene (20.8 ± 0.3 years, n = 17) participated. They were prohibited from chewing gum during control periods (4 weeks each) and were instructed to chew a piece of gum base seven times a day for 10 min each time during the intervention period. Paired samples of unstimulated whole saliva collected on the last day of the control and intervention period were compared. Liquid chromatography–time-of-flight mass spectrometry successfully quantified 85 metabolites, of which 41 showed significant differences (p < 0.05, Wilcoxon paired test corrected by false discovery rate). Except for a few metabolites, such as citrate, most metabolites showed lower concentrations after the intervention. The pathways related to glycogenic amino acids, such as alanine, arginine, and glutamine, altered considerably. This study suggests that long-term mastication induces unstimulated salivary component-level changes. [ABSTRACT FROM AUTHOR]
Copyright of Metabolites (2218-1989) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Long-Term Mastication Changed Salivary Metabolomic Profiles.
– Name: Author
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Saeki%2C+Yoji%22&quot;&gt;Saeki, Yoji&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Takenouchi%2C+Akane%22&quot;&gt;Takenouchi, Akane&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Otani%2C+Etsuyo%22&quot;&gt;Otani, Etsuyo&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kim%2C+Minji%22&quot;&gt;Kim, Minji&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Aizawa%2C+Yumi%22&quot;&gt;Aizawa, Yumi&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Aita%2C+Yasuko%22&quot;&gt;Aita, Yasuko&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tomita%2C+Atsumi%22&quot;&gt;Tomita, Atsumi&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sugimoto%2C+Masahiro%22&quot;&gt;Sugimoto, Masahiro&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Matsukubo%2C+Takashi%22&quot;&gt;Matsukubo, Takashi&lt;/searchLink&gt;
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  Data: Metabolites (2218-1989); Jul2022, Vol. 12 Issue 7, pN.PAG-N.PAG, 9p
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22SALIVA%22&quot;&gt;SALIVA&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22MASTICATION%22&quot;&gt;MASTICATION&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22METABOLOMICS%22&quot;&gt;METABOLOMICS&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22CITRATES%22&quot;&gt;CITRATES&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22FALSE+discovery+rate%22&quot;&gt;FALSE discovery rate&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22ORAL+hygiene%22&quot;&gt;ORAL hygiene&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22CHEWING+gum%22&quot;&gt;CHEWING gum&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Saliva is an ideal biofluid for monitoring oral and systemic health. Repeated mastication is a typical physical stimulus that improves salivary flow and oral hygiene. Recent metabolomic studies have shown the potential of salivary metabolomic components for various disease monitoring systems. Here, we evaluated the effect of long-term mastication on salivary metabolomic profiles. Young women with good oral hygiene (20.8 &#177; 0.3 years, n = 17) participated. They were prohibited from chewing gum during control periods (4 weeks each) and were instructed to chew a piece of gum base seven times a day for 10 min each time during the intervention period. Paired samples of unstimulated whole saliva collected on the last day of the control and intervention period were compared. Liquid chromatography–time-of-flight mass spectrometry successfully quantified 85 metabolites, of which 41 showed significant differences (p &lt; 0.05, Wilcoxon paired test corrected by false discovery rate). Except for a few metabolites, such as citrate, most metabolites showed lower concentrations after the intervention. The pathways related to glycogenic amino acids, such as alanine, arginine, and glutamine, altered considerably. This study suggests that long-term mastication induces unstimulated salivary component-level changes. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Metabolites (2218-1989) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder&#39;s express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.3390/metabo12070660
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: N.PAG
    Subjects:
      – SubjectFull: SALIVA
        Type: general
      – SubjectFull: MASTICATION
        Type: general
      – SubjectFull: METABOLOMICS
        Type: general
      – SubjectFull: CITRATES
        Type: general
      – SubjectFull: FALSE discovery rate
        Type: general
      – SubjectFull: ORAL hygiene
        Type: general
      – SubjectFull: CHEWING gum
        Type: general
    Titles:
      – TitleFull: Long-Term Mastication Changed Salivary Metabolomic Profiles.
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            NameFull: Saeki, Yoji
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            NameFull: Takenouchi, Akane
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            NameFull: Otani, Etsuyo
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            NameFull: Kim, Minji
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            NameFull: Aizawa, Yumi
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            NameFull: Sugimoto, Masahiro
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            – D: 01
              M: 07
              Text: Jul2022
              Type: published
              Y: 2022
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              Value: 12
            – Type: issue
              Value: 7
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            – TitleFull: Metabolites (2218-1989)
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