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Genome-Wide Association Study for Chronic Hepatitis B Infection in the Thai Population.

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Title: Genome-Wide Association Study for Chronic Hepatitis B Infection in the Thai Population.
Authors: Ashouri, Saeideh, Khor, Seik-Soon, Hitomi, Yuki, Sawai, Hiromi, Nishida, Nao, Sugiyama, Masaya, Kawai, Yosuke, Posuwan, Nawarat, Tangkijvanich, Pisit, Komolmit, Piyawat, Tsuiji, Makoto, Shotelersuk, Vorasuk, Poovorawan, Yong, Mizokami, Masashi, Tokunaga, Katsushi
Source: Frontiers in Genetics; 6/13/2022, Vol. 13, p1-10, 10p
Subject Terms: CHRONIC hepatitis B, GENOME-wide association studies, GENETIC variation, SINGLE nucleotide polymorphisms, HEPATITIS B virus
Abstract: To identify novel host genetic variants that predispose to hepatitis B virus (HBV) persistence, we performed the first genome-wide association study in the Thai population involving 318 cases of chronic hepatitis B and 309 healthy controls after quality control measures. We detected the genome-wide significant association of the HLA class II region (HLA-DPA1/DPB1 , rs7770370, p -value = 7.71 × 10−10, OR = 0.49) with HBV chronicity. Subsequent HLA allele imputation revealed HLA-DPA1*01:03 (Pc = 1.21 × 10−6, OR = 0.53), HLA-DPB1*02:01 (Pc = 2.17 × 10−3, OR = 0.50), and HLA-DQB1*06:09 (Pc = 2.17 × 10−2, OR = 0.07) as protective alleles, and HLA-DPA1*02:02 (Pc = 6.32 × 10−5, OR = 1.63), HLA-DPB1*05:01 (Pc = 1.13 × 10−4, OR = 1.72), HLA-DPB1*13:01 (Pc = 4.68 × 10−2, OR = 1.60), and HLA-DQB1*03:03 (Pc = 1.11 × 10−3, OR = 1.84) as risk alleles for HBV persistence. We also detected suggestive associations in the PLSCR1 (rs35766154), PDLIM5 (rs62321986), SGPL1 (rs144998273), and MGST1 (rs1828682) loci. Among single-nucleotide polymorphisms in the PLSCR1 locus, rs1061307 was identified as the primary functional variant by in silico/in vitro functional analysis. In addition to replicating the association of the HLA class II region, we detected novel candidate loci that provide new insights into the pathophysiology of chronic hepatitis B. [ABSTRACT FROM AUTHOR]
Copyright of Frontiers in Genetics is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: Genome-Wide Association Study for Chronic Hepatitis B Infection in the Thai Population.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Ashouri%2C+Saeideh%22">Ashouri, Saeideh</searchLink><br /><searchLink fieldCode="AR" term="%22Khor%2C+Seik-Soon%22">Khor, Seik-Soon</searchLink><br /><searchLink fieldCode="AR" term="%22Hitomi%2C+Yuki%22">Hitomi, Yuki</searchLink><br /><searchLink fieldCode="AR" term="%22Sawai%2C+Hiromi%22">Sawai, Hiromi</searchLink><br /><searchLink fieldCode="AR" term="%22Nishida%2C+Nao%22">Nishida, Nao</searchLink><br /><searchLink fieldCode="AR" term="%22Sugiyama%2C+Masaya%22">Sugiyama, Masaya</searchLink><br /><searchLink fieldCode="AR" term="%22Kawai%2C+Yosuke%22">Kawai, Yosuke</searchLink><br /><searchLink fieldCode="AR" term="%22Posuwan%2C+Nawarat%22">Posuwan, Nawarat</searchLink><br /><searchLink fieldCode="AR" term="%22Tangkijvanich%2C+Pisit%22">Tangkijvanich, Pisit</searchLink><br /><searchLink fieldCode="AR" term="%22Komolmit%2C+Piyawat%22">Komolmit, Piyawat</searchLink><br /><searchLink fieldCode="AR" term="%22Tsuiji%2C+Makoto%22">Tsuiji, Makoto</searchLink><br /><searchLink fieldCode="AR" term="%22Shotelersuk%2C+Vorasuk%22">Shotelersuk, Vorasuk</searchLink><br /><searchLink fieldCode="AR" term="%22Poovorawan%2C+Yong%22">Poovorawan, Yong</searchLink><br /><searchLink fieldCode="AR" term="%22Mizokami%2C+Masashi%22">Mizokami, Masashi</searchLink><br /><searchLink fieldCode="AR" term="%22Tokunaga%2C+Katsushi%22">Tokunaga, Katsushi</searchLink>
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  Data: Frontiers in Genetics; 6/13/2022, Vol. 13, p1-10, 10p
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22CHRONIC+hepatitis+B%22">CHRONIC hepatitis B</searchLink><br /><searchLink fieldCode="DE" term="%22GENOME-wide+association+studies%22">GENOME-wide association studies</searchLink><br /><searchLink fieldCode="DE" term="%22GENETIC+variation%22">GENETIC variation</searchLink><br /><searchLink fieldCode="DE" term="%22SINGLE+nucleotide+polymorphisms%22">SINGLE nucleotide polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22HEPATITIS+B+virus%22">HEPATITIS B virus</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: To identify novel host genetic variants that predispose to hepatitis B virus (HBV) persistence, we performed the first genome-wide association study in the Thai population involving 318 cases of chronic hepatitis B and 309 healthy controls after quality control measures. We detected the genome-wide significant association of the HLA class II region (HLA-DPA1/DPB1 , rs7770370, p -value = 7.71 × 10<superscript>−10</superscript>, OR = 0.49) with HBV chronicity. Subsequent HLA allele imputation revealed HLA-DPA1*01:03 (Pc = 1.21 × 10<superscript>−6</superscript>, OR = 0.53), HLA-DPB1*02:01 (Pc = 2.17 × 10<superscript>−3</superscript>, OR = 0.50), and HLA-DQB1*06:09 (Pc = 2.17 × 10<superscript>−2</superscript>, OR = 0.07) as protective alleles, and HLA-DPA1*02:02 (Pc = 6.32 × 10<superscript>−5</superscript>, OR = 1.63), HLA-DPB1*05:01 (Pc = 1.13 × 10<superscript>−4</superscript>, OR = 1.72), HLA-DPB1*13:01 (Pc = 4.68 × 10<superscript>−2</superscript>, OR = 1.60), and HLA-DQB1*03:03 (Pc = 1.11 × 10<superscript>−3</superscript>, OR = 1.84) as risk alleles for HBV persistence. We also detected suggestive associations in the PLSCR1 (rs35766154), PDLIM5 (rs62321986), SGPL1 (rs144998273), and MGST1 (rs1828682) loci. Among single-nucleotide polymorphisms in the PLSCR1 locus, rs1061307 was identified as the primary functional variant by in silico/in vitro functional analysis. In addition to replicating the association of the HLA class II region, we detected novel candidate loci that provide new insights into the pathophysiology of chronic hepatitis B. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Frontiers in Genetics is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3389/fgene.2022.887121
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      – Code: eng
        Text: English
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        PageCount: 10
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    Subjects:
      – SubjectFull: CHRONIC hepatitis B
        Type: general
      – SubjectFull: GENOME-wide association studies
        Type: general
      – SubjectFull: GENETIC variation
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      – SubjectFull: SINGLE nucleotide polymorphisms
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      – SubjectFull: HEPATITIS B virus
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              Text: 6/13/2022
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