Electrospun Biomimetic Multifunctional Nanofibers Loaded with Ferulic Acid for Enhanced Antimicrobial and Wound-Healing Activities in STZ-Induced Diabetic Rats.
| Title: | Electrospun Biomimetic Multifunctional Nanofibers Loaded with Ferulic Acid for Enhanced Antimicrobial and Wound-Healing Activities in STZ-Induced Diabetic Rats. |
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| Authors: | Anand, Sneha, Pandey, Prashant, Begum, Mohammed Yasmin, Chidambaram, Kumarappan, Arya, Dilip Kumar, Gupta, Ravi Kr., Sankhwar, Ruchi, Jaiswal, Shweta, Thakur, Sunita, Rajinikanth, Paruvathanahalli Siddalingam |
| Source: | Pharmaceuticals (14248247); Mar2022, Vol. 15 Issue 3, p302, 22p |
| Subject Terms: | NANOFIBERS, CELLULOSE acetate, FERULIC acid, DIABETIC foot, ANTI-infective agents, DIABETES complications, SCANNING electron microscopy |
| Abstract: | Diabetic foot ulceration is the most distressing complication of diabetes having no standard therapy. Nanofibers are an emerging and versatile nanotechnology-based drug-delivery system with unique wound-healing properties. This study aimed to prepare and evaluate silk-sericin based hybrid nanofibrous mats for diabetic foot ulcer. The nanofibrous mats were prepared by electrospinning using silk sericin mixed with different proportions of polycaprolactone (PCL) and cellulose acetate (CA) loaded with ferulic acid (FA). The in vitro characterizations, such as surface morphology, mechanical properties, swelling behavior, biodegradability, scanning electron microscopy, and drug release were carried out. The SEM images indicated that nanofibers formed with varied diameters, ranging from 100 to 250 nm, and their tensile strength was found to range from 7 to 15 MPa. In vitro release demonstrated that the nanofibers sustained FA release over an extended time of period. In vitro cytotoxicity showed that the nanofibers possessed a lower cytotoxicity in HaCaT cells. The in vivo wound-healing studies demonstrated an excellent wound-healing efficiency of the nanofibers in diabetic rats. Furthermore, the histopathological studies showed the nanofibers' ability to restore the skin's normal structure. Therefore, it was concluded that the prepared silk-sericin-based hybrid nanofibers loaded with FA could be a promising drug-delivery platform for the effective treatment of diabetic foot ulcers. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Header | DbId: edb DbLabel: Complementary Index An: 156072685 RelevancyScore: 938 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 937.570434570313 |
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| Items | – Name: Title Label: Title Group: Ti Data: Electrospun Biomimetic Multifunctional Nanofibers Loaded with Ferulic Acid for Enhanced Antimicrobial and Wound-Healing Activities in STZ-Induced Diabetic Rats. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Anand%2C+Sneha%22">Anand, Sneha</searchLink><br /><searchLink fieldCode="AR" term="%22Pandey%2C+Prashant%22">Pandey, Prashant</searchLink><br /><searchLink fieldCode="AR" term="%22Begum%2C+Mohammed+Yasmin%22">Begum, Mohammed Yasmin</searchLink><br /><searchLink fieldCode="AR" term="%22Chidambaram%2C+Kumarappan%22">Chidambaram, Kumarappan</searchLink><br /><searchLink fieldCode="AR" term="%22Arya%2C+Dilip+Kumar%22">Arya, Dilip Kumar</searchLink><br /><searchLink fieldCode="AR" term="%22Gupta%2C+Ravi+Kr%2E%22">Gupta, Ravi Kr.</searchLink><br /><searchLink fieldCode="AR" term="%22Sankhwar%2C+Ruchi%22">Sankhwar, Ruchi</searchLink><br /><searchLink fieldCode="AR" term="%22Jaiswal%2C+Shweta%22">Jaiswal, Shweta</searchLink><br /><searchLink fieldCode="AR" term="%22Thakur%2C+Sunita%22">Thakur, Sunita</searchLink><br /><searchLink fieldCode="AR" term="%22Rajinikanth%2C+Paruvathanahalli+Siddalingam%22">Rajinikanth, Paruvathanahalli Siddalingam</searchLink> – Name: TitleSource Label: Source Group: Src Data: Pharmaceuticals (14248247); Mar2022, Vol. 15 Issue 3, p302, 22p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22NANOFIBERS%22">NANOFIBERS</searchLink><br /><searchLink fieldCode="DE" term="%22CELLULOSE+acetate%22">CELLULOSE acetate</searchLink><br /><searchLink fieldCode="DE" term="%22FERULIC+acid%22">FERULIC acid</searchLink><br /><searchLink fieldCode="DE" term="%22DIABETIC+foot%22">DIABETIC foot</searchLink><br /><searchLink fieldCode="DE" term="%22ANTI-infective+agents%22">ANTI-infective agents</searchLink><br /><searchLink fieldCode="DE" term="%22DIABETES+complications%22">DIABETES complications</searchLink><br /><searchLink fieldCode="DE" term="%22SCANNING+electron+microscopy%22">SCANNING electron microscopy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Diabetic foot ulceration is the most distressing complication of diabetes having no standard therapy. Nanofibers are an emerging and versatile nanotechnology-based drug-delivery system with unique wound-healing properties. This study aimed to prepare and evaluate silk-sericin based hybrid nanofibrous mats for diabetic foot ulcer. The nanofibrous mats were prepared by electrospinning using silk sericin mixed with different proportions of polycaprolactone (PCL) and cellulose acetate (CA) loaded with ferulic acid (FA). The in vitro characterizations, such as surface morphology, mechanical properties, swelling behavior, biodegradability, scanning electron microscopy, and drug release were carried out. The SEM images indicated that nanofibers formed with varied diameters, ranging from 100 to 250 nm, and their tensile strength was found to range from 7 to 15 MPa. In vitro release demonstrated that the nanofibers sustained FA release over an extended time of period. In vitro cytotoxicity showed that the nanofibers possessed a lower cytotoxicity in HaCaT cells. The in vivo wound-healing studies demonstrated an excellent wound-healing efficiency of the nanofibers in diabetic rats. Furthermore, the histopathological studies showed the nanofibers' ability to restore the skin's normal structure. Therefore, it was concluded that the prepared silk-sericin-based hybrid nanofibers loaded with FA could be a promising drug-delivery platform for the effective treatment of diabetic foot ulcers. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Pharmaceuticals (14248247) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/ph15030302 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 22 StartPage: 302 Subjects: – SubjectFull: NANOFIBERS Type: general – SubjectFull: CELLULOSE acetate Type: general – SubjectFull: FERULIC acid Type: general – SubjectFull: DIABETIC foot Type: general – SubjectFull: ANTI-infective agents Type: general – SubjectFull: DIABETES complications Type: general – SubjectFull: SCANNING electron microscopy Type: general Titles: – TitleFull: Electrospun Biomimetic Multifunctional Nanofibers Loaded with Ferulic Acid for Enhanced Antimicrobial and Wound-Healing Activities in STZ-Induced Diabetic Rats. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Anand, Sneha – PersonEntity: Name: NameFull: Pandey, Prashant – PersonEntity: Name: NameFull: Begum, Mohammed Yasmin – PersonEntity: Name: NameFull: Chidambaram, Kumarappan – PersonEntity: Name: NameFull: Arya, Dilip Kumar – PersonEntity: Name: NameFull: Gupta, Ravi Kr. – PersonEntity: Name: NameFull: Sankhwar, Ruchi – PersonEntity: Name: NameFull: Jaiswal, Shweta – PersonEntity: Name: NameFull: Thakur, Sunita – PersonEntity: Name: NameFull: Rajinikanth, Paruvathanahalli Siddalingam IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 14248247 Numbering: – Type: volume Value: 15 – Type: issue Value: 3 Titles: – TitleFull: Pharmaceuticals (14248247) Type: main |
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