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Adjuvant Photodynamic Therapy, Mediated via Topical Versus Systemic Administration of 5‐Aminolevulinic Acid for Control of Murine Mammary Tumor after Surgical Resection†.

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Title: Adjuvant Photodynamic Therapy, Mediated via Topical Versus Systemic Administration of 5‐Aminolevulinic Acid for Control of Murine Mammary Tumor after Surgical Resection†.
Authors: Carter, Shirron, Miller, Joann, Cramer, Gwendolyn, Yuan, Min, Guzman, Stacy, Putt, Mary E., Cengel, Keith A., Freedman, Gary M., Busch, Theresa M.
Source: Photochemistry & Photobiology; Jan/Feb2022, Vol. 98 Issue 1, p117-126, 10p
Subject Terms: PHOTODYNAMIC therapy, ALPHA-linolenic acid, BREAST cancer, LUMPECTOMY, TUMORS, CANCER treatment, CALRETININ
Abstract: Treatment de‐escalation is sought in the management of precursor lesions of early stage breast cancer, driving the appeal of adjuvant modalities to lumpectomy that reduce toxicity and minimally detract from patient quality of life. We investigate photodynamic therapy (PDT), with the photosensitizing prodrug, 5‐aminolevulinic acid (ALA), as adjuvant therapy to complete resection of murine mammary tumor (propagated from TUBO cells). ALA was delivered either systemically (oral, 250 mg kg−1) at 5 h before 632 nm illumination or topically (20% solution) to the resection site at 10 min before light delivery to 135 J cm−2. Treatment with either oral‐ALA‐PDT (oALA‐PDT) or topical‐ALA‐PDT (tALA‐PDT) to the mammary fat pad after TUBO complete resection (CR) produced long‐term tumor control with 90‐day complete response rates of 21% and 32%, respectively, compared to control rates of 0–5% in mice receiving only CR. Thus, CR/tALA‐PDT was equipotent to CR/oALA‐PDT despite ~10‐fold lower levels of ALA‐induced protoporphyrin XI as photosensitizer after topical versus oral‐ALA administration. CR/oALA‐PDT produced more vascular damage, greater proportion of tissue‐resident neutrophils and stronger inflammation when compared to CR/tALA‐PDT. Collectively, these data provide rationale for ongoing investigation of ALA‐PDT as adjuvant therapy after lumpectomy for increased probability of local control in the treatment of breast cancer. [ABSTRACT FROM AUTHOR]
Copyright of Photochemistry & Photobiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Adjuvant Photodynamic Therapy, Mediated via Topical Versus Systemic Administration of 5‐Aminolevulinic Acid for Control of Murine Mammary Tumor after Surgical Resection<superscript>†</superscript>.
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  Data: <searchLink fieldCode="AR" term="%22Carter%2C+Shirron%22">Carter, Shirron</searchLink><br /><searchLink fieldCode="AR" term="%22Miller%2C+Joann%22">Miller, Joann</searchLink><br /><searchLink fieldCode="AR" term="%22Cramer%2C+Gwendolyn%22">Cramer, Gwendolyn</searchLink><br /><searchLink fieldCode="AR" term="%22Yuan%2C+Min%22">Yuan, Min</searchLink><br /><searchLink fieldCode="AR" term="%22Guzman%2C+Stacy%22">Guzman, Stacy</searchLink><br /><searchLink fieldCode="AR" term="%22Putt%2C+Mary+E%2E%22">Putt, Mary E.</searchLink><br /><searchLink fieldCode="AR" term="%22Cengel%2C+Keith+A%2E%22">Cengel, Keith A.</searchLink><br /><searchLink fieldCode="AR" term="%22Freedman%2C+Gary+M%2E%22">Freedman, Gary M.</searchLink><br /><searchLink fieldCode="AR" term="%22Busch%2C+Theresa+M%2E%22">Busch, Theresa M.</searchLink>
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  Data: Photochemistry & Photobiology; Jan/Feb2022, Vol. 98 Issue 1, p117-126, 10p
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  Data: <searchLink fieldCode="DE" term="%22PHOTODYNAMIC+therapy%22">PHOTODYNAMIC therapy</searchLink><br /><searchLink fieldCode="DE" term="%22ALPHA-linolenic+acid%22">ALPHA-linolenic acid</searchLink><br /><searchLink fieldCode="DE" term="%22BREAST+cancer%22">BREAST cancer</searchLink><br /><searchLink fieldCode="DE" term="%22LUMPECTOMY%22">LUMPECTOMY</searchLink><br /><searchLink fieldCode="DE" term="%22TUMORS%22">TUMORS</searchLink><br /><searchLink fieldCode="DE" term="%22CANCER+treatment%22">CANCER treatment</searchLink><br /><searchLink fieldCode="DE" term="%22CALRETININ%22">CALRETININ</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Treatment de‐escalation is sought in the management of precursor lesions of early stage breast cancer, driving the appeal of adjuvant modalities to lumpectomy that reduce toxicity and minimally detract from patient quality of life. We investigate photodynamic therapy (PDT), with the photosensitizing prodrug, 5‐aminolevulinic acid (ALA), as adjuvant therapy to complete resection of murine mammary tumor (propagated from TUBO cells). ALA was delivered either systemically (oral, 250 mg kg−1) at 5 h before 632 nm illumination or topically (20% solution) to the resection site at 10 min before light delivery to 135 J cm−2. Treatment with either oral‐ALA‐PDT (oALA‐PDT) or topical‐ALA‐PDT (tALA‐PDT) to the mammary fat pad after TUBO complete resection (CR) produced long‐term tumor control with 90‐day complete response rates of 21% and 32%, respectively, compared to control rates of 0–5% in mice receiving only CR. Thus, CR/tALA‐PDT was equipotent to CR/oALA‐PDT despite ~10‐fold lower levels of ALA‐induced protoporphyrin XI as photosensitizer after topical versus oral‐ALA administration. CR/oALA‐PDT produced more vascular damage, greater proportion of tissue‐resident neutrophils and stronger inflammation when compared to CR/tALA‐PDT. Collectively, these data provide rationale for ongoing investigation of ALA‐PDT as adjuvant therapy after lumpectomy for increased probability of local control in the treatment of breast cancer. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Photochemistry & Photobiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1111/php.13482
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      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 117
    Subjects:
      – SubjectFull: PHOTODYNAMIC therapy
        Type: general
      – SubjectFull: ALPHA-linolenic acid
        Type: general
      – SubjectFull: BREAST cancer
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      – SubjectFull: LUMPECTOMY
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      – SubjectFull: CANCER treatment
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      – SubjectFull: CALRETININ
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      – TitleFull: Adjuvant Photodynamic Therapy, Mediated via Topical Versus Systemic Administration of 5‐Aminolevulinic Acid for Control of Murine Mammary Tumor after Surgical Resection†.
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            – D: 01
              M: 01
              Text: Jan/Feb2022
              Type: published
              Y: 2022
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