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Prognostic Impact of Baseline Immunologic Profile in Aggressive B-cell non-Hodgkin's Lymphomas.

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Title: Prognostic Impact of Baseline Immunologic Profile in Aggressive B-cell non-Hodgkin's Lymphomas.
Authors: Ramadan, Safaa, Ceparano, Giusy, Cignetti, Alessandro, Sammassimo, Simona, Bagnardi, Vincenzo, Pagan, Eleonora, Gottardi, Daniela, Fiori, Stefano, Passerini, Rita, Radice, Tommaso, Saglio, Giuseppe, Tarella, Corrado
Source: Mediterranean Journal of Hematology & Infectious Diseases; 2021, Vol. 13 Issue 1, p1-5, 5p
Subject Terms: MONOCYTE lymphocyte ratio, LYMPHOMAS, NON-Hodgkin's lymphoma, IMMUNOGLOBULINS
Abstract: Host immune homeostasis as an independent prognostic indicator has been inadequately evaluated in aggressive non-Hodgkin's lymphomas (NHL). The present study addresses the prognostic significance in aggressive NHLs of the immunologic profile evaluated by pretreatment serum levels of immunoglobulins (Ig) and lymphocyte-monocyte ratio (LMR). In this series of 90 patients with aggressive lymphoma, the median level for IgG was 1,024mg/dl (range 436-2236), and for LMR was 2.2 (range 0.2-13.8). CR rate was higher with IgG levels =1,024mg/dL (91% vs 77% p=0.059). LMR = 2.2 was associated with lower 1-year PFS (73% vs. 92%, p 0.016). Patients with good/very good R-IPI showed a reduced PFS if IgG or LMR was low, while patients with poor R-IPI did better if LMR or IgG levels were high. We combined both parameters with the RIPI and produced a four-risk prognostic score showing one-year PFS of 95% (95% CI 68%-99%), 100% (95% CI 100%-100%), 73% (95% CI 52%-86%), and 59% (95% CI 31%-79%), in patients with zero, one, two and three risk factors, respectively. The results indicate for the first time the value of baseline serum Ig levels in the prognostic assessment of aggressive lymphoma. [ABSTRACT FROM AUTHOR]
Copyright of Mediterranean Journal of Hematology & Infectious Diseases is the property of PAGEPress and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Prognostic Impact of Baseline Immunologic Profile in Aggressive B-cell non-Hodgkin's Lymphomas.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Ramadan%2C+Safaa%22">Ramadan, Safaa</searchLink><br /><searchLink fieldCode="AR" term="%22Ceparano%2C+Giusy%22">Ceparano, Giusy</searchLink><br /><searchLink fieldCode="AR" term="%22Cignetti%2C+Alessandro%22">Cignetti, Alessandro</searchLink><br /><searchLink fieldCode="AR" term="%22Sammassimo%2C+Simona%22">Sammassimo, Simona</searchLink><br /><searchLink fieldCode="AR" term="%22Bagnardi%2C+Vincenzo%22">Bagnardi, Vincenzo</searchLink><br /><searchLink fieldCode="AR" term="%22Pagan%2C+Eleonora%22">Pagan, Eleonora</searchLink><br /><searchLink fieldCode="AR" term="%22Gottardi%2C+Daniela%22">Gottardi, Daniela</searchLink><br /><searchLink fieldCode="AR" term="%22Fiori%2C+Stefano%22">Fiori, Stefano</searchLink><br /><searchLink fieldCode="AR" term="%22Passerini%2C+Rita%22">Passerini, Rita</searchLink><br /><searchLink fieldCode="AR" term="%22Radice%2C+Tommaso%22">Radice, Tommaso</searchLink><br /><searchLink fieldCode="AR" term="%22Saglio%2C+Giuseppe%22">Saglio, Giuseppe</searchLink><br /><searchLink fieldCode="AR" term="%22Tarella%2C+Corrado%22">Tarella, Corrado</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Mediterranean Journal of Hematology & Infectious Diseases; 2021, Vol. 13 Issue 1, p1-5, 5p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22MONOCYTE+lymphocyte+ratio%22">MONOCYTE lymphocyte ratio</searchLink><br /><searchLink fieldCode="DE" term="%22LYMPHOMAS%22">LYMPHOMAS</searchLink><br /><searchLink fieldCode="DE" term="%22NON-Hodgkin's+lymphoma%22">NON-Hodgkin's lymphoma</searchLink><br /><searchLink fieldCode="DE" term="%22IMMUNOGLOBULINS%22">IMMUNOGLOBULINS</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Host immune homeostasis as an independent prognostic indicator has been inadequately evaluated in aggressive non-Hodgkin's lymphomas (NHL). The present study addresses the prognostic significance in aggressive NHLs of the immunologic profile evaluated by pretreatment serum levels of immunoglobulins (Ig) and lymphocyte-monocyte ratio (LMR). In this series of 90 patients with aggressive lymphoma, the median level for IgG was 1,024mg/dl (range 436-2236), and for LMR was 2.2 (range 0.2-13.8). CR rate was higher with IgG levels =1,024mg/dL (91% vs 77% p=0.059). LMR = 2.2 was associated with lower 1-year PFS (73% vs. 92%, p 0.016). Patients with good/very good R-IPI showed a reduced PFS if IgG or LMR was low, while patients with poor R-IPI did better if LMR or IgG levels were high. We combined both parameters with the RIPI and produced a four-risk prognostic score showing one-year PFS of 95% (95% CI 68%-99%), 100% (95% CI 100%-100%), 73% (95% CI 52%-86%), and 59% (95% CI 31%-79%), in patients with zero, one, two and three risk factors, respectively. The results indicate for the first time the value of baseline serum Ig levels in the prognostic assessment of aggressive lymphoma. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Mediterranean Journal of Hematology & Infectious Diseases is the property of PAGEPress and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.4084/MJHID.2021.018
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      – Code: eng
        Text: English
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      – SubjectFull: MONOCYTE lymphocyte ratio
        Type: general
      – SubjectFull: LYMPHOMAS
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      – SubjectFull: NON-Hodgkin's lymphoma
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      – SubjectFull: IMMUNOGLOBULINS
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              Text: 2021
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