Central nervous system ALK-negative anaplastic large cell lymphoma with IRF4/DUSP22 rearrangement.
| Title: | Central nervous system ALK-negative anaplastic large cell lymphoma with IRF4/DUSP22 rearrangement. |
|---|---|
| Authors: | Magaki, Shino, Satyadev, Radha, Chen, Zesheng, Yung, Kathryn S., Vinters, Harry V., Kinney, Marsha C., Said, Jonathan W. |
| Source: | Brain Tumor Pathology; Jan2022, Vol. 39 Issue 1, p25-34, 10p |
| Abstract: | Anaplastic large cell lymphomas (ALCL) are mature T-cell neoplasms, approximately half of which harbor rearrangements of the ALK gene that confer a good prognosis. Recent studies have demonstrated that a significant proportion of ALK-negative ALCLs demonstrate rearrangements of the IRF4/DUSP22 locus that also are typically associated with a favorable prognosis. ALCL with primary involvement of the central nervous system (CNS) is extremely rare. We report what may be the first case of ALK-negative ALCL with IRF4/DUSP22 rearrangement involving the brain in a 55-year-old man. Magnetic resonance imaging demonstrated signal abnormalities in the periventricular region, corpus callosum and cingulate gyrus. Biopsy revealed a diffuse parenchymal and angiocentric infiltrate of CD30-positive cells that showed IRF4/DUSP22 rearrangement by fluorescence in situ hybridization. We also review the clinical and pathologic features of primary CNS ALK-negative ALCLs in the literature and highlight the need for awareness of this entity to optimize appropriate management. [ABSTRACT FROM AUTHOR] |
| Copyright of Brain Tumor Pathology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Complementary Index |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edb&genre=article&issn=14337398&ISBN=&volume=39&issue=1&date=20220101&spage=25&pages=25-34&title=Brain Tumor Pathology&atitle=Central%20nervous%20system%20ALK-negative%20anaplastic%20large%20cell%20lymphoma%20with%20IRF4%2FDUSP22%20rearrangement.&aulast=Magaki%2C%20Shino&id=DOI:10.1007/s10014-021-00415-0 Name: Full Text Finder (for New FTF UI) (s8985755) Category: fullText Text: Find It @ SCU Libraries MouseOverText: Find It @ SCU Libraries |
|---|---|
| Header | DbId: edb DbLabel: Complementary Index An: 154611729 RelevancyScore: 932 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 931.6591796875 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Central nervous system ALK-negative anaplastic large cell lymphoma with IRF4/DUSP22 rearrangement. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Magaki%2C+Shino%22">Magaki, Shino</searchLink><br /><searchLink fieldCode="AR" term="%22Satyadev%2C+Radha%22">Satyadev, Radha</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Zesheng%22">Chen, Zesheng</searchLink><br /><searchLink fieldCode="AR" term="%22Yung%2C+Kathryn+S%2E%22">Yung, Kathryn S.</searchLink><br /><searchLink fieldCode="AR" term="%22Vinters%2C+Harry+V%2E%22">Vinters, Harry V.</searchLink><br /><searchLink fieldCode="AR" term="%22Kinney%2C+Marsha+C%2E%22">Kinney, Marsha C.</searchLink><br /><searchLink fieldCode="AR" term="%22Said%2C+Jonathan+W%2E%22">Said, Jonathan W.</searchLink> – Name: TitleSource Label: Source Group: Src Data: Brain Tumor Pathology; Jan2022, Vol. 39 Issue 1, p25-34, 10p – Name: Abstract Label: Abstract Group: Ab Data: Anaplastic large cell lymphomas (ALCL) are mature T-cell neoplasms, approximately half of which harbor rearrangements of the ALK gene that confer a good prognosis. Recent studies have demonstrated that a significant proportion of ALK-negative ALCLs demonstrate rearrangements of the IRF4/DUSP22 locus that also are typically associated with a favorable prognosis. ALCL with primary involvement of the central nervous system (CNS) is extremely rare. We report what may be the first case of ALK-negative ALCL with IRF4/DUSP22 rearrangement involving the brain in a 55-year-old man. Magnetic resonance imaging demonstrated signal abnormalities in the periventricular region, corpus callosum and cingulate gyrus. Biopsy revealed a diffuse parenchymal and angiocentric infiltrate of CD30-positive cells that showed IRF4/DUSP22 rearrangement by fluorescence in situ hybridization. We also review the clinical and pathologic features of primary CNS ALK-negative ALCLs in the literature and highlight the need for awareness of this entity to optimize appropriate management. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Brain Tumor Pathology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=154611729 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10014-021-00415-0 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 25 Titles: – TitleFull: Central nervous system ALK-negative anaplastic large cell lymphoma with IRF4/DUSP22 rearrangement. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Magaki, Shino – PersonEntity: Name: NameFull: Satyadev, Radha – PersonEntity: Name: NameFull: Chen, Zesheng – PersonEntity: Name: NameFull: Yung, Kathryn S. – PersonEntity: Name: NameFull: Vinters, Harry V. – PersonEntity: Name: NameFull: Kinney, Marsha C. – PersonEntity: Name: NameFull: Said, Jonathan W. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 14337398 Numbering: – Type: volume Value: 39 – Type: issue Value: 1 Titles: – TitleFull: Brain Tumor Pathology Type: main |
| ResultId | 1 |