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Differentially Expressed lncRNAs Related to the Development of Abdominal Fat in Gushi Chickens and Their Interaction Regulatory Network.

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Title: Differentially Expressed lncRNAs Related to the Development of Abdominal Fat in Gushi Chickens and Their Interaction Regulatory Network.
Authors: Zhai, Bin, Zhao, Yinli, Fan, Shengxin, Yuan, Pengtao, Li, Hongtai, Li, Shuaihao, Li, Yuanfang, Zhang, Yanhua, Huang, Hetian, Li, Hong, Kang, Xiangtao, Li, Guoxi
Source: Frontiers in Genetics; 12/24/2021, Vol. 12, p1-12, 12p
Subject Terms: ABDOMINAL adipose tissue, LINCRNA, RNA metabolism, GENETIC regulation, CHICKENS, METABOLIC regulation, CELLULAR control mechanisms
Abstract: Chickens are one of the most important sources of meat worldwide, and the growth status of abdominal fat is closely related to production efficiency. Long noncoding RNAs (lncRNAs) play an important role in lipid metabolism and deposition regulation. However, research on the expression profile of lncRNAs related to the development of abdominal fat in chickens after hatching and their interaction regulatory networks is still lacking. To characterize the lncRNA expression profile during the development of chicken abdominal fat, abdominal adipose tissues from 6-, 14-, 22-, and 30-week-old Chinese Gushi chickens were herein used to construct 12 cDNA libraries, and a total of 3,827 new lncRNAs and 5,466 previously annotated lncRNAs were revealed. At the same time, based on the comparative analysis of five combinations, 276 differentially expressed lncRNAs (DE-lncRNAs) were screened. Functional enrichment analysis showed that the predicted target genes of these DE-lncRNAs were significantly enriched in pathways related to the posttranscriptional regulation of gene expression, negative regulation of cell proliferation, cell adhesion and other biological processes, glycosphingolipid biosynthesis, PPAR signaling, fatty acid degradation, fatty acid synthesis and others. In addition, association analysis of the lncRNA transcriptome profile was performed, and DE-lncRNA-related lncRNA-mRNA, lncRNA-miRNA and lncRNA-miRNA-mRNA interaction regulatory networks were constructed. The results showed that DE-lncRNA formed a complex network with PPAR pathway components, including PPARD , ACOX1 , ADIPOQ , CPT1A , FABP5 , ASBG2 , LPL , PLIN2 and related miRNAs, including mir-200b-3p, mir-130b-3p, mir-215-5p, mir-122-5p, mir-223 and mir-125b-5p, and played an important regulatory role in biological processes such as lipid metabolism, adipocyte proliferation and differentiation. This study described the dynamic expression profile of lncRNAs in the abdominal fat of Gushi chickens for the first time and constructed the DE-lncRNA interaction regulatory network. The results expand the number of known lncRNAs in chicken abdominal fat and provide valuable resources for further elucidating the posttranscriptional regulatory mechanism of chicken abdominal fat development or deposition. [ABSTRACT FROM AUTHOR]
Copyright of Frontiers in Genetics is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Differentially Expressed lncRNAs Related to the Development of Abdominal Fat in Gushi Chickens and Their Interaction Regulatory Network.
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  Data: <searchLink fieldCode="AR" term="%22Zhai%2C+Bin%22">Zhai, Bin</searchLink><br /><searchLink fieldCode="AR" term="%22Zhao%2C+Yinli%22">Zhao, Yinli</searchLink><br /><searchLink fieldCode="AR" term="%22Fan%2C+Shengxin%22">Fan, Shengxin</searchLink><br /><searchLink fieldCode="AR" term="%22Yuan%2C+Pengtao%22">Yuan, Pengtao</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Hongtai%22">Li, Hongtai</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Shuaihao%22">Li, Shuaihao</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Yuanfang%22">Li, Yuanfang</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Yanhua%22">Zhang, Yanhua</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+Hetian%22">Huang, Hetian</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Hong%22">Li, Hong</searchLink><br /><searchLink fieldCode="AR" term="%22Kang%2C+Xiangtao%22">Kang, Xiangtao</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Guoxi%22">Li, Guoxi</searchLink>
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  Data: Frontiers in Genetics; 12/24/2021, Vol. 12, p1-12, 12p
– Name: Subject
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  Group: Su
  Data: <searchLink fieldCode="DE" term="%22ABDOMINAL+adipose+tissue%22">ABDOMINAL adipose tissue</searchLink><br /><searchLink fieldCode="DE" term="%22LINCRNA%22">LINCRNA</searchLink><br /><searchLink fieldCode="DE" term="%22RNA+metabolism%22">RNA metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22GENETIC+regulation%22">GENETIC regulation</searchLink><br /><searchLink fieldCode="DE" term="%22CHICKENS%22">CHICKENS</searchLink><br /><searchLink fieldCode="DE" term="%22METABOLIC+regulation%22">METABOLIC regulation</searchLink><br /><searchLink fieldCode="DE" term="%22CELLULAR+control+mechanisms%22">CELLULAR control mechanisms</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Chickens are one of the most important sources of meat worldwide, and the growth status of abdominal fat is closely related to production efficiency. Long noncoding RNAs (lncRNAs) play an important role in lipid metabolism and deposition regulation. However, research on the expression profile of lncRNAs related to the development of abdominal fat in chickens after hatching and their interaction regulatory networks is still lacking. To characterize the lncRNA expression profile during the development of chicken abdominal fat, abdominal adipose tissues from 6-, 14-, 22-, and 30-week-old Chinese Gushi chickens were herein used to construct 12 cDNA libraries, and a total of 3,827 new lncRNAs and 5,466 previously annotated lncRNAs were revealed. At the same time, based on the comparative analysis of five combinations, 276 differentially expressed lncRNAs (DE-lncRNAs) were screened. Functional enrichment analysis showed that the predicted target genes of these DE-lncRNAs were significantly enriched in pathways related to the posttranscriptional regulation of gene expression, negative regulation of cell proliferation, cell adhesion and other biological processes, glycosphingolipid biosynthesis, PPAR signaling, fatty acid degradation, fatty acid synthesis and others. In addition, association analysis of the lncRNA transcriptome profile was performed, and DE-lncRNA-related lncRNA-mRNA, lncRNA-miRNA and lncRNA-miRNA-mRNA interaction regulatory networks were constructed. The results showed that DE-lncRNA formed a complex network with PPAR pathway components, including PPARD , ACOX1 , ADIPOQ , CPT1A , FABP5 , ASBG2 , LPL , PLIN2 and related miRNAs, including mir-200b-3p, mir-130b-3p, mir-215-5p, mir-122-5p, mir-223 and mir-125b-5p, and played an important regulatory role in biological processes such as lipid metabolism, adipocyte proliferation and differentiation. This study described the dynamic expression profile of lncRNAs in the abdominal fat of Gushi chickens for the first time and constructed the DE-lncRNA interaction regulatory network. The results expand the number of known lncRNAs in chicken abdominal fat and provide valuable resources for further elucidating the posttranscriptional regulatory mechanism of chicken abdominal fat development or deposition. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Frontiers in Genetics is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3389/fgene.2021.802857
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      – Code: eng
        Text: English
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      – SubjectFull: ABDOMINAL adipose tissue
        Type: general
      – SubjectFull: LINCRNA
        Type: general
      – SubjectFull: RNA metabolism
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      – SubjectFull: GENETIC regulation
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      – SubjectFull: CHICKENS
        Type: general
      – SubjectFull: METABOLIC regulation
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      – SubjectFull: CELLULAR control mechanisms
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              Text: 12/24/2021
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              Y: 2021
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