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Mitochondrial-derived peptides in aging and age-related diseases.

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Title: Mitochondrial-derived peptides in aging and age-related diseases.
Authors: Kim, Su-Jeong, Miller, Brendan, Kumagai, Hiroshi, Silverstein, Ana R., Flores, Melanie, Yen, Kelvin
Source: GeroScience; Jun2021, Vol. 43 Issue 3, p1113-1121, 9p
Subject Terms: CELLULAR aging, AGE factors in disease, PEPTIDES, GENETIC variation
Abstract: A decline in mitochondrial quality and activity has been associated with normal aging and correlated with the development of a wide range of age-related diseases. Here, we review the evidence that a decline in the levels of mitochondrial-derived peptides contributes to aging and age-related diseases. In particular, we discuss how mitochondrial-derived peptides, humanin and MOTS-c, contribute to specific aspects of the aging process, including cellular senescence, chronic inflammation, and cognitive decline. Genetic variations in the coding region of humanin and MOTS-c that are associated with age-related diseases are also reviewed, with particular emphasis placed on how mitochondrial variants might, in turn, regulate MDP expression and age-related phenotypes. Taken together, these observations suggest that mitochondrial-derived peptides influence or regulate a number of key aspects of aging and that strategies directed at increasing mitochondrial-derived peptide levels might have broad beneficial effects. [ABSTRACT FROM AUTHOR]
Copyright of GeroScience is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Mitochondrial-derived peptides in aging and age-related diseases.
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  Data: <searchLink fieldCode="AR" term="%22Kim%2C+Su-Jeong%22">Kim, Su-Jeong</searchLink><br /><searchLink fieldCode="AR" term="%22Miller%2C+Brendan%22">Miller, Brendan</searchLink><br /><searchLink fieldCode="AR" term="%22Kumagai%2C+Hiroshi%22">Kumagai, Hiroshi</searchLink><br /><searchLink fieldCode="AR" term="%22Silverstein%2C+Ana+R%2E%22">Silverstein, Ana R.</searchLink><br /><searchLink fieldCode="AR" term="%22Flores%2C+Melanie%22">Flores, Melanie</searchLink><br /><searchLink fieldCode="AR" term="%22Yen%2C+Kelvin%22">Yen, Kelvin</searchLink>
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  Data: GeroScience; Jun2021, Vol. 43 Issue 3, p1113-1121, 9p
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22CELLULAR+aging%22">CELLULAR aging</searchLink><br /><searchLink fieldCode="DE" term="%22AGE+factors+in+disease%22">AGE factors in disease</searchLink><br /><searchLink fieldCode="DE" term="%22PEPTIDES%22">PEPTIDES</searchLink><br /><searchLink fieldCode="DE" term="%22GENETIC+variation%22">GENETIC variation</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: A decline in mitochondrial quality and activity has been associated with normal aging and correlated with the development of a wide range of age-related diseases. Here, we review the evidence that a decline in the levels of mitochondrial-derived peptides contributes to aging and age-related diseases. In particular, we discuss how mitochondrial-derived peptides, humanin and MOTS-c, contribute to specific aspects of the aging process, including cellular senescence, chronic inflammation, and cognitive decline. Genetic variations in the coding region of humanin and MOTS-c that are associated with age-related diseases are also reviewed, with particular emphasis placed on how mitochondrial variants might, in turn, regulate MDP expression and age-related phenotypes. Taken together, these observations suggest that mitochondrial-derived peptides influence or regulate a number of key aspects of aging and that strategies directed at increasing mitochondrial-derived peptide levels might have broad beneficial effects. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of GeroScience is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1007/s11357-020-00262-5
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      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 1113
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      – SubjectFull: CELLULAR aging
        Type: general
      – SubjectFull: AGE factors in disease
        Type: general
      – SubjectFull: PEPTIDES
        Type: general
      – SubjectFull: GENETIC variation
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              Text: Jun2021
              Type: published
              Y: 2021
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              Value: 43
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