Preliminary evidence for an influence of exposure to polycyclic aromatic hydrocarbons on the composition of the gut microbiota and neurodevelopment in three-year-old healthy children.
| Title: | Preliminary evidence for an influence of exposure to polycyclic aromatic hydrocarbons on the composition of the gut microbiota and neurodevelopment in three-year-old healthy children. |
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| Authors: | Zhang, Wei, Sun, Zhongqing, Zhang, Qian, Sun, Zhitao, Su, Ya, Song, Jiahui, Wang, Bingling, Gao, Ruqin |
| Source: | BMC Pediatrics; 2/17/2021, Vol. 21 Issue 1, p1-13, 13p |
| Subject Terms: | POLYCYCLIC aromatic hydrocarbons, GUT microbiome, NEURAL development, CHILD Behavior Checklist, CORD blood |
| Abstract: | |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Preliminary evidence for an influence of exposure to polycyclic aromatic hydrocarbons on the composition of the gut microbiota and neurodevelopment in three-year-old healthy children. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Zhang%2C+Wei%22">Zhang, Wei</searchLink><br /><searchLink fieldCode="AR" term="%22Sun%2C+Zhongqing%22">Sun, Zhongqing</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Qian%22">Zhang, Qian</searchLink><br /><searchLink fieldCode="AR" term="%22Sun%2C+Zhitao%22">Sun, Zhitao</searchLink><br /><searchLink fieldCode="AR" term="%22Su%2C+Ya%22">Su, Ya</searchLink><br /><searchLink fieldCode="AR" term="%22Song%2C+Jiahui%22">Song, Jiahui</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Bingling%22">Wang, Bingling</searchLink><br /><searchLink fieldCode="AR" term="%22Gao%2C+Ruqin%22">Gao, Ruqin</searchLink> – Name: TitleSource Label: Source Group: Src Data: BMC Pediatrics; 2/17/2021, Vol. 21 Issue 1, p1-13, 13p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22POLYCYCLIC+aromatic+hydrocarbons%22">POLYCYCLIC aromatic hydrocarbons</searchLink><br /><searchLink fieldCode="DE" term="%22GUT+microbiome%22">GUT microbiome</searchLink><br /><searchLink fieldCode="DE" term="%22NEURAL+development%22">NEURAL development</searchLink><br /><searchLink fieldCode="DE" term="%22CHILD+Behavior+Checklist%22">CHILD Behavior Checklist</searchLink><br /><searchLink fieldCode="DE" term="%22CORD+blood%22">CORD blood</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: <bold>Background: </bold>During the second and third year after birth the gut microbiota (GM) is subjected to important development. The polycyclic aromatic hydrocarbon (PAH) exposure could influence the GM in animal and early postnatal exposure is associated with neurodevelopment disorder in children. This study was designed to explore the possible influence of the polycyclic aromatic hydrocarbons (PAHs) on the composition of the gut microbiota (GM) and neurodevelopment in a sample of 38 healthy children at the age of 3 years.<bold>Methods: </bold>A brief development (Gesell Development Inventory, GDI) and behavior test (Child Behavior Checklist, CBCL) were completed on 3-yr-olds and stool samples were collected for 16S rRNA V4-V5 sequencing. The PAH-DNA adduct in the umbilical cord blood and the urinary hydroxyl PAHs (OH-PAHs) at the age of 12 months were measured as pre- and postnatal PAH exposure, respectively.<bold>Results: </bold>The most abundant two phyla were Bacteroidetes (68.6%) and Firmicutes (24.2%). The phyla Firmicutes, Actinobacteria, Proteobacteria, Tenericutes, and Lentisphaerae were positively correlated with most domain behaviors of the GDI, whereas the Bacteroidetes, Cyanobacteria, and Fusobacteria were negatively correlated. Correspondingly, the phyla Bacteroidetes, Actinobacteria, and Fusobacteria showed positive correlations with most CBCL core and broadband syndromes, whereas the Firmicutes, Verrucomicrobia, Synergistetes, Proteobacteria and Tenericules were negatively correlated. The OH-PAH levels were not significantly associated with the Firmicutes phylum whereas the Bacteroidetes, Bacteroidia, and Bacteroidales all showed significant negative association with the OH-PAH levels.<bold>Conclusion: </bold>The current findings suggest that composition of the GM is associated with neurodevelopment of the child. PAHs seem to change the relative abundance of some taxa (some deleted and some recruited) to counteract the negative effects of the PAHs. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of BMC Pediatrics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s12887-021-02539-w Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1 Subjects: – SubjectFull: POLYCYCLIC aromatic hydrocarbons Type: general – SubjectFull: GUT microbiome Type: general – SubjectFull: NEURAL development Type: general – SubjectFull: CHILD Behavior Checklist Type: general – SubjectFull: CORD blood Type: general Titles: – TitleFull: Preliminary evidence for an influence of exposure to polycyclic aromatic hydrocarbons on the composition of the gut microbiota and neurodevelopment in three-year-old healthy children. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Zhang, Wei – PersonEntity: Name: NameFull: Sun, Zhongqing – PersonEntity: Name: NameFull: Zhang, Qian – PersonEntity: Name: NameFull: Sun, Zhitao – PersonEntity: Name: NameFull: Su, Ya – PersonEntity: Name: NameFull: Song, Jiahui – PersonEntity: Name: NameFull: Wang, Bingling – PersonEntity: Name: NameFull: Gao, Ruqin IsPartOfRelationships: – BibEntity: Dates: – D: 17 M: 02 Text: 2/17/2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 14712431 Numbering: – Type: volume Value: 21 – Type: issue Value: 1 Titles: – TitleFull: BMC Pediatrics Type: main |
| ResultId | 1 |