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Prospective observational study and serosurvey of SARS-CoV-2 infection in asymptomatic healthcare workers at a Canadian tertiary care center.

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Title: Prospective observational study and serosurvey of SARS-CoV-2 infection in asymptomatic healthcare workers at a Canadian tertiary care center.
Authors: Ferreira, Victor H., Chruscinski, Andrzej, Kulasingam, Vathany, Pugh, Trevor J., Dus, Tamara, Wouters, Brad, Oza, Amit, Ierullo, Matthew, Ku, Terrance, Majchrzak-Kita, Beata, Humar, Sonika T., Bahinskaya, Ilona, Pinzon, Natalia, Zhang, Jianhua, Heisler, Lawrence E., Krzyzanowski, Paul M., Lam, Bernard, Lungu, Ilinca M., Manase, Dorin, Pace, Krista M.
Source: PLoS ONE; 2/16/2021, Vol. 16 Issue 2, p1-11, 11p
Subject Terms: MEDICAL personnel, SARS-CoV-2, TERTIARY care, LONGITUDINAL method, SCIENTIFIC observation, MIDDLE East respiratory syndrome, SEROPREVALENCE
Abstract: Health care workers (HCWs) are at higher risk for SARS-CoV-2 infection and may play a role in transmitting the infection to vulnerable patients and members of the community. This is particularly worrisome in the context of asymptomatic infection. We performed a cross-sectional study looking at asymptomatic SARS-CoV-2 infection in HCWs. We screened asymptomatic HCWs for SARS-CoV-2 via PCR. Complementary viral genome sequencing was performed on positive swab specimens. A seroprevalence analysis was also performed using multiple assays. Asymptomatic health care worker cohorts had a combined swab positivity rate of 29/5776 (0.50%, 95%CI 0.32–0.75) relative to a comparative cohort of symptomatic HCWs, where 54/1597 (3.4%) tested positive for SARS-CoV-2 (ratio of symptomatic to asymptomatic 6.8:1). SARS-CoV-2 seroprevalence among 996 asymptomatic HCWs with no prior known exposure to SARS-CoV-2 was 1.4–3.4%, depending on assay. A novel in-house Coronavirus protein microarray showed differing SARS-CoV-2 protein reactivities and helped define likely true positives vs. suspected false positives. Our study demonstrates the utility of routine screening of asymptomatic HCWs, which may help to identify a significant proportion of infections. [ABSTRACT FROM AUTHOR]
Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Prospective observational study and serosurvey of SARS-CoV-2 infection in asymptomatic healthcare workers at a Canadian tertiary care center.
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  Data: <searchLink fieldCode="AR" term="%22Ferreira%2C+Victor+H%2E%22">Ferreira, Victor H.</searchLink><br /><searchLink fieldCode="AR" term="%22Chruscinski%2C+Andrzej%22">Chruscinski, Andrzej</searchLink><br /><searchLink fieldCode="AR" term="%22Kulasingam%2C+Vathany%22">Kulasingam, Vathany</searchLink><br /><searchLink fieldCode="AR" term="%22Pugh%2C+Trevor+J%2E%22">Pugh, Trevor J.</searchLink><br /><searchLink fieldCode="AR" term="%22Dus%2C+Tamara%22">Dus, Tamara</searchLink><br /><searchLink fieldCode="AR" term="%22Wouters%2C+Brad%22">Wouters, Brad</searchLink><br /><searchLink fieldCode="AR" term="%22Oza%2C+Amit%22">Oza, Amit</searchLink><br /><searchLink fieldCode="AR" term="%22Ierullo%2C+Matthew%22">Ierullo, Matthew</searchLink><br /><searchLink fieldCode="AR" term="%22Ku%2C+Terrance%22">Ku, Terrance</searchLink><br /><searchLink fieldCode="AR" term="%22Majchrzak-Kita%2C+Beata%22">Majchrzak-Kita, Beata</searchLink><br /><searchLink fieldCode="AR" term="%22Humar%2C+Sonika+T%2E%22">Humar, Sonika T.</searchLink><br /><searchLink fieldCode="AR" term="%22Bahinskaya%2C+Ilona%22">Bahinskaya, Ilona</searchLink><br /><searchLink fieldCode="AR" term="%22Pinzon%2C+Natalia%22">Pinzon, Natalia</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jianhua%22">Zhang, Jianhua</searchLink><br /><searchLink fieldCode="AR" term="%22Heisler%2C+Lawrence+E%2E%22">Heisler, Lawrence E.</searchLink><br /><searchLink fieldCode="AR" term="%22Krzyzanowski%2C+Paul+M%2E%22">Krzyzanowski, Paul M.</searchLink><br /><searchLink fieldCode="AR" term="%22Lam%2C+Bernard%22">Lam, Bernard</searchLink><br /><searchLink fieldCode="AR" term="%22Lungu%2C+Ilinca+M%2E%22">Lungu, Ilinca M.</searchLink><br /><searchLink fieldCode="AR" term="%22Manase%2C+Dorin%22">Manase, Dorin</searchLink><br /><searchLink fieldCode="AR" term="%22Pace%2C+Krista+M%2E%22">Pace, Krista M.</searchLink>
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  Data: PLoS ONE; 2/16/2021, Vol. 16 Issue 2, p1-11, 11p
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  Data: <searchLink fieldCode="DE" term="%22MEDICAL+personnel%22">MEDICAL personnel</searchLink><br /><searchLink fieldCode="DE" term="%22SARS-CoV-2%22">SARS-CoV-2</searchLink><br /><searchLink fieldCode="DE" term="%22TERTIARY+care%22">TERTIARY care</searchLink><br /><searchLink fieldCode="DE" term="%22LONGITUDINAL+method%22">LONGITUDINAL method</searchLink><br /><searchLink fieldCode="DE" term="%22SCIENTIFIC+observation%22">SCIENTIFIC observation</searchLink><br /><searchLink fieldCode="DE" term="%22MIDDLE+East+respiratory+syndrome%22">MIDDLE East respiratory syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22SEROPREVALENCE%22">SEROPREVALENCE</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Health care workers (HCWs) are at higher risk for SARS-CoV-2 infection and may play a role in transmitting the infection to vulnerable patients and members of the community. This is particularly worrisome in the context of asymptomatic infection. We performed a cross-sectional study looking at asymptomatic SARS-CoV-2 infection in HCWs. We screened asymptomatic HCWs for SARS-CoV-2 via PCR. Complementary viral genome sequencing was performed on positive swab specimens. A seroprevalence analysis was also performed using multiple assays. Asymptomatic health care worker cohorts had a combined swab positivity rate of 29/5776 (0.50%, 95%CI 0.32–0.75) relative to a comparative cohort of symptomatic HCWs, where 54/1597 (3.4%) tested positive for SARS-CoV-2 (ratio of symptomatic to asymptomatic 6.8:1). SARS-CoV-2 seroprevalence among 996 asymptomatic HCWs with no prior known exposure to SARS-CoV-2 was 1.4–3.4%, depending on assay. A novel in-house Coronavirus protein microarray showed differing SARS-CoV-2 protein reactivities and helped define likely true positives vs. suspected false positives. Our study demonstrates the utility of routine screening of asymptomatic HCWs, which may help to identify a significant proportion of infections. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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