Academic Journal
View in EDS

Genomic Profiling of Circulating Tumor DNA From Cerebrospinal Fluid to Guide Clinical Decision Making for Patients With Primary and Metastatic Brain Tumors.

Bibliographic Details
Title: Genomic Profiling of Circulating Tumor DNA From Cerebrospinal Fluid to Guide Clinical Decision Making for Patients With Primary and Metastatic Brain Tumors.
Authors: Ramkissoon, Lori A., Pegram, Worthy, Haberberger, James, Danziger, Natalie, Lesser, Glenn, Strowd, Roy, Dahiya, Sonika, Cummings, Thomas J., Bi, Wenya Linda, Abedalthagafi, Malak, Sathyan, Pratheesh, McGregor, Kimberly, Reddy, Prasanth, Severson, Eric, Williams, Erik, Lin, Douglas, Edgerly, Claire, Huang, Richard S. P., Hemmerich, Amanda, Creeden, James
Source: Frontiers in Neurology; 10/19/2020, Vol. 11, pN.PAG-N.PAG, 9p
Subject Terms: CIRCULATING tumor DNA, PATIENT decision making, CEREBROSPINAL fluid, BRAIN tumors, CENTRAL nervous system tumors, CENTRAL nervous system, OPERATIVE surgery
Abstract: Despite advances in systemic therapies for solid tumors, the development of brain metastases remains a significant contributor to overall cancer mortality and requires improved methods for diagnosing and treating these lesions. Similarly, the prognosis for malignant primary brain tumors remains poor with little improvement in overall survival over the last several decades. In both primary and metastatic central nervous system (CNS) tumors, the challenge from a clinical perspective centers on detecting CNS dissemination early and understanding how CNS lesions differ from the primary tumor, in order to determine potential treatment strategies. Acquiring tissue from CNS tumors has historically been accomplished through invasive neurosurgical procedures, which restricts the number of patients to those who can safely undergo a surgical procedure, and for which such interventions will add meaningful value to the care of the patient. In this review we discuss the potential of analyzing cell free DNA shed from tumor cells that is contained within the cerebrospinal fluid (CSF) as a sensitive and minimally invasive method to detect and characterize primary and metastatic tumors in the CNS. [ABSTRACT FROM AUTHOR]
Copyright of Frontiers in Neurology is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edb&genre=article&issn=16642295&ISBN=&volume=11&issue=&date=20201019&spage=N.PAG&pages=&title=Frontiers in Neurology&atitle=Genomic%20Profiling%20of%20Circulating%20Tumor%20DNA%20From%20Cerebrospinal%20Fluid%20to%20Guide%20Clinical%20Decision%20Making%20for%20Patients%20With%20Primary%20and%20Metastatic%20Brain%20Tumors.&aulast=Ramkissoon%2C%20Lori%20A.&id=DOI:10.3389/fneur.2020.544680
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: edb
DbLabel: Complementary Index
An: 146513928
RelevancyScore: 915
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 915.367736816406
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Genomic Profiling of Circulating Tumor DNA From Cerebrospinal Fluid to Guide Clinical Decision Making for Patients With Primary and Metastatic Brain Tumors.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Ramkissoon%2C+Lori+A%2E%22">Ramkissoon, Lori A.</searchLink><br /><searchLink fieldCode="AR" term="%22Pegram%2C+Worthy%22">Pegram, Worthy</searchLink><br /><searchLink fieldCode="AR" term="%22Haberberger%2C+James%22">Haberberger, James</searchLink><br /><searchLink fieldCode="AR" term="%22Danziger%2C+Natalie%22">Danziger, Natalie</searchLink><br /><searchLink fieldCode="AR" term="%22Lesser%2C+Glenn%22">Lesser, Glenn</searchLink><br /><searchLink fieldCode="AR" term="%22Strowd%2C+Roy%22">Strowd, Roy</searchLink><br /><searchLink fieldCode="AR" term="%22Dahiya%2C+Sonika%22">Dahiya, Sonika</searchLink><br /><searchLink fieldCode="AR" term="%22Cummings%2C+Thomas+J%2E%22">Cummings, Thomas J.</searchLink><br /><searchLink fieldCode="AR" term="%22Bi%2C+Wenya+Linda%22">Bi, Wenya Linda</searchLink><br /><searchLink fieldCode="AR" term="%22Abedalthagafi%2C+Malak%22">Abedalthagafi, Malak</searchLink><br /><searchLink fieldCode="AR" term="%22Sathyan%2C+Pratheesh%22">Sathyan, Pratheesh</searchLink><br /><searchLink fieldCode="AR" term="%22McGregor%2C+Kimberly%22">McGregor, Kimberly</searchLink><br /><searchLink fieldCode="AR" term="%22Reddy%2C+Prasanth%22">Reddy, Prasanth</searchLink><br /><searchLink fieldCode="AR" term="%22Severson%2C+Eric%22">Severson, Eric</searchLink><br /><searchLink fieldCode="AR" term="%22Williams%2C+Erik%22">Williams, Erik</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+Douglas%22">Lin, Douglas</searchLink><br /><searchLink fieldCode="AR" term="%22Edgerly%2C+Claire%22">Edgerly, Claire</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+Richard+S%2E+P%2E%22">Huang, Richard S. P.</searchLink><br /><searchLink fieldCode="AR" term="%22Hemmerich%2C+Amanda%22">Hemmerich, Amanda</searchLink><br /><searchLink fieldCode="AR" term="%22Creeden%2C+James%22">Creeden, James</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Frontiers in Neurology; 10/19/2020, Vol. 11, pN.PAG-N.PAG, 9p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22CIRCULATING+tumor+DNA%22">CIRCULATING tumor DNA</searchLink><br /><searchLink fieldCode="DE" term="%22PATIENT+decision+making%22">PATIENT decision making</searchLink><br /><searchLink fieldCode="DE" term="%22CEREBROSPINAL+fluid%22">CEREBROSPINAL fluid</searchLink><br /><searchLink fieldCode="DE" term="%22BRAIN+tumors%22">BRAIN tumors</searchLink><br /><searchLink fieldCode="DE" term="%22CENTRAL+nervous+system+tumors%22">CENTRAL nervous system tumors</searchLink><br /><searchLink fieldCode="DE" term="%22CENTRAL+nervous+system%22">CENTRAL nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22OPERATIVE+surgery%22">OPERATIVE surgery</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Despite advances in systemic therapies for solid tumors, the development of brain metastases remains a significant contributor to overall cancer mortality and requires improved methods for diagnosing and treating these lesions. Similarly, the prognosis for malignant primary brain tumors remains poor with little improvement in overall survival over the last several decades. In both primary and metastatic central nervous system (CNS) tumors, the challenge from a clinical perspective centers on detecting CNS dissemination early and understanding how CNS lesions differ from the primary tumor, in order to determine potential treatment strategies. Acquiring tissue from CNS tumors has historically been accomplished through invasive neurosurgical procedures, which restricts the number of patients to those who can safely undergo a surgical procedure, and for which such interventions will add meaningful value to the care of the patient. In this review we discuss the potential of analyzing cell free DNA shed from tumor cells that is contained within the cerebrospinal fluid (CSF) as a sensitive and minimally invasive method to detect and characterize primary and metastatic tumors in the CNS. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Frontiers in Neurology is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=146513928
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3389/fneur.2020.544680
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: N.PAG
    Subjects:
      – SubjectFull: CIRCULATING tumor DNA
        Type: general
      – SubjectFull: PATIENT decision making
        Type: general
      – SubjectFull: CEREBROSPINAL fluid
        Type: general
      – SubjectFull: BRAIN tumors
        Type: general
      – SubjectFull: CENTRAL nervous system tumors
        Type: general
      – SubjectFull: CENTRAL nervous system
        Type: general
      – SubjectFull: OPERATIVE surgery
        Type: general
    Titles:
      – TitleFull: Genomic Profiling of Circulating Tumor DNA From Cerebrospinal Fluid to Guide Clinical Decision Making for Patients With Primary and Metastatic Brain Tumors.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ramkissoon, Lori A.
      – PersonEntity:
          Name:
            NameFull: Pegram, Worthy
      – PersonEntity:
          Name:
            NameFull: Haberberger, James
      – PersonEntity:
          Name:
            NameFull: Danziger, Natalie
      – PersonEntity:
          Name:
            NameFull: Lesser, Glenn
      – PersonEntity:
          Name:
            NameFull: Strowd, Roy
      – PersonEntity:
          Name:
            NameFull: Dahiya, Sonika
      – PersonEntity:
          Name:
            NameFull: Cummings, Thomas J.
      – PersonEntity:
          Name:
            NameFull: Bi, Wenya Linda
      – PersonEntity:
          Name:
            NameFull: Abedalthagafi, Malak
      – PersonEntity:
          Name:
            NameFull: Sathyan, Pratheesh
      – PersonEntity:
          Name:
            NameFull: McGregor, Kimberly
      – PersonEntity:
          Name:
            NameFull: Reddy, Prasanth
      – PersonEntity:
          Name:
            NameFull: Severson, Eric
      – PersonEntity:
          Name:
            NameFull: Williams, Erik
      – PersonEntity:
          Name:
            NameFull: Lin, Douglas
      – PersonEntity:
          Name:
            NameFull: Edgerly, Claire
      – PersonEntity:
          Name:
            NameFull: Huang, Richard S. P.
      – PersonEntity:
          Name:
            NameFull: Hemmerich, Amanda
      – PersonEntity:
          Name:
            NameFull: Creeden, James
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 19
              M: 10
              Text: 10/19/2020
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-print
              Value: 16642295
          Numbering:
            – Type: volume
              Value: 11
          Titles:
            – TitleFull: Frontiers in Neurology
              Type: main
ResultId 1