Academic Journal
View in EDS

Cancer Stem Cells in Neuroblastoma: Expanding the Therapeutic Frontier.

Bibliographic Details
Title: Cancer Stem Cells in Neuroblastoma: Expanding the Therapeutic Frontier.
Authors: Bahmad, Hisham F., Chamaa, Farah, Assi, Sahar, Chalhoub, Reda M., Abou-Antoun, Tamara, Abou-Kheir, Wassim
Source: Frontiers in Molecular Neuroscience; 5/27/2019, pN.PAG-N.PAG, 17p
Subject Terms: CANCER stem cells, NEUROBLASTOMA, XENOGRAFTS, EMBRYONIC stem cells, NEOPLASTIC cell transformation
Abstract: Neuroblastoma (NB) is the most common extracranial solid tumor often diagnosed in childhood. Despite intense efforts to develop a successful treatment, current available therapies are still challenged by high rates of resistance, recurrence and progression, most notably in advanced cases and highly malignant tumors. Emerging evidence proposes that this might be due to a subpopulation of cancer stem cells (CSCs) or tumor-initiating cells (TICs) found in the bulk of the tumor. Therefore, the development of more targeted therapy is highly dependent on the identification of the molecular signatures and genetic aberrations characteristic to this subpopulation of cells. This review aims at providing an overview of the key molecular players involved in NB CSCs and focuses on the experimental evidence from NB cell lines, patient-derived xenografts and primary tumors. It also provides some novel approaches of targeting multiple drivers governing the stemness of CSCs to achieve better anti-tumor effects than the currently used therapeutic agents. [ABSTRACT FROM AUTHOR]
Copyright of Frontiers in Molecular Neuroscience is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edb&genre=article&issn=16625099&ISBN=&volume=&issue=&date=20190527&spage=N.PAG&pages=&title=Frontiers in Molecular Neuroscience&atitle=Cancer%20Stem%20Cells%20in%20Neuroblastoma%3A%20Expanding%20the%20Therapeutic%20Frontier.&aulast=Bahmad%2C%20Hisham%20F.&id=DOI:10.3389/fnmol.2019.00131
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: edb
DbLabel: Complementary Index
An: 136678821
RelevancyScore: 899
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 899.320922851563
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Cancer Stem Cells in Neuroblastoma: Expanding the Therapeutic Frontier.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Bahmad%2C+Hisham+F%2E%22">Bahmad, Hisham F.</searchLink><br /><searchLink fieldCode="AR" term="%22Chamaa%2C+Farah%22">Chamaa, Farah</searchLink><br /><searchLink fieldCode="AR" term="%22Assi%2C+Sahar%22">Assi, Sahar</searchLink><br /><searchLink fieldCode="AR" term="%22Chalhoub%2C+Reda+M%2E%22">Chalhoub, Reda M.</searchLink><br /><searchLink fieldCode="AR" term="%22Abou-Antoun%2C+Tamara%22">Abou-Antoun, Tamara</searchLink><br /><searchLink fieldCode="AR" term="%22Abou-Kheir%2C+Wassim%22">Abou-Kheir, Wassim</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Frontiers in Molecular Neuroscience; 5/27/2019, pN.PAG-N.PAG, 17p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22CANCER+stem+cells%22">CANCER stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22NEUROBLASTOMA%22">NEUROBLASTOMA</searchLink><br /><searchLink fieldCode="DE" term="%22XENOGRAFTS%22">XENOGRAFTS</searchLink><br /><searchLink fieldCode="DE" term="%22EMBRYONIC+stem+cells%22">EMBRYONIC stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22NEOPLASTIC+cell+transformation%22">NEOPLASTIC cell transformation</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Neuroblastoma (NB) is the most common extracranial solid tumor often diagnosed in childhood. Despite intense efforts to develop a successful treatment, current available therapies are still challenged by high rates of resistance, recurrence and progression, most notably in advanced cases and highly malignant tumors. Emerging evidence proposes that this might be due to a subpopulation of cancer stem cells (CSCs) or tumor-initiating cells (TICs) found in the bulk of the tumor. Therefore, the development of more targeted therapy is highly dependent on the identification of the molecular signatures and genetic aberrations characteristic to this subpopulation of cells. This review aims at providing an overview of the key molecular players involved in NB CSCs and focuses on the experimental evidence from NB cell lines, patient-derived xenografts and primary tumors. It also provides some novel approaches of targeting multiple drivers governing the stemness of CSCs to achieve better anti-tumor effects than the currently used therapeutic agents. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Frontiers in Molecular Neuroscience is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=136678821
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3389/fnmol.2019.00131
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 17
        StartPage: N.PAG
    Subjects:
      – SubjectFull: CANCER stem cells
        Type: general
      – SubjectFull: NEUROBLASTOMA
        Type: general
      – SubjectFull: XENOGRAFTS
        Type: general
      – SubjectFull: EMBRYONIC stem cells
        Type: general
      – SubjectFull: NEOPLASTIC cell transformation
        Type: general
    Titles:
      – TitleFull: Cancer Stem Cells in Neuroblastoma: Expanding the Therapeutic Frontier.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Bahmad, Hisham F.
      – PersonEntity:
          Name:
            NameFull: Chamaa, Farah
      – PersonEntity:
          Name:
            NameFull: Assi, Sahar
      – PersonEntity:
          Name:
            NameFull: Chalhoub, Reda M.
      – PersonEntity:
          Name:
            NameFull: Abou-Antoun, Tamara
      – PersonEntity:
          Name:
            NameFull: Abou-Kheir, Wassim
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 27
              M: 05
              Text: 5/27/2019
              Type: published
              Y: 2019
          Identifiers:
            – Type: issn-print
              Value: 16625099
          Titles:
            – TitleFull: Frontiers in Molecular Neuroscience
              Type: main
ResultId 1