Association of variants of miRNA processing genes with cervical precancerous lesion risk in a southern Chinese population.
| Title: | Association of variants of miRNA processing genes with cervical precancerous lesion risk in a southern Chinese population. |
|---|---|
| Authors: | Shi-Qi Huang, Zi-Xing Zhou, Shao-Ling Zheng, Dan-Dan Liu, Xiao-Hong Ye, Cheng-Li Zeng, Ya-Jing Han, Zi-Hao Wen, Xiao-Qian Zou, Jing Wu, Yu-Mei Liu, Chui-Can Huang, Yao Wang, Guang Yang, Chun-Xia Jing |
| Source: | Bioscience Reports; 6/29/2018, Vol. 38 Issue 3, p1-11, 11p, 4 Charts, 2 Graphs |
| Abstract: | The miRNA processing genes play essential roles in the biosynthesis of mammalian miRNAs, and their genetic variants are involved in the development of various cancers. Our study aimed to determine the potential association between miRNA processing gene polymorphisms and cervical precancerous lesions. Five single nucleotide polymorphisms (SNPs), including Ran-GTP (RAN) rs14035, exportin-5 (XPO5) rs11077, DICER1 rs3742330, DICER1 rs13078, and TARBP2 rs784567, were genotyped in a case–control study to estimate risk factors of cervical precancerous lesions. The gene–environment interactions and haplotype association were estimated. We identified a 27% decreased risk of cervical precancerous lesions for individuals with minor G allele in DICER1 rs3742330 (odds ratio (OR) = 0.73, 95% confidence interval (95% CI) = 0.58–0.92, P = 0.009). The AG and AG/GG genotypes in DICER1 rs3742330 were also found to decrease the risk of cervical precancerous lesions (AG compared with AA: OR = 0.51, 95% CI = 0.35–0.73, P <0.001; AG/GG compared with AA: OR = 0.54, 95% CI = 0.39–0.77, P = 0.001). The GT haplotype in DICER1 had a risk effect on cervical precancerous lesions compared with the AT haplotype (OR = 1.36, 95% CI = 1.08–1.73, P = 0.010). A two-factor (DICER1 rs3742330 and human papillomavirus (HPV) infection) and two three-factor (model 1: rs3742330, passive smoking, and HPV infection; model 2: rs3742330, abortion history, and HPV infection) interaction models for cervical precancerous lesions were identified. In conclusion, the genetic variants in the miRNA processing genes and interactions with certain environmental factors might contribute to the risk of cervical precancerous lesions in southern Chinese women. [ABSTRACT FROM AUTHOR] |
| Copyright of Bioscience Reports is the property of Portland Press Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Complementary Index |
Be the first to leave a comment!