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Occupational exposure to petroleum-based and oxygenated solvents and hypopharyngeal and laryngeal cancer in France: the ICARE study.

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Title: Occupational exposure to petroleum-based and oxygenated solvents and hypopharyngeal and laryngeal cancer in France: the ICARE study.
Authors: Barul, Christine, Carton, Matthieu, Radoï, Loredana, Menvielle, Gwenn, Pilorget, Corinne, Bara, Simona, Stücker, Isabelle, Luce, Danièle, ICARE study group
Source: BMC Cancer; 4/5/2018, Vol. 18 Issue 1, p1-9, 9p, 5 Charts
Abstract: Background: To examine associations between occupational exposure to petroleum-based and oxygenated solvents and the risk of hypopharyngeal and laryngeal cancer.Methods: ICARE is a large, frequency-matched population-based case-control study conducted in France. Lifetime occupational history, tobacco smoking and alcohol consumption were collected. Analyses were restricted to men and included 383 cases of hypopharyngeal cancer, 454 cases of laryngeal cancer, and 2780 controls. Job-exposure matrices were used to assess exposure to five petroleum-based solvents (benzene; gasoline; white spirits; diesel, fuels and kerosene; special petroleum products) and to five oxygenated solvents (alcohols; ketones and esters; ethylene glycol; diethyl ether; tetrahydrofuran). Odds ratios (ORs) adjusted for smoking, alcohol drinking and other potential confounders and 95% confidence intervals (CI) were estimated with unconditional logistic models.Results: No significant association was found between hypopharyngeal or laryngeal cancer risk and exposure to the solvents under study. Non-significantly elevated risks of hypopharyngeal cancer were found in men exposed to high cumulative levels of white spirits (OR = 1.46; 95% CI: 0.88-2.43) and tetrahydrofuran (OR = 2.63; 95CI%: 0.55-12.65), with some indication of a dose-response relationship (p for trend: 0.09 and 0.07 respectively).Conclusion: This study provides weak evidence for an association between hypopharyngeal cancer and exposure to white spirits and tetrahydrofuran, and overall does not suggest a substantial role of exposure to petroleum-based or oxygenated solvents in hypopharyngeal or laryngeal cancer risk. [ABSTRACT FROM AUTHOR]
Copyright of BMC Cancer is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Occupational exposure to petroleum-based and oxygenated solvents and hypopharyngeal and laryngeal cancer in France: the ICARE study.
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  Data: <searchLink fieldCode="AR" term="%22Barul%2C+Christine%22">Barul, Christine</searchLink><br /><searchLink fieldCode="AR" term="%22Carton%2C+Matthieu%22">Carton, Matthieu</searchLink><br /><searchLink fieldCode="AR" term="%22Radoï%2C+Loredana%22">Radoï, Loredana</searchLink><br /><searchLink fieldCode="AR" term="%22Menvielle%2C+Gwenn%22">Menvielle, Gwenn</searchLink><br /><searchLink fieldCode="AR" term="%22Pilorget%2C+Corinne%22">Pilorget, Corinne</searchLink><br /><searchLink fieldCode="AR" term="%22Bara%2C+Simona%22">Bara, Simona</searchLink><br /><searchLink fieldCode="AR" term="%22Stücker%2C+Isabelle%22">Stücker, Isabelle</searchLink><br /><searchLink fieldCode="AR" term="%22Luce%2C+Danièle%22">Luce, Danièle</searchLink><br /><searchLink fieldCode="AR" term="%22ICARE+study+group%22">ICARE study group</searchLink>
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  Data: BMC Cancer; 4/5/2018, Vol. 18 Issue 1, p1-9, 9p, 5 Charts
– Name: Abstract
  Label: Abstract
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  Data: <bold>Background: </bold>To examine associations between occupational exposure to petroleum-based and oxygenated solvents and the risk of hypopharyngeal and laryngeal cancer.<bold>Methods: </bold>ICARE is a large, frequency-matched population-based case-control study conducted in France. Lifetime occupational history, tobacco smoking and alcohol consumption were collected. Analyses were restricted to men and included 383 cases of hypopharyngeal cancer, 454 cases of laryngeal cancer, and 2780 controls. Job-exposure matrices were used to assess exposure to five petroleum-based solvents (benzene; gasoline; white spirits; diesel, fuels and kerosene; special petroleum products) and to five oxygenated solvents (alcohols; ketones and esters; ethylene glycol; diethyl ether; tetrahydrofuran). Odds ratios (ORs) adjusted for smoking, alcohol drinking and other potential confounders and 95% confidence intervals (CI) were estimated with unconditional logistic models.<bold>Results: </bold>No significant association was found between hypopharyngeal or laryngeal cancer risk and exposure to the solvents under study. Non-significantly elevated risks of hypopharyngeal cancer were found in men exposed to high cumulative levels of white spirits (OR = 1.46; 95% CI: 0.88-2.43) and tetrahydrofuran (OR = 2.63; 95CI%: 0.55-12.65), with some indication of a dose-response relationship (p for trend: 0.09 and 0.07 respectively).<bold>Conclusion: </bold>This study provides weak evidence for an association between hypopharyngeal cancer and exposure to white spirits and tetrahydrofuran, and overall does not suggest a substantial role of exposure to petroleum-based or oxygenated solvents in hypopharyngeal or laryngeal cancer risk. [ABSTRACT FROM AUTHOR]
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  Label:
  Group: Ab
  Data: <i>Copyright of BMC Cancer is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: 4/5/2018
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