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AGTR1 promoter hypermethylation in lung squamous cell carcinoma but not in lung adenocarcinoma.

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Title: AGTR1 promoter hypermethylation in lung squamous cell carcinoma but not in lung adenocarcinoma.
Authors: RUHUA CHEN, QINGXIAO HONG, JIANZHONG JIANG, XIAOYING CHEN, ZHENHUAN JIANG, JINZHI WANG, SHUNLIN LIU, SHIWEI DUAN, SHUNBIN SHI
Source: Oncology Letters; Oct2017, Vol. 14 Issue 4, p4989-4994, 6p
Subject Terms: NON-small-cell lung carcinoma, DNA methylation, BIOMARKERS, GENE expression, ANGIOTENSIN II, PROGNOSIS
Abstract: Aberrant DNA methylation is associated with non-small cell lung cancer (NSCLC), suggesting that gene promoter methylation may be a potential biomarker for the detection or risk prediction of NSCLC. The present study aimed to evaluate the potential usage of angiotensin II receptor type 1 (AGTR1) methylation in two major pathologic subtypes: Lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Quantitative methylation-specific polymerase chain reaction was used to investigate the effect of AGTR1 promoter methylation in the tumor and the paired adjacent non-tumor tissue samples from 42 patients with LUSC, and 69 with LUAD. The percentage of methylated reference was calculated and presented as the median (interquartile range 25th-75th percentile). The results of the current study revealed that there was significantly increased AGTR1 promoter methylation in the tumor tissues compared with the paired adjacent non-tumor tissue [97.4 (57.22-130.5) vs. 85 (48.25-123); P=0.024]. Furthermore, higher AGTR1 promoter methylation was observed in patients with LUSC compared with LUAD (odds ratio=2.483; 95% confidence interval=1.125-5.480; P=0.023). Significant differences were identified in AGTR1 methylation between non-tumor and the tumor tissues in LUSC [113.5 (68.33-148.73) vs. 93.04 (45.94-140); P=0.008]. In addition, the Cancer Genome Atlas data of 378 patients with LUSC and 477 with LUAD revealed an inverse correlation between gene expression and the methylation status of AGTR1 promoter.. These data suggest that AGTR1 hypermethylation is a promising biomarker to assist in LUSC detection and diagnosis. [ABSTRACT FROM AUTHOR]
Copyright of Oncology Letters is the property of Spandidos Publications UK Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: AGTR1 promoter hypermethylation in lung squamous cell carcinoma but not in lung adenocarcinoma.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22RUHUA+CHEN%22">RUHUA CHEN</searchLink><br /><searchLink fieldCode="AR" term="%22QINGXIAO+HONG%22">QINGXIAO HONG</searchLink><br /><searchLink fieldCode="AR" term="%22JIANZHONG+JIANG%22">JIANZHONG JIANG</searchLink><br /><searchLink fieldCode="AR" term="%22XIAOYING+CHEN%22">XIAOYING CHEN</searchLink><br /><searchLink fieldCode="AR" term="%22ZHENHUAN+JIANG%22">ZHENHUAN JIANG</searchLink><br /><searchLink fieldCode="AR" term="%22JINZHI+WANG%22">JINZHI WANG</searchLink><br /><searchLink fieldCode="AR" term="%22SHUNLIN+LIU%22">SHUNLIN LIU</searchLink><br /><searchLink fieldCode="AR" term="%22SHIWEI+DUAN%22">SHIWEI DUAN</searchLink><br /><searchLink fieldCode="AR" term="%22SHUNBIN+SHI%22">SHUNBIN SHI</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Oncology Letters; Oct2017, Vol. 14 Issue 4, p4989-4994, 6p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22NON-small-cell+lung+carcinoma%22">NON-small-cell lung carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+methylation%22">DNA methylation</searchLink><br /><searchLink fieldCode="DE" term="%22BIOMARKERS%22">BIOMARKERS</searchLink><br /><searchLink fieldCode="DE" term="%22GENE+expression%22">GENE expression</searchLink><br /><searchLink fieldCode="DE" term="%22ANGIOTENSIN+II%22">ANGIOTENSIN II</searchLink><br /><searchLink fieldCode="DE" term="%22PROGNOSIS%22">PROGNOSIS</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Aberrant DNA methylation is associated with non-small cell lung cancer (NSCLC), suggesting that gene promoter methylation may be a potential biomarker for the detection or risk prediction of NSCLC. The present study aimed to evaluate the potential usage of angiotensin II receptor type 1 (AGTR1) methylation in two major pathologic subtypes: Lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Quantitative methylation-specific polymerase chain reaction was used to investigate the effect of AGTR1 promoter methylation in the tumor and the paired adjacent non-tumor tissue samples from 42 patients with LUSC, and 69 with LUAD. The percentage of methylated reference was calculated and presented as the median (interquartile range 25th-75th percentile). The results of the current study revealed that there was significantly increased AGTR1 promoter methylation in the tumor tissues compared with the paired adjacent non-tumor tissue [97.4 (57.22-130.5) vs. 85 (48.25-123); P=0.024]. Furthermore, higher AGTR1 promoter methylation was observed in patients with LUSC compared with LUAD (odds ratio=2.483; 95% confidence interval=1.125-5.480; P=0.023). Significant differences were identified in AGTR1 methylation between non-tumor and the tumor tissues in LUSC [113.5 (68.33-148.73) vs. 93.04 (45.94-140); P=0.008]. In addition, the Cancer Genome Atlas data of 378 patients with LUSC and 477 with LUAD revealed an inverse correlation between gene expression and the methylation status of AGTR1 promoter.. These data suggest that AGTR1 hypermethylation is a promising biomarker to assist in LUSC detection and diagnosis. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Oncology Letters is the property of Spandidos Publications UK Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3892/ol.2017.6824
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        Text: English
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        StartPage: 4989
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      – SubjectFull: NON-small-cell lung carcinoma
        Type: general
      – SubjectFull: DNA methylation
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      – SubjectFull: ANGIOTENSIN II
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      – TitleFull: AGTR1 promoter hypermethylation in lung squamous cell carcinoma but not in lung adenocarcinoma.
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              Text: Oct2017
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