Oral oestrogen reverses ovariectomy-induced morning surge hypertension in growth-restricted mice.
| Title: | Oral oestrogen reverses ovariectomy-induced morning surge hypertension in growth-restricted mice. |
|---|---|
| Authors: | Haskell, Sarah E., Peotta, Veronica, Reinking, Benjamin E., Catherine Zhang, Vivian Zhu, Kenkel, Elizabeth J., Roghair, Robert D. |
| Source: | Clinical Science; Apr2016, Vol. 130 Issue 8, p613-623, 11p |
| Subject Terms: | OVARIECTOMY, OVARIAN surgery, LABORATORY mice, HYPERTENSION, SYSTOLIC blood pressure, HYPERTROPHY |
| Abstract: | Perinatal growth restriction (GR) is associated with heightened sympathetic tone and hypertension. We have previously shown that naturally occurring neonatal GR programmes hypertension in male but not female mice. We therefore hypothesized that intact ovarian function or post-ovariectomy (OVX) oestrogen administration protects GR female mice from hypertension. Utilizing a non-interventional model that categorizes mice with weanling weights below the tenth percentile as GR, control and GR adult mice were studied at three distinct time points: baseline, post-OVX and post-OVX with oral oestrogen replacement. OVX elicited hypertension in GR mice that was significantly exacerbated by psychomotor arousal (systolic blood pressure at light to dark transition: control 122± 2; GR 119± 2; control-OVX 116± 3; GR-OVX 126± 3 mmHg). Oestrogen partially normalized the rising blood pressure surge seen in GR-OVX mice (23± 7% reduction). GR mice had left ventricular hypertrophy, and GR-OVX mice in particular had exaggerated bradycardic responses to sympathetic blockade. For GR mice, a baseline increase in baroreceptor reflex sensitivity and high frequency spectral power support a vagal compensatory mechanism, and that compensation was lost following OVX. For GR mice, the OVX-induced parasympathetic withdrawal was partially restored by oestrogen (40± 25% increase in high frequency spectral power, P<0.05). In conclusion, GR alters cardiac morphology and cardiovascular regulation. The haemodynamic consequences of GR are attenuated in ovarian-sufficient or oestrogen-replete females. Further investigations are needed to define the role of hormone replacement therapy targeted towards young women with oestrogen deficiency and additional cardiovascular risk factors, including perinatal GR, cardiac hypertrophy and morning surge hypertension. [ABSTRACT FROM AUTHOR] |
| Copyright of Clinical Science is the property of Portland Press Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Complementary Index |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edb&genre=article&issn=01435221&ISBN=&volume=130&issue=8&date=20160402&spage=613&pages=613-623&title=Clinical Science&atitle=Oral%20oestrogen%20reverses%20ovariectomy-induced%20morning%20surge%20hypertension%20in%20growth-restricted%20mice.&aulast=Haskell%2C%20Sarah%20E.&id=DOI:10.1042/CS20150693 Name: Full Text Finder (for New FTF UI) (s8985755) Category: fullText Text: Find It @ SCU Libraries MouseOverText: Find It @ SCU Libraries |
|---|---|
| Header | DbId: edb DbLabel: Complementary Index An: 113634166 RelevancyScore: 861 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 861.061340332031 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Oral oestrogen reverses ovariectomy-induced morning surge hypertension in growth-restricted mice. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Haskell%2C+Sarah+E%2E%22">Haskell, Sarah E.</searchLink><br /><searchLink fieldCode="AR" term="%22Peotta%2C+Veronica%22">Peotta, Veronica</searchLink><br /><searchLink fieldCode="AR" term="%22Reinking%2C+Benjamin+E%2E%22">Reinking, Benjamin E.</searchLink><br /><searchLink fieldCode="AR" term="%22Catherine+Zhang%22">Catherine Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Vivian+Zhu%22">Vivian Zhu</searchLink><br /><searchLink fieldCode="AR" term="%22Kenkel%2C+Elizabeth+J%2E%22">Kenkel, Elizabeth J.</searchLink><br /><searchLink fieldCode="AR" term="%22Roghair%2C+Robert+D%2E%22">Roghair, Robert D.</searchLink> – Name: TitleSource Label: Source Group: Src Data: Clinical Science; Apr2016, Vol. 130 Issue 8, p613-623, 11p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22OVARIECTOMY%22">OVARIECTOMY</searchLink><br /><searchLink fieldCode="DE" term="%22OVARIAN+surgery%22">OVARIAN surgery</searchLink><br /><searchLink fieldCode="DE" term="%22LABORATORY+mice%22">LABORATORY mice</searchLink><br /><searchLink fieldCode="DE" term="%22HYPERTENSION%22">HYPERTENSION</searchLink><br /><searchLink fieldCode="DE" term="%22SYSTOLIC+blood+pressure%22">SYSTOLIC blood pressure</searchLink><br /><searchLink fieldCode="DE" term="%22HYPERTROPHY%22">HYPERTROPHY</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Perinatal growth restriction (GR) is associated with heightened sympathetic tone and hypertension. We have previously shown that naturally occurring neonatal GR programmes hypertension in male but not female mice. We therefore hypothesized that intact ovarian function or post-ovariectomy (OVX) oestrogen administration protects GR female mice from hypertension. Utilizing a non-interventional model that categorizes mice with weanling weights below the tenth percentile as GR, control and GR adult mice were studied at three distinct time points: baseline, post-OVX and post-OVX with oral oestrogen replacement. OVX elicited hypertension in GR mice that was significantly exacerbated by psychomotor arousal (systolic blood pressure at light to dark transition: control 122± 2; GR 119± 2; control-OVX 116± 3; GR-OVX 126± 3 mmHg). Oestrogen partially normalized the rising blood pressure surge seen in GR-OVX mice (23± 7% reduction). GR mice had left ventricular hypertrophy, and GR-OVX mice in particular had exaggerated bradycardic responses to sympathetic blockade. For GR mice, a baseline increase in baroreceptor reflex sensitivity and high frequency spectral power support a vagal compensatory mechanism, and that compensation was lost following OVX. For GR mice, the OVX-induced parasympathetic withdrawal was partially restored by oestrogen (40± 25% increase in high frequency spectral power, P<0.05). In conclusion, GR alters cardiac morphology and cardiovascular regulation. The haemodynamic consequences of GR are attenuated in ovarian-sufficient or oestrogen-replete females. Further investigations are needed to define the role of hormone replacement therapy targeted towards young women with oestrogen deficiency and additional cardiovascular risk factors, including perinatal GR, cardiac hypertrophy and morning surge hypertension. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Clinical Science is the property of Portland Press Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=113634166 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1042/CS20150693 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 613 Subjects: – SubjectFull: OVARIECTOMY Type: general – SubjectFull: OVARIAN surgery Type: general – SubjectFull: LABORATORY mice Type: general – SubjectFull: HYPERTENSION Type: general – SubjectFull: SYSTOLIC blood pressure Type: general – SubjectFull: HYPERTROPHY Type: general Titles: – TitleFull: Oral oestrogen reverses ovariectomy-induced morning surge hypertension in growth-restricted mice. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Haskell, Sarah E. – PersonEntity: Name: NameFull: Peotta, Veronica – PersonEntity: Name: NameFull: Reinking, Benjamin E. – PersonEntity: Name: NameFull: Catherine Zhang – PersonEntity: Name: NameFull: Vivian Zhu – PersonEntity: Name: NameFull: Kenkel, Elizabeth J. – PersonEntity: Name: NameFull: Roghair, Robert D. IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 04 Text: Apr2016 Type: published Y: 2016 Identifiers: – Type: issn-print Value: 01435221 Numbering: – Type: volume Value: 130 – Type: issue Value: 8 Titles: – TitleFull: Clinical Science Type: main |
| ResultId | 1 |