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New radiographic bone erosions in the wrists of patients with rheumatoid arthritis are detectable with magnetic resonance imaging a median of two years earlier.

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Title: New radiographic bone erosions in the wrists of patients with rheumatoid arthritis are detectable with magnetic resonance imaging a median of two years earlier.
Authors: Mikkel Østergaard, Michael Hansen, Michael Stoltenberg, Karl Erik Jensen, Marcin Szkudlarek, Brigitta Pedersen-Zbinden, Ib Lorenzen
Source: Arthritis & Rheumatism; Aug2003, Vol. 48 Issue 8, p2128, 4p
Subject Terms: JOINT diseases, MAGNETIC resonance imaging, RADIOGRAPHY, RHEUMATOID arthritis, PATIENTS, BONES, WRIST
Abstract: In a 5-year followup study, we investigated the temporal relationship between development of wrist joint erosions as visualized by magnetic resonance imaging (MRI) versus conventional radiography (CR), in patients with rheumatoid arthritis. We also evaluated the risk of erosive progression on CR associated with the presence of MRI erosions. In 10 patients with rheumatoid arthritis, MRI and CR of the dominant wrist were performed annually for 5 years. In each image set, each wrist bone (metacarpal bases, carpal bones, radius, and ulna) was assessed for the absence or presence of bone erosions. Nine bones showed radiographic erosions at baseline. Twenty-seven new radiographic erosions developed during the 5-year followup period. Of these 27 new erosions, 21 were detected 1–5 years earlier by MRI than by CR, 3 were simultaneously detected by both methods, 2 were detected 1–2 years later by MRI than by CR, and 1 erosion (radiographically detected at 5-year followup) was not visualized with MRI. MRI detection of new radiographic erosions preceded CR detection by a median of 2 years. In bones with MRI erosions at baseline, the relative risk of radiographic erosions at 5-year followup was 4.5 (95% confidence interval [95% CI] 2.6–7.6), compared with bones without baseline MRI erosions. If bones with baseline radiographic erosions were excluded from the analysis, the relative risk was 4.1 (95% CI 2.2–7.5). Most new radiographic bone erosions (78%) were visualized at least 1 year earlier by MRI than by CR. This illustrates that the information on joint destruction provided by CR is considerably delayed compared with that provided by MRI. A significantly increased risk of progression of radiographic erosion in bones with baseline MRI erosions was observed, demonstrating a prognostic value of MRI with respect to long-term radiographic outcome. [ABSTRACT FROM AUTHOR]
Copyright of Arthritis & Rheumatism is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: New radiographic bone erosions in the wrists of patients with rheumatoid arthritis are detectable with magnetic resonance imaging a median of two years earlier.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Mikkel+Østergaard%22">Mikkel Østergaard</searchLink><br /><searchLink fieldCode="AR" term="%22Michael+Hansen%22">Michael Hansen</searchLink><br /><searchLink fieldCode="AR" term="%22Michael+Stoltenberg%22">Michael Stoltenberg</searchLink><br /><searchLink fieldCode="AR" term="%22Karl+Erik+Jensen%22">Karl Erik Jensen</searchLink><br /><searchLink fieldCode="AR" term="%22Marcin+Szkudlarek%22">Marcin Szkudlarek</searchLink><br /><searchLink fieldCode="AR" term="%22Brigitta+Pedersen-Zbinden%22">Brigitta Pedersen-Zbinden</searchLink><br /><searchLink fieldCode="AR" term="%22Ib+Lorenzen%22">Ib Lorenzen</searchLink>
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  Label: Source
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  Data: Arthritis & Rheumatism; Aug2003, Vol. 48 Issue 8, p2128, 4p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22JOINT+diseases%22">JOINT diseases</searchLink><br /><searchLink fieldCode="DE" term="%22MAGNETIC+resonance+imaging%22">MAGNETIC resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22RADIOGRAPHY%22">RADIOGRAPHY</searchLink><br /><searchLink fieldCode="DE" term="%22RHEUMATOID+arthritis%22">RHEUMATOID arthritis</searchLink><br /><searchLink fieldCode="DE" term="%22PATIENTS%22">PATIENTS</searchLink><br /><searchLink fieldCode="DE" term="%22BONES%22">BONES</searchLink><br /><searchLink fieldCode="DE" term="%22WRIST%22">WRIST</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: In a 5-year followup study, we investigated the temporal relationship between development of wrist joint erosions as visualized by magnetic resonance imaging (MRI) versus conventional radiography (CR), in patients with rheumatoid arthritis. We also evaluated the risk of erosive progression on CR associated with the presence of MRI erosions. In 10 patients with rheumatoid arthritis, MRI and CR of the dominant wrist were performed annually for 5 years. In each image set, each wrist bone (metacarpal bases, carpal bones, radius, and ulna) was assessed for the absence or presence of bone erosions. Nine bones showed radiographic erosions at baseline. Twenty-seven new radiographic erosions developed during the 5-year followup period. Of these 27 new erosions, 21 were detected 1–5 years earlier by MRI than by CR, 3 were simultaneously detected by both methods, 2 were detected 1–2 years later by MRI than by CR, and 1 erosion (radiographically detected at 5-year followup) was not visualized with MRI. MRI detection of new radiographic erosions preceded CR detection by a median of 2 years. In bones with MRI erosions at baseline, the relative risk of radiographic erosions at 5-year followup was 4.5 (95% confidence interval [95% CI] 2.6–7.6), compared with bones without baseline MRI erosions. If bones with baseline radiographic erosions were excluded from the analysis, the relative risk was 4.1 (95% CI 2.2–7.5). Most new radiographic bone erosions (78%) were visualized at least 1 year earlier by MRI than by CR. This illustrates that the information on joint destruction provided by CR is considerably delayed compared with that provided by MRI. A significantly increased risk of progression of radiographic erosion in bones with baseline MRI erosions was observed, demonstrating a prognostic value of MRI with respect to long-term radiographic outcome. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Arthritis & Rheumatism is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Code: eng
        Text: English
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        PageCount: 4
        StartPage: 2128
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      – SubjectFull: JOINT diseases
        Type: general
      – SubjectFull: MAGNETIC resonance imaging
        Type: general
      – SubjectFull: RADIOGRAPHY
        Type: general
      – SubjectFull: RHEUMATOID arthritis
        Type: general
      – SubjectFull: PATIENTS
        Type: general
      – SubjectFull: BONES
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      – SubjectFull: WRIST
        Type: general
    Titles:
      – TitleFull: New radiographic bone erosions in the wrists of patients with rheumatoid arthritis are detectable with magnetic resonance imaging a median of two years earlier.
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            NameFull: Mikkel Østergaard
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            NameFull: Michael Hansen
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            NameFull: Brigitta Pedersen-Zbinden
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            NameFull: Ib Lorenzen
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            – D: 01
              M: 08
              Text: Aug2003
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              Y: 2003
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