Bibliographic Details
| Title: |
Network Pharmacology and Molecular Docking Analyses of the Mechanism of Action of Berberine in the Treatment of Melanoma. |
| Authors: |
Zhongshun He1,2,3, Aiping Huang4, Jing Lv5, Jing Zhou1,2,6, Wenrong Lou3, Xuesong Wu7 kmykdwxs139@163.com, Biao Xu1,2 xubiao@kmmu.edu.cn |
| Source: |
Current Topics in Nutraceutical Research. Aug2024, Vol. 22 Issue 3, p1058-1063. 6p. |
| Subject Terms: |
*Research funding, Computer-assisted molecular modeling, Alkaloids, Melanoma, Genomics, Pharmaceutical chemistry, Antineoplastic agents, Phytochemicals, Cellular signal transduction, Tumor markers, Liver cells, Bioinformatics, Molecular structure, Cell receptors |
| Abstract: |
Melanoma is a cutaneum carcinoma caused by the malignant transformation of melanocytes. This study aimed to predict potential targets of berberine in melanoma treatment and its mechanism of action through a network pharmacological analysis. The GeneCards databases and SwissTargetPrediction yielded five overlapped targets, including RAC1, CDK4, KIT, and CHEK2. The components-targets network diagram indicated that berberine interacted with the targets. The molecular docking showed that berberine exhibited a high binding affinity with all five targets and bound to them through hydrogen bonding and hydrophobicity. Furthermore, gene ontology enrichment analysis revealed that these targets were primarily involved in the hepatocyte growth factor receptor signaling pathway, followed by positive regulation of microtubule polymerization. The PI3K-Akt, Rap1, and Ras signaling pathways were the most significant influences in the Kyoto Encyclopedia of Genes and Genome analysis. This study predicted that berberine may be involved in the hepatocyte growth factor receptor signaling pathway and the PI3K-Akt signaling pathway in melanoma through MET, RAC1, CDK4, KIT, and CHEK2 through network pharmacological methods. [ABSTRACT FROM AUTHOR] |
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| Database: |
Business Source Complete |
