Studying Epstein-Barr Virus Pathologies and Immune Surveillance by Reconstructing EBV Infection in Mice.
| Title: | Studying Epstein-Barr Virus Pathologies and Immune Surveillance by Reconstructing EBV Infection in Mice. |
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| Authors: | TOMOHARU YASUDA1 tomoharu.yasuda@mdc-berlin.de, WIRTZ, TRISTAN1, BAOCHUN ZHANG2, WUNDERLICH, THOMAS3, SCHMIDT-SUPPRIAN, MARC4, SOMMERMANN, THOMAS1,3, RAJEWSKY, KLAUS1 klaus.rajewsky@mdc-berlin.de |
| Source: | Cold Spring Harbor Symposia on Quantitative Biology. 2013, Vol. 78, p259-263. 5p. |
| Subject Terms: | *IMMUNE response, *LABORATORY mice, *B cells, *GENE expression |
| Abstract: | The article presents a study on Epstein-Barr virus (EBV) pathologies and immune surveillance modeling in mice. It focused initial experiments on inducing EBV immune surveillance and lymphomagenesis by B-cell specific expression of EBV latent membrane proteins (LMPs) 1 and 2A in mouse B cells. Results show that the basic features of acute EBV infection like infected B cell expansion can be modeled in the mouse through induced expression of a single EBV protein, LMP1 in a fraction of its B cells. |
| Database: | Academic Search Complete |
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