5-Fluorouracil: mechanisms of action and clinical strategies.
| Title: | 5-Fluorouracil: mechanisms of action and clinical strategies. |
|---|---|
| Authors: | Longley, Daniel B., Harkin, D. Paul, Johnston, Patrick G. |
| Source: | Nature Reviews Cancer. May2003, Vol. 3 Issue 5, p330. 9p. |
| Subject Terms: | *FLUOROURACIL, *CANCER treatment, *DRUG therapy, *BIOMARKERS, *DNA microarrays |
| Abstract: | 5-Fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led to the development of strategies that increase its anticancer activity. Despite these advances, drug resistance remains a significant limitation to the clinical use of 5-FU. Emerging technologies, such as DNA microarray profiling, have the potential to identify novel genes that are involved in mediating resistance to 5-FU. Such target genes might prove to be therapeutically valuable as new targets for chemotherapy, or as predictive biomarkers of response to 5-FU-based chemotherapy. [ABSTRACT FROM AUTHOR] |
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| Database: | Academic Search Complete |
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