Expression of vascular endothelial growth factor-C and its receptor in invasive micropapillary carcinoma of the breast.
| Title: | Expression of vascular endothelial growth factor-C and its receptor in invasive micropapillary carcinoma of the breast. |
|---|---|
| Authors: | Yu-sang Li1, Kaneko, Mayumi1, Amatya, Vishwa Jeet1, Takeshima, Yukio1, Arihiro, Koji2, Inai, Kouki1 koinai@hiroshima-u.ac.jp |
| Source: | Pathology International. May2006, Vol. 56 Issue 5, p256-261. 6p. 3 Color Photographs, 5 Charts. |
| Subject Terms: | *BREAST cancer, *LYMPH nodes, *METASTASIS, *VASCULAR endothelial growth factors, *NEOVASCULARIZATION, *CANCER cells |
| Abstract: | Invasion to lymphatic vessels and metastasis to lymph nodes are frequent complications in invasive micropapillary carcinoma (IMPC) of human breast cancer. Vascular endothelial growth factor-C (VEGF-C) and its receptor, VEGFR-3 have been implicated as the important factors in the formation of lymphatic vessels and recent experimental evidence strongly suggests that lymphangiogenesis in tumor promotes lymphatic metastasis. To clarify the mechanism of its occurrence, the expression of VEGF-C, VEGFR-3 and lymphatic vessel density (LVD) was examined in 40 cases of IMPC (pure and mixed type) and in 40 cases of pseudo-IMPC. Cytoplasmic expression of VEGF-C and VEGFR-3 were more frequent in tumor cells of IMPC compared to those of pseudo-IMPC. A significant positive correlation was found between the expression of VEGF-C and VEGFR-3 in both IMPC and pseudo-IMPC. The expression of VEGF-C was also significantly associated with higher peritumoral LVD, lymphatic invasion and number of lymph node metastasis in IMPC. These findings suggest that VEGF-C promotes the proliferation of peritumoral lymphatic vessels and that lymphatic invasion and metastasis to lymph nodes are frequently induced in IMPC of breast. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Expression of vascular endothelial growth factor-C and its receptor in invasive micropapillary carcinoma of the breast. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Yu-sang+Li%22">Yu-sang Li</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kaneko%2C+Mayumi%22">Kaneko, Mayumi</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Amatya%2C+Vishwa+Jeet%22">Amatya, Vishwa Jeet</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Takeshima%2C+Yukio%22">Takeshima, Yukio</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Arihiro%2C+Koji%22">Arihiro, Koji</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Inai%2C+Kouki%22">Inai, Kouki</searchLink><relatesTo>1</relatesTo><i> koinai@hiroshima-u.ac.jp</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pathology+International%22">Pathology International</searchLink>. May2006, Vol. 56 Issue 5, p256-261. 6p. 3 Color Photographs, 5 Charts. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22BREAST+cancer%22">BREAST cancer</searchLink><br />*<searchLink fieldCode="DE" term="%22LYMPH+nodes%22">LYMPH nodes</searchLink><br />*<searchLink fieldCode="DE" term="%22METASTASIS%22">METASTASIS</searchLink><br />*<searchLink fieldCode="DE" term="%22VASCULAR+endothelial+growth+factors%22">VASCULAR endothelial growth factors</searchLink><br />*<searchLink fieldCode="DE" term="%22NEOVASCULARIZATION%22">NEOVASCULARIZATION</searchLink><br />*<searchLink fieldCode="DE" term="%22CANCER+cells%22">CANCER cells</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Invasion to lymphatic vessels and metastasis to lymph nodes are frequent complications in invasive micropapillary carcinoma (IMPC) of human breast cancer. Vascular endothelial growth factor-C (VEGF-C) and its receptor, VEGFR-3 have been implicated as the important factors in the formation of lymphatic vessels and recent experimental evidence strongly suggests that lymphangiogenesis in tumor promotes lymphatic metastasis. To clarify the mechanism of its occurrence, the expression of VEGF-C, VEGFR-3 and lymphatic vessel density (LVD) was examined in 40 cases of IMPC (pure and mixed type) and in 40 cases of pseudo-IMPC. Cytoplasmic expression of VEGF-C and VEGFR-3 were more frequent in tumor cells of IMPC compared to those of pseudo-IMPC. A significant positive correlation was found between the expression of VEGF-C and VEGFR-3 in both IMPC and pseudo-IMPC. The expression of VEGF-C was also significantly associated with higher peritumoral LVD, lymphatic invasion and number of lymph node metastasis in IMPC. These findings suggest that VEGF-C promotes the proliferation of peritumoral lymphatic vessels and that lymphatic invasion and metastasis to lymph nodes are frequently induced in IMPC of breast. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pathology International is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1440-1827.2006.01961.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 256 Subjects: – SubjectFull: BREAST cancer Type: general – SubjectFull: LYMPH nodes Type: general – SubjectFull: METASTASIS Type: general – SubjectFull: VASCULAR endothelial growth factors Type: general – SubjectFull: NEOVASCULARIZATION Type: general – SubjectFull: CANCER cells Type: general Titles: – TitleFull: Expression of vascular endothelial growth factor-C and its receptor in invasive micropapillary carcinoma of the breast. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yu-sang Li – PersonEntity: Name: NameFull: Kaneko, Mayumi – PersonEntity: Name: NameFull: Amatya, Vishwa Jeet – PersonEntity: Name: NameFull: Takeshima, Yukio – PersonEntity: Name: NameFull: Arihiro, Koji – PersonEntity: Name: NameFull: Inai, Kouki IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 13205463 Numbering: – Type: volume Value: 56 – Type: issue Value: 5 Titles: – TitleFull: Pathology International Type: main |
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