Poly(ethylene glycol) hydrogels cross-linked by hydrolyzable polyrotaxane containing hydroxyapatite particles as scaffolds for bone regeneration.
| Title: | Poly(ethylene glycol) hydrogels cross-linked by hydrolyzable polyrotaxane containing hydroxyapatite particles as scaffolds for bone regeneration. |
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| Authors: | Fujimoto, Mariko1, Isobe, Masatsugu1, Yamaguchi, Satoshi1 yamachan.mfs@tmd.ac.jp, Amagasa, Teruo1, Watanabe, Akihiko2, Ooya, Tooru3, Yui, Nobuhiko3 yui@jaist.ac.jp |
| Source: | Journal of Biomaterials Science -- Polymer Edition. Dec2005, Vol. 16 Issue 12, p1611-1621. 11p. 5 Diagrams, 1 Chart, 1 Graph. |
| Subject Terms: | *BONE regeneration, *POLYETHYLENE glycol, *HYDROGELS, *HYDROXYAPATITE, *CELL adhesion |
| Abstract: | Poly(ethylene glycol) (PEG) hydrogels cross-linked by a hydrolyzable polyrotaxane containing hydroxyapatite particles (PRX-HAp) were developed as scaffolds for bone regeneration. Five scaffolds with various composition of the polyrotaxane, PEG and HAp particles were prepared to examine cell adhesion in vitro using rat primary cultured osteoblast. Cells were observed to attach well on a PRX-HAp that have the same weight ratio of the polyrotaxane and HAp particles at 7 days after seeding. These results indicate that HAp particles are necessary for cell adhesion and survival, but a higher ratio of the particles is not suitable for cell adhesion. The composites of rat osteoblast and the PRX-HAp were implanted subcutaneously in syngeneic rats and harvested at 5 weeks after implantation. In histological analysis, osteoblast-like cells became arrayed along the surface of the PRX-HAp, and osteoid-like tissues were observed in the region between a queue of osteoblast-like cells and PRX-HAp. These images are similar to intramembranous ossification, and it is expected that bone regeneration occurs on the surface of the PRX-HAp. This study strongly suggests the great potential of the PRX-HAp as scaffolds for bone regeneration. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Poly(ethylene glycol) hydrogels cross-linked by hydrolyzable polyrotaxane containing hydroxyapatite particles as scaffolds for bone regeneration. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fujimoto%2C+Mariko%22">Fujimoto, Mariko</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Isobe%2C+Masatsugu%22">Isobe, Masatsugu</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Yamaguchi%2C+Satoshi%22">Yamaguchi, Satoshi</searchLink><relatesTo>1</relatesTo><i> yamachan.mfs@tmd.ac.jp</i><br /><searchLink fieldCode="AR" term="%22Amagasa%2C+Teruo%22">Amagasa, Teruo</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Watanabe%2C+Akihiko%22">Watanabe, Akihiko</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ooya%2C+Tooru%22">Ooya, Tooru</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Yui%2C+Nobuhiko%22">Yui, Nobuhiko</searchLink><relatesTo>3</relatesTo><i> yui@jaist.ac.jp</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Biomaterials+Science+--+Polymer+Edition%22">Journal of Biomaterials Science -- Polymer Edition</searchLink>. Dec2005, Vol. 16 Issue 12, p1611-1621. 11p. 5 Diagrams, 1 Chart, 1 Graph. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22BONE+regeneration%22">BONE regeneration</searchLink><br />*<searchLink fieldCode="DE" term="%22POLYETHYLENE+glycol%22">POLYETHYLENE glycol</searchLink><br />*<searchLink fieldCode="DE" term="%22HYDROGELS%22">HYDROGELS</searchLink><br />*<searchLink fieldCode="DE" term="%22HYDROXYAPATITE%22">HYDROXYAPATITE</searchLink><br />*<searchLink fieldCode="DE" term="%22CELL+adhesion%22">CELL adhesion</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Poly(ethylene glycol) (PEG) hydrogels cross-linked by a hydrolyzable polyrotaxane containing hydroxyapatite particles (PRX-HAp) were developed as scaffolds for bone regeneration. Five scaffolds with various composition of the polyrotaxane, PEG and HAp particles were prepared to examine cell adhesion in vitro using rat primary cultured osteoblast. Cells were observed to attach well on a PRX-HAp that have the same weight ratio of the polyrotaxane and HAp particles at 7 days after seeding. These results indicate that HAp particles are necessary for cell adhesion and survival, but a higher ratio of the particles is not suitable for cell adhesion. The composites of rat osteoblast and the PRX-HAp were implanted subcutaneously in syngeneic rats and harvested at 5 weeks after implantation. In histological analysis, osteoblast-like cells became arrayed along the surface of the PRX-HAp, and osteoid-like tissues were observed in the region between a queue of osteoblast-like cells and PRX-HAp. These images are similar to intramembranous ossification, and it is expected that bone regeneration occurs on the surface of the PRX-HAp. This study strongly suggests the great potential of the PRX-HAp as scaffolds for bone regeneration. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Biomaterials Science -- Polymer Edition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1163/156856205774576664 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1611 Subjects: – SubjectFull: BONE regeneration Type: general – SubjectFull: POLYETHYLENE glycol Type: general – SubjectFull: HYDROGELS Type: general – SubjectFull: HYDROXYAPATITE Type: general – SubjectFull: CELL adhesion Type: general Titles: – TitleFull: Poly(ethylene glycol) hydrogels cross-linked by hydrolyzable polyrotaxane containing hydroxyapatite particles as scaffolds for bone regeneration. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fujimoto, Mariko – PersonEntity: Name: NameFull: Isobe, Masatsugu – PersonEntity: Name: NameFull: Yamaguchi, Satoshi – PersonEntity: Name: NameFull: Amagasa, Teruo – PersonEntity: Name: NameFull: Watanabe, Akihiko – PersonEntity: Name: NameFull: Ooya, Tooru – PersonEntity: Name: NameFull: Yui, Nobuhiko IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2005 Type: published Y: 2005 Identifiers: – Type: issn-print Value: 09205063 Numbering: – Type: volume Value: 16 – Type: issue Value: 12 Titles: – TitleFull: Journal of Biomaterials Science -- Polymer Edition Type: main |
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