Prevalence and Misperception: Exploring the Gap Between Objective and Subjective Assessment of Sleep Apnea in a Population at Increased Risk for Dementia.
| Title: | Prevalence and Misperception: Exploring the Gap Between Objective and Subjective Assessment of Sleep Apnea in a Population at Increased Risk for Dementia. |
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| Authors: | Altuna, Miren1,2 (AUTHOR) maltuna@cita-alzheimer.org, García-Sebastián, Maite1,2 (AUTHOR), Ecay-Torres, Mirian1,3 (AUTHOR), Saldias, Jon1 (AUTHOR), Cañada, Marta1,2 (AUTHOR), Estanga, Ainara1,3 (AUTHOR), López, Carolina1 (AUTHOR), Tainta, Mikel3 (AUTHOR), Iriondo, Ane1 (AUTHOR), Arriba, Maria1 (AUTHOR), Ros, Naia1 (AUTHOR), Martínez-Lage, Pablo1 (AUTHOR) |
| Source: | Journal of Clinical Medicine. Apr2025, Vol. 14 Issue 8, p2607. 19p. |
| Abstract: | Background: Aging is a well-established independent risk factor for both cognitive impairment and sleep disorders, including obstructive sleep apnea (OSA), a modifiable yet underrecognized condition. OSA has been implicated in biological mechanisms contributing to Alzheimer's disease, including amyloid-β accumulation, tau phosphorylation, and neuroinflammation. This underscores the need to optimize OSA diagnosis in individuals with an increased risk of dementia. Methods: This cross-sectional observational study enrolled adults aged 60–85 years with a CAIDE dementia risk score ≥6. Subjective sleep was evaluated using validated questionnaires (Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, and the Oviedo Sleep Questionnaire), while objective sleep data were obtained through a single-night peripheral arterial tonometry (PAT)-based wearable device, complemented by a 7-day sleep diary. Participants also completed the STOP-BANG and Berlin questionnaires, with clinically relevant findings communicated to participants. Results: Among 322 participants (48.8% women; mean age 71.4 ± 6.4 years), moderate-to-severe OSA (apnea–hypopnea index [AHI] ≥ 15) was identified in 48.49%, despite the absence of prior diagnoses. Subjective screening tools frequently underestimated OSA severity compared to objective assessments. While no significant sex-based differences were noted, higher AHI values correlated strongly with increased body mass index and elevated dementia risk scores. Conclusions: A marked discrepancy between subjective and objective sleep measurements complicates the accurate diagnosis and management of most sleep disorders, including OSA. Sleep disorders remain significantly underdiagnosed in individuals at increased risk for dementia. Integrating wearable technologies and structured tools such as sleep diaries into routine assessments can enhance diagnostic precision, enabling timely interventions for these modifiable risk factors of dementia. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Prevalence and Misperception: Exploring the Gap Between Objective and Subjective Assessment of Sleep Apnea in a Population at Increased Risk for Dementia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Altuna%2C+Miren%22">Altuna, Miren</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> maltuna@cita-alzheimer.org</i><br /><searchLink fieldCode="AR" term="%22García-Sebastián%2C+Maite%22">García-Sebastián, Maite</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ecay-Torres%2C+Mirian%22">Ecay-Torres, Mirian</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Saldias%2C+Jon%22">Saldias, Jon</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cañada%2C+Marta%22">Cañada, Marta</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Estanga%2C+Ainara%22">Estanga, Ainara</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22López%2C+Carolina%22">López, Carolina</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tainta%2C+Mikel%22">Tainta, Mikel</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Iriondo%2C+Ane%22">Iriondo, Ane</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arriba%2C+Maria%22">Arriba, Maria</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ros%2C+Naia%22">Ros, Naia</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martínez-Lage%2C+Pablo%22">Martínez-Lage, Pablo</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Clinical+Medicine%22">Journal of Clinical Medicine</searchLink>. Apr2025, Vol. 14 Issue 8, p2607. 19p. – Name: Abstract Label: Abstract Group: Ab Data: Background: Aging is a well-established independent risk factor for both cognitive impairment and sleep disorders, including obstructive sleep apnea (OSA), a modifiable yet underrecognized condition. OSA has been implicated in biological mechanisms contributing to Alzheimer's disease, including amyloid-β accumulation, tau phosphorylation, and neuroinflammation. This underscores the need to optimize OSA diagnosis in individuals with an increased risk of dementia. Methods: This cross-sectional observational study enrolled adults aged 60–85 years with a CAIDE dementia risk score ≥6. Subjective sleep was evaluated using validated questionnaires (Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, and the Oviedo Sleep Questionnaire), while objective sleep data were obtained through a single-night peripheral arterial tonometry (PAT)-based wearable device, complemented by a 7-day sleep diary. Participants also completed the STOP-BANG and Berlin questionnaires, with clinically relevant findings communicated to participants. Results: Among 322 participants (48.8% women; mean age 71.4 ± 6.4 years), moderate-to-severe OSA (apnea–hypopnea index [AHI] ≥ 15) was identified in 48.49%, despite the absence of prior diagnoses. Subjective screening tools frequently underestimated OSA severity compared to objective assessments. While no significant sex-based differences were noted, higher AHI values correlated strongly with increased body mass index and elevated dementia risk scores. Conclusions: A marked discrepancy between subjective and objective sleep measurements complicates the accurate diagnosis and management of most sleep disorders, including OSA. Sleep disorders remain significantly underdiagnosed in individuals at increased risk for dementia. Integrating wearable technologies and structured tools such as sleep diaries into routine assessments can enhance diagnostic precision, enabling timely interventions for these modifiable risk factors of dementia. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Clinical Medicine is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/jcm14082607 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 19 StartPage: 2607 Titles: – TitleFull: Prevalence and Misperception: Exploring the Gap Between Objective and Subjective Assessment of Sleep Apnea in a Population at Increased Risk for Dementia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Altuna, Miren – PersonEntity: Name: NameFull: García-Sebastián, Maite – PersonEntity: Name: NameFull: Ecay-Torres, Mirian – PersonEntity: Name: NameFull: Saldias, Jon – PersonEntity: Name: NameFull: Cañada, Marta – PersonEntity: Name: NameFull: Estanga, Ainara – PersonEntity: Name: NameFull: López, Carolina – PersonEntity: Name: NameFull: Tainta, Mikel – PersonEntity: Name: NameFull: Iriondo, Ane – PersonEntity: Name: NameFull: Arriba, Maria – PersonEntity: Name: NameFull: Ros, Naia – PersonEntity: Name: NameFull: Martínez-Lage, Pablo IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 04 Text: Apr2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 20770383 Numbering: – Type: volume Value: 14 – Type: issue Value: 8 Titles: – TitleFull: Journal of Clinical Medicine Type: main |
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