Bibliographic Details
| Title: |
Leukocyte telomere length change in children with obesity in the context of an isocaloric fructose restriction intervention. |
| Authors: |
Wojcicki, Janet M.1 (AUTHOR) Janet.wojcicki@ucsf.edu, Epel, Elissa2 (AUTHOR), Lin, Jue3 (AUTHOR), Tai, Viva4 (AUTHOR), Schwarz, Jean-Marc5 (AUTHOR), Noworolski, Susan M.6 (AUTHOR), Erkin-Cakmak, Ayca7 (AUTHOR), Mulligan, Kathleen4,8 (AUTHOR), Gugliucci, Alejandro8 (AUTHOR), Lustig, Rob H.7 (AUTHOR) |
| Source: |
Diabetology & Metabolic Syndrome. 3/22/2025, Vol. 17 Issue 1, p1-6. 6p. |
| Subject Terms: |
*HISPANIC American children, *BLACK children, *REACTIVE oxygen species, *CHILDHOOD obesity, *HDL cholesterol |
| Abstract: |
Background: Few studies have evaluated changes in leukocyte telomere length (LTL) over a short time period (e.g. 1 week). LTL shortening is accelerated by exposure to inflammation and reactive oxygen species (ROS) damage. Methods: In the context of an isocaloric fructose restriction study that was conducted with 43 Black and Latinx children over a 9-day period, we evaluated the relationship between metabolic health at baseline and metabolic changes and LTL at baseline and %LTL change over the follow-up period. Linear regression models were used to assess associations between metabolic correlates and LTL at baseline and LTL changes over 9 days. Results: Overall children lost − 0.05 ± 0.14 T/S units or − 2.98 ± 8.74% total change over the follow-up period. Higher concentrations of HDL-C, APO-AI and a greater % of large HDL-C at baseline were associated with reduced LTL attrition rates at day 10 (p < 0.01; p < 0.01 and p = 0.02 respectively). Increases in APO-AI over the follow-up period were associated with increased LTL attrition over the follow-up period (p = 0.03). Conclusions: In this short term isocaloric fructose restriction study, LTL at baseline and changes in LTL over 9 days were associated with HDL-C and APO-AI and not with any other non-HDL-C lipids. Additional, larger studies are necessary to better understand the interplay between short term fructose restriction, LTL changes and HDL-C/APO-AI. [ABSTRACT FROM AUTHOR] |
|
Copyright of Diabetology & Metabolic Syndrome is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
