Association between exposure to volatile organic compounds and atherogenic index of plasma in NHANES 2011–2018.
| Title: | Association between exposure to volatile organic compounds and atherogenic index of plasma in NHANES 2011–2018. |
|---|---|
| Authors: | Meng, Lidian1 (AUTHOR), Wang, Yuqing1 (AUTHOR), Wang, Xisheng1 (AUTHOR), Mu, Menghui1 (AUTHOR), Zheng, He1 (AUTHOR) 303820823@qq.com |
| Source: | Scientific Reports. 3/16/2025, Vol. 15 Issue 1, p1-14. 14p. |
| Subject Terms: | *NATIONAL Health & Nutrition Examination Survey, *HDL cholesterol, *VOLATILE organic compounds, *QUANTILE regression, *MANN Whitney U Test |
| Abstract: | Volatile organic compounds (VOCs) are prevalent in daily life, yet the relationship between VOCs exposure and the atherogenic index of plasma (AIP) remains inadequately explored, especially in populations with high levels of exposure. This study aims to investigate the non-linear association between VOCs exposure and AIP in the U.S. adult population. Data from the National Health and Nutrition Examination Survey (NHANES) collected between 2011 and 2018 were analyzed. A range of statistical techniques, including Spearman's correlation analysis, weighted quantile sum (WQS), multivariate logistic regression, restricted cubic splines (RCS), stratified threshold models, and bayesian kernel machine regression (BKMR), were systematically employed to assess the relationship between high-dose VOCs exposure and AIP in U.S. adults. The study included 6,027 participants, with an average age of 37 (18–59), and 50.46% were male. Of these, 3,011 had elevated AIP levels. The Mann-Whitney U test compared VOCs exposure across quartiles (Q1–Q4). Spearman models revealed strong joint exposure effects between VOCs like IPMA3 and HMPMA (ρ = 0.97). WQS regression showed a positive association between VOCs and total cholesterol (TC) (β = 5.45, 95% CI = 5.42–5.58, P = 0.04) and high-density lipoprotein cholesterol (HDL-C) (β = 1.07, 95% CI = 1.03–1.10, P = 0.02). After adjusting for confounders, logistic regression revealed that VOCs such as 3-4MHA, 34DMA, AAMA, ATCA, CYMA, HEMA, and SBMA were linked to higher AIP. RCS analysis indicated a nonlinear association between VOCs and AIP. Stratified modeling found that ATCA was significantly and positively associated with AIP (OR = 1.60, 95% CI = 1.20–2.14, p < 0.01), and that when ATCA levels exceeded 128.60 ng/mL, there was a 60% increased risk of elevated AIP. Higher urinary VOCs levels, particularly ATCA, are significantly associated with increased AIP, offering new insights into the potential link between VOCs exposure and cardiovascular disease. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Association between exposure to volatile organic compounds and atherogenic index of plasma in NHANES 2011–2018. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Meng%2C+Lidian%22">Meng, Lidian</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Yuqing%22">Wang, Yuqing</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Xisheng%22">Wang, Xisheng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mu%2C+Menghui%22">Mu, Menghui</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zheng%2C+He%22">Zheng, He</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> 303820823@qq.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Scientific+Reports%22">Scientific Reports</searchLink>. 3/16/2025, Vol. 15 Issue 1, p1-14. 14p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22NATIONAL+Health+%26+Nutrition+Examination+Survey%22">NATIONAL Health & Nutrition Examination Survey</searchLink><br />*<searchLink fieldCode="DE" term="%22HDL+cholesterol%22">HDL cholesterol</searchLink><br />*<searchLink fieldCode="DE" term="%22VOLATILE+organic+compounds%22">VOLATILE organic compounds</searchLink><br />*<searchLink fieldCode="DE" term="%22QUANTILE+regression%22">QUANTILE regression</searchLink><br />*<searchLink fieldCode="DE" term="%22MANN+Whitney+U+Test%22">MANN Whitney U Test</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Volatile organic compounds (VOCs) are prevalent in daily life, yet the relationship between VOCs exposure and the atherogenic index of plasma (AIP) remains inadequately explored, especially in populations with high levels of exposure. This study aims to investigate the non-linear association between VOCs exposure and AIP in the U.S. adult population. Data from the National Health and Nutrition Examination Survey (NHANES) collected between 2011 and 2018 were analyzed. A range of statistical techniques, including Spearman's correlation analysis, weighted quantile sum (WQS), multivariate logistic regression, restricted cubic splines (RCS), stratified threshold models, and bayesian kernel machine regression (BKMR), were systematically employed to assess the relationship between high-dose VOCs exposure and AIP in U.S. adults. The study included 6,027 participants, with an average age of 37 (18–59), and 50.46% were male. Of these, 3,011 had elevated AIP levels. The Mann-Whitney U test compared VOCs exposure across quartiles (Q1–Q4). Spearman models revealed strong joint exposure effects between VOCs like IPMA3 and HMPMA (ρ = 0.97). WQS regression showed a positive association between VOCs and total cholesterol (TC) (β = 5.45, 95% CI = 5.42–5.58, P = 0.04) and high-density lipoprotein cholesterol (HDL-C) (β = 1.07, 95% CI = 1.03–1.10, P = 0.02). After adjusting for confounders, logistic regression revealed that VOCs such as 3-4MHA, 34DMA, AAMA, ATCA, CYMA, HEMA, and SBMA were linked to higher AIP. RCS analysis indicated a nonlinear association between VOCs and AIP. Stratified modeling found that ATCA was significantly and positively associated with AIP (OR = 1.60, 95% CI = 1.20–2.14, p < 0.01), and that when ATCA levels exceeded 128.60 ng/mL, there was a 60% increased risk of elevated AIP. Higher urinary VOCs levels, particularly ATCA, are significantly associated with increased AIP, offering new insights into the potential link between VOCs exposure and cardiovascular disease. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41598-025-93833-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 1 Subjects: – SubjectFull: NATIONAL Health & Nutrition Examination Survey Type: general – SubjectFull: HDL cholesterol Type: general – SubjectFull: VOLATILE organic compounds Type: general – SubjectFull: QUANTILE regression Type: general – SubjectFull: MANN Whitney U Test Type: general Titles: – TitleFull: Association between exposure to volatile organic compounds and atherogenic index of plasma in NHANES 2011–2018. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Meng, Lidian – PersonEntity: Name: NameFull: Wang, Yuqing – PersonEntity: Name: NameFull: Wang, Xisheng – PersonEntity: Name: NameFull: Mu, Menghui – PersonEntity: Name: NameFull: Zheng, He IsPartOfRelationships: – BibEntity: Dates: – D: 16 M: 03 Text: 3/16/2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 20452322 Numbering: – Type: volume Value: 15 – Type: issue Value: 1 Titles: – TitleFull: Scientific Reports Type: main |
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