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Aspartic acid functionalized magnetic nanoparticles for enhanced internalization in tumoral cell.

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Title: Aspartic acid functionalized magnetic nanoparticles for enhanced internalization in tumoral cell.
Authors: Motelica, Ludmila1,2,3 (AUTHOR) ludmila.motelica@upb.ro, Voicu, Geanina4 (AUTHOR) geanina.voicu@icbp.ro, Chircov, Cristina1,5 (AUTHOR) cristina.chircov@upb.ro, Surdu, Adrian Vasile1,5 (AUTHOR), Trusca, Roxana Doina1 (AUTHOR) roxana_doina.trusca@upb.ro, Vasile, Bogdan Stefan1,2,3 (AUTHOR) bogdan.vasile@upb.ro, Ficai, Denisa1,2,6 (AUTHOR) denisa.ficai@upb.ro, Oprea, Ovidiu Cristian1,2,6 (AUTHOR) ovidiu.oprea@upb.ro, Marta, Daciana Silvia7 (AUTHOR) daciana.marta@ivb.ro, Peteu, Victor-Eduard7,8 (AUTHOR) peteuvictoreduard@gmail.com, Anghelache, Maria4 (AUTHOR) anghelache.maria@icbp.ro, Ficai, Anton1,2,5 (AUTHOR) anton.ficai@upb.ro, Calin, Manuela4 (AUTHOR) manuela.calin@icbp.ro
Source: Journal of the Australian Ceramic Society. Mar2025, Vol. 61 Issue 1, p265-283. 19p.
Abstract: The antitumoral activity, and in general, the biological activity is strongly altered by the low uptake of the active agents within the targeted cells. Therefore, lots of efforts have been made to ensure better cellular uptake by using specific carriers. In the present research we have obtained magnetic nanoparticles stabilized by polyethylene glycol (PEG) coating, and functionalized with aspartic acid, which is an important amino acid for protein synthesis and energy production in the body. Such decorated nanoparticles can be internalized by the tumoral cell due to their higher metabolic rate. The nanoparticles were used as a delivery system for antitumoral drugs as cisplatin, carboplatin or irinotecan in a Trojan Horse strategy. Based on the obtained results, it was found that aspartic acid can improve the internalization efficiency of the magnetic carriers after being loaded with antitumoral agents. The nanoparticles are quite stable, can reach and enter the mitochondria and organize around lipid vesicles in quite a high concentration, best results being obtained for the system loaded with cisplatin starting from 0.1 mg/mL. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the Australian Ceramic Society is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Aspartic acid functionalized magnetic nanoparticles for enhanced internalization in tumoral cell.
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+the+Australian+Ceramic+Society%22">Journal of the Australian Ceramic Society</searchLink>. Mar2025, Vol. 61 Issue 1, p265-283. 19p.
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  Label: Abstract
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  Data: The antitumoral activity, and in general, the biological activity is strongly altered by the low uptake of the active agents within the targeted cells. Therefore, lots of efforts have been made to ensure better cellular uptake by using specific carriers. In the present research we have obtained magnetic nanoparticles stabilized by polyethylene glycol (PEG) coating, and functionalized with aspartic acid, which is an important amino acid for protein synthesis and energy production in the body. Such decorated nanoparticles can be internalized by the tumoral cell due to their higher metabolic rate. The nanoparticles were used as a delivery system for antitumoral drugs as cisplatin, carboplatin or irinotecan in a Trojan Horse strategy. Based on the obtained results, it was found that aspartic acid can improve the internalization efficiency of the magnetic carriers after being loaded with antitumoral agents. The nanoparticles are quite stable, can reach and enter the mitochondria and organize around lipid vesicles in quite a high concentration, best results being obtained for the system loaded with cisplatin starting from 0.1 mg/mL. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of the Australian Ceramic Society is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s41779-024-01102-x
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        Text: English
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              Text: Mar2025
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