Academic Journal
View in EDS
HTML Full Text

The Promise of Radiotherapy in High-Risk Non-Muscle Invasive Bladder Cancer.

Bibliographic Details
Title: The Promise of Radiotherapy in High-Risk Non-Muscle Invasive Bladder Cancer.
Authors: Bola, Becky1,2 (AUTHOR), Hoskin, Peter J.3,4 (AUTHOR), Sangar, Vijay2,5 (AUTHOR), Choudhury, Ananya3,4 (AUTHOR) ananya.choudhury@nhs.net
Source: Cancers. Feb2025, Vol. 17 Issue 4, p628. 14p.
Subject Terms: *NON-muscle invasive bladder cancer, *DRUG toxicity, *RADIOTHERAPY, *DIFFUSION of innovations, *TERMINATION of treatment, *BCG vaccines, *MEDICAL care, *INVENTORY shortages, *TUMOR markers, *RADIATION-sensitizing agents, *DNA damage, *COMBINED modality therapy, *DRUGS
Abstract: Simple Summary: Non-muscle invasive bladder cancer (NMIBC) is not currently treated with radiotherapy. However, other bladder cancers are successfully treated with radiotherapy. In this review, we discuss how NMIBC is treated currently and what the advantages and disadvantages of these treatments are. We summarise the recent developments in the treatment of NMIBC and highlight the promise of radiotherapy in this context. We then discuss future treatments for non-muscle invasive bladder cancer and how existing treatments can be made more effective. Global shortages, toxicities, and high levels of incomplete treatment with Bacillus Calmette Guerin (BCG) for non-muscle invasive bladder cancer has resulted in increasing interest in alternative treatments. Radiotherapy is not the standard of care for non-muscle invasive bladder cancer (NMIBC), despite being routinely used in muscle invasive bladder cancer. Modern techniques and advances in technology mean that radiotherapy can be delivered with increased precision in reducing normal tissue damage. Developing novel biomarker approaches, together with combination approaches with radiosensitisers and other systemic treatments, means that radiotherapy could offer greater benefits than current treatments with BCG or surgery. This review summarises the current landscape and future potential of radiotherapy for high-risk NMIBC. [ABSTRACT FROM AUTHOR]
Copyright of Cancers is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Academic Search Complete
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:a9h&genre=article&issn=20726694&ISBN=&volume=17&issue=4&date=20250215&spage=628&pages=628-641&title=Cancers&atitle=The%20Promise%20of%20Radiotherapy%20in%20High-Risk%20Non-Muscle%20Invasive%20Bladder%20Cancer.&aulast=Bola%2C%20Becky&id=DOI:10.3390/cancers17040628
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: a9h
DbLabel: Academic Search Complete
An: 183336391
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: The Promise of Radiotherapy in High-Risk Non-Muscle Invasive Bladder Cancer.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Bola%2C+Becky%22">Bola, Becky</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hoskin%2C+Peter+J%2E%22">Hoskin, Peter J.</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sangar%2C+Vijay%22">Sangar, Vijay</searchLink><relatesTo>2,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Choudhury%2C+Ananya%22">Choudhury, Ananya</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<i> ananya.choudhury@nhs.net</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Cancers%22">Cancers</searchLink>. Feb2025, Vol. 17 Issue 4, p628. 14p.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22NON-muscle+invasive+bladder+cancer%22">NON-muscle invasive bladder cancer</searchLink><br />*<searchLink fieldCode="DE" term="%22DRUG+toxicity%22">DRUG toxicity</searchLink><br />*<searchLink fieldCode="DE" term="%22RADIOTHERAPY%22">RADIOTHERAPY</searchLink><br />*<searchLink fieldCode="DE" term="%22DIFFUSION+of+innovations%22">DIFFUSION of innovations</searchLink><br />*<searchLink fieldCode="DE" term="%22TERMINATION+of+treatment%22">TERMINATION of treatment</searchLink><br />*<searchLink fieldCode="DE" term="%22BCG+vaccines%22">BCG vaccines</searchLink><br />*<searchLink fieldCode="DE" term="%22MEDICAL+care%22">MEDICAL care</searchLink><br />*<searchLink fieldCode="DE" term="%22INVENTORY+shortages%22">INVENTORY shortages</searchLink><br />*<searchLink fieldCode="DE" term="%22TUMOR+markers%22">TUMOR markers</searchLink><br />*<searchLink fieldCode="DE" term="%22RADIATION-sensitizing+agents%22">RADIATION-sensitizing agents</searchLink><br />*<searchLink fieldCode="DE" term="%22DNA+damage%22">DNA damage</searchLink><br />*<searchLink fieldCode="DE" term="%22COMBINED+modality+therapy%22">COMBINED modality therapy</searchLink><br />*<searchLink fieldCode="DE" term="%22DRUGS%22">DRUGS</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Simple Summary: Non-muscle invasive bladder cancer (NMIBC) is not currently treated with radiotherapy. However, other bladder cancers are successfully treated with radiotherapy. In this review, we discuss how NMIBC is treated currently and what the advantages and disadvantages of these treatments are. We summarise the recent developments in the treatment of NMIBC and highlight the promise of radiotherapy in this context. We then discuss future treatments for non-muscle invasive bladder cancer and how existing treatments can be made more effective. Global shortages, toxicities, and high levels of incomplete treatment with Bacillus Calmette Guerin (BCG) for non-muscle invasive bladder cancer has resulted in increasing interest in alternative treatments. Radiotherapy is not the standard of care for non-muscle invasive bladder cancer (NMIBC), despite being routinely used in muscle invasive bladder cancer. Modern techniques and advances in technology mean that radiotherapy can be delivered with increased precision in reducing normal tissue damage. Developing novel biomarker approaches, together with combination approaches with radiosensitisers and other systemic treatments, means that radiotherapy could offer greater benefits than current treatments with BCG or surgery. This review summarises the current landscape and future potential of radiotherapy for high-risk NMIBC. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Cancers is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=a9h&AN=183336391
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3390/cancers17040628
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 628
    Subjects:
      – SubjectFull: NON-muscle invasive bladder cancer
        Type: general
      – SubjectFull: DRUG toxicity
        Type: general
      – SubjectFull: RADIOTHERAPY
        Type: general
      – SubjectFull: DIFFUSION of innovations
        Type: general
      – SubjectFull: TERMINATION of treatment
        Type: general
      – SubjectFull: BCG vaccines
        Type: general
      – SubjectFull: MEDICAL care
        Type: general
      – SubjectFull: INVENTORY shortages
        Type: general
      – SubjectFull: TUMOR markers
        Type: general
      – SubjectFull: RADIATION-sensitizing agents
        Type: general
      – SubjectFull: DNA damage
        Type: general
      – SubjectFull: COMBINED modality therapy
        Type: general
      – SubjectFull: DRUGS
        Type: general
    Titles:
      – TitleFull: The Promise of Radiotherapy in High-Risk Non-Muscle Invasive Bladder Cancer.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Bola, Becky
      – PersonEntity:
          Name:
            NameFull: Hoskin, Peter J.
      – PersonEntity:
          Name:
            NameFull: Sangar, Vijay
      – PersonEntity:
          Name:
            NameFull: Choudhury, Ananya
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 02
              Text: Feb2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 20726694
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Cancers
              Type: main
ResultId 1