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Safety and Efficacy in the Transcortical and Transsylvian Approach in Insular High-Grade Gliomas: A Comparative Series of 58 Patients.

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Title: Safety and Efficacy in the Transcortical and Transsylvian Approach in Insular High-Grade Gliomas: A Comparative Series of 58 Patients.
Authors: Morello, Alberto1 (AUTHOR) alberto.morello@unito.it, Rizzo, Francesca1,2 (AUTHOR), Gatto, Andrea1,3 (AUTHOR), Panico, Flavio1,4 (AUTHOR), Bianconi, Andrea2,5 (AUTHOR), Chiari, Giulia3,6 (AUTHOR), Armocida, Daniele4,7 (AUTHOR), Greco Crasto, Stefania5,8 (AUTHOR), Melcarne, Antonio1 (AUTHOR), Zenga, Francesco1,6 (AUTHOR), Rudà, Roberta7 (AUTHOR), Morana, Giovanni8 (AUTHOR), Garbossa, Diego1 (AUTHOR), Cofano, Fabio1 (AUTHOR)
Source: Current Oncology. Feb2025, Vol. 32 Issue 2, p98. 13p.
Subject Terms: *GLIOMAS, *INSULAR cortex, *PROGNOSIS, *OPERATIVE surgery, *TREATMENT effectiveness, *NEUROSURGERY, TUMOR surgery
Abstract: Gliomas within the insular region represent one of the most challenging problems in neurosurgical oncology. There are two main surgical approaches to address the complex vascular network and functional areas around the insula: the transsylvian approach and the transcortical approach. In the literature, there is not a clear consensus on the best approach in terms of safety and efficacy. The purpose of this study is to evaluate the effectiveness of these approaches and to analyze prognostic factors on the natural history of insular gliomas. Patients with newly diagnosed high-grade insular gliomas who underwent surgery between January 2019 and June 2024 were analyzed. The series was analyzed according to the classification of Berger–Sanai and Yaşargil. The Karnofsky performance score (KPS), extent of resection (EOR), progression-free survival (PFS), and overall survival (OS) were considered the outcome measures. A total of 58 primary high-grade insular glioma patients were enrolled in this study. The IDH mutation was found in 13/58 (22.4%); specifically, 3/13 (23.1%) were grade 4, and 10/13 (76.9%) were grade 3. Furthermore, 40/58 patients (69%) underwent gross total resection (GTR), 15 patients (26%) subtotal resection, and 3 patients (5%) partial resection. Middle cerebral artery encasement negatively affected the OS. GTR, radiotherapy, KPS, and autonomous deambulation at a month after surgery positively affected the OS. The surgical approach used was transsylvian and transcortical in 11 and 47 cases, respectively. The comparison between the two different approaches did not display differences in terms of neurological deficits and OS (p > 0.05). The transcortical approach was related to the greater achievement of GTR (p = 0.031). According to the Berger–Sanai classification, the transcortical approach has higher EOR and postoperative KPS when the lesion is in zone III-IV (p = 0.029). Greater resection of insular gliomas can be achieved with an acceptable morbidity profile and is predictive of improved OS. Both the transsylvian and transcortical corridors to the insula are associated with low morbidity profiles. The transcortical approach with intraoperative mapping is more favorable for achieving greater EOR, particularly in gliomas within the inferior border of the Sylvian fissure. [ABSTRACT FROM AUTHOR]
Copyright of Current Oncology is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Safety and Efficacy in the Transcortical and Transsylvian Approach in Insular High-Grade Gliomas: A Comparative Series of 58 Patients.
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  Data: <searchLink fieldCode="AR" term="%22Morello%2C+Alberto%22">Morello, Alberto</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> alberto.morello@unito.it</i><br /><searchLink fieldCode="AR" term="%22Rizzo%2C+Francesca%22">Rizzo, Francesca</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gatto%2C+Andrea%22">Gatto, Andrea</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Panico%2C+Flavio%22">Panico, Flavio</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bianconi%2C+Andrea%22">Bianconi, Andrea</searchLink><relatesTo>2,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chiari%2C+Giulia%22">Chiari, Giulia</searchLink><relatesTo>3,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Armocida%2C+Daniele%22">Armocida, Daniele</searchLink><relatesTo>4,7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Greco+Crasto%2C+Stefania%22">Greco Crasto, Stefania</searchLink><relatesTo>5,8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Melcarne%2C+Antonio%22">Melcarne, Antonio</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zenga%2C+Francesco%22">Zenga, Francesco</searchLink><relatesTo>1,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rudà%2C+Roberta%22">Rudà, Roberta</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Morana%2C+Giovanni%22">Morana, Giovanni</searchLink><relatesTo>8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garbossa%2C+Diego%22">Garbossa, Diego</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cofano%2C+Fabio%22">Cofano, Fabio</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Current+Oncology%22">Current Oncology</searchLink>. Feb2025, Vol. 32 Issue 2, p98. 13p.
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  Data: *<searchLink fieldCode="DE" term="%22GLIOMAS%22">GLIOMAS</searchLink><br />*<searchLink fieldCode="DE" term="%22INSULAR+cortex%22">INSULAR cortex</searchLink><br />*<searchLink fieldCode="DE" term="%22PROGNOSIS%22">PROGNOSIS</searchLink><br />*<searchLink fieldCode="DE" term="%22OPERATIVE+surgery%22">OPERATIVE surgery</searchLink><br />*<searchLink fieldCode="DE" term="%22TREATMENT+effectiveness%22">TREATMENT effectiveness</searchLink><br />*<searchLink fieldCode="DE" term="%22NEUROSURGERY%22">NEUROSURGERY</searchLink><br /><searchLink fieldCode="DE" term="%22TUMOR+surgery%22">TUMOR surgery</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Gliomas within the insular region represent one of the most challenging problems in neurosurgical oncology. There are two main surgical approaches to address the complex vascular network and functional areas around the insula: the transsylvian approach and the transcortical approach. In the literature, there is not a clear consensus on the best approach in terms of safety and efficacy. The purpose of this study is to evaluate the effectiveness of these approaches and to analyze prognostic factors on the natural history of insular gliomas. Patients with newly diagnosed high-grade insular gliomas who underwent surgery between January 2019 and June 2024 were analyzed. The series was analyzed according to the classification of Berger–Sanai and Yaşargil. The Karnofsky performance score (KPS), extent of resection (EOR), progression-free survival (PFS), and overall survival (OS) were considered the outcome measures. A total of 58 primary high-grade insular glioma patients were enrolled in this study. The IDH mutation was found in 13/58 (22.4%); specifically, 3/13 (23.1%) were grade 4, and 10/13 (76.9%) were grade 3. Furthermore, 40/58 patients (69%) underwent gross total resection (GTR), 15 patients (26%) subtotal resection, and 3 patients (5%) partial resection. Middle cerebral artery encasement negatively affected the OS. GTR, radiotherapy, KPS, and autonomous deambulation at a month after surgery positively affected the OS. The surgical approach used was transsylvian and transcortical in 11 and 47 cases, respectively. The comparison between the two different approaches did not display differences in terms of neurological deficits and OS (p > 0.05). The transcortical approach was related to the greater achievement of GTR (p = 0.031). According to the Berger–Sanai classification, the transcortical approach has higher EOR and postoperative KPS when the lesion is in zone III-IV (p = 0.029). Greater resection of insular gliomas can be achieved with an acceptable morbidity profile and is predictive of improved OS. Both the transsylvian and transcortical corridors to the insula are associated with low morbidity profiles. The transcortical approach with intraoperative mapping is more favorable for achieving greater EOR, particularly in gliomas within the inferior border of the Sylvian fissure. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Current Oncology is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/curroncol32020098
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        Text: English
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      – SubjectFull: GLIOMAS
        Type: general
      – SubjectFull: INSULAR cortex
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      – SubjectFull: PROGNOSIS
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      – SubjectFull: OPERATIVE surgery
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      – SubjectFull: TREATMENT effectiveness
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              Text: Feb2025
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