Hemodynamic Improvements and Regression of Left Ventricular Hypertrophy Following Aortic Valve Replacement with Bioprosthetic Valves: A Prospective Study.
| Title: | Hemodynamic Improvements and Regression of Left Ventricular Hypertrophy Following Aortic Valve Replacement with Bioprosthetic Valves: A Prospective Study. |
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| Authors: | Kishore, B. Krishna1, Jarpula, Jampla1 drjampla@gmail.com |
| Source: | European Journal of Cardiovascular Medicine. Jan/Feb2025, Vol. 15 Issue 1, p282-292. 11p. |
| Subject Terms: | *BIOPROSTHETIC heart valves, *LEFT ventricular hypertrophy, *AORTIC stenosis, *AORTIC valve transplantation, *OLDER patients |
| Abstract: | Background: Aortic valve replacement (AVR) with bioprosthetic valves is a widely accepted treatment for severe aortic stenosis, particularly in elderly patients or those unable to tolerate lifelong anticoagulation. Bioprosthetic valves offer distinct advantages, including improved hemodynamics and reduced risks of thromboembolism. Objective: To evaluate hemodynamic improvements and regression of left ventricular hypertrophy in patients undergoing AVR with bioprosthetic valves, using echocardiographic parameters over a one-year follow-up period. Methods: This hospital-based prospective study included 100 patients with isolated severe aortic stenosis undergoing AVR with bioprosthetic valves at Narayana Hrudayalaya, Bangalore, from June 2011 to May 2015. Parameters such as left ventricular mass (LVM), left ventricular internal diameter in diastole and systole (LVIDD, LVIDS), and ejection fraction (EF) were assessed preoperatively and one year postoperatively. Statistical analysis was performed using paired t-tests for pre- and post-comparison. Results: The study population comprised 70 male and 30 female patients, with a mean age of 60.5 ± 9.3 years. Significant improvements were observed in LVM (mean reduction: 19%), LVIDD (8.7%), LVIDS (10%), and EF (3.7%) postoperatively. Hemodynamic parameters, such as peak pressure gradient (PPG) and mean pressure gradient (MPG), demonstrated significant reductions of 75.5% and 79.6%, respectively. Conclusion: AVR with bioprosthetic valves significantly improves hemodynamic parameters and leads to left ventricular mass regression, enhancing patients' clinical outcomes. The absence of thromboembolic or hemorrhagic events during follow-up underscores the safety and efficacy of bioprosthetic valves. [ABSTRACT FROM AUTHOR] |
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| Database: | Academic Search Complete |
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