Comparison of the Insertion Conditions and Haemodynamic Changes during I-Gel Insertion using Propofol, Ketamine-Propofol (Ketofol) and Thiopentone Intravenous Induction Agents: An Interventional Study.
| Title: | Comparison of the Insertion Conditions and Haemodynamic Changes during I-Gel Insertion using Propofol, Ketamine-Propofol (Ketofol) and Thiopentone Intravenous Induction Agents: An Interventional Study. |
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| Authors: | SHAH, POOJA ARPAN1, SURTI, AASHI NILESH2 ash18sut@gmail.com, KUMARI, ANUPAMA3, CHAUHAN, DINESH K.1, THOMAS, SARA MARY4 |
| Source: | Journal of Clinical & Diagnostic Research. Jan2025, Vol. 19 Issue 1, p29-33. 5p. |
| Subject Terms: | *LARYNGEAL masks, *CLINICAL trials, *VOCAL cords, *CHI-squared test, *KRUSKAL-Wallis Test |
| Abstract: | Introduction: The I-gel was designed to mitigate adverse reactions by providing the advantages of a secure airway without the complications associated with visualisation and tracheal intubation, specifically reducing the risk of barotrauma and vocal cord damage. Insertion requires a good induction agent and adequate depth of anaesthesia to achieve proper jaw relaxation and to prevent effects such as coughing, gagging, laryngospasm and any movements. Induction agents like propofol, ketamine and thiopentone have facilitated Laryngeal Mask Airway (LMA) insertion with ease. Aim: To compare insertion conditions and haemodynamic changes during I-gel insertion using propofol, ketamine-propofol (ketofol) and thiopentone as intravenous induction agents. Materials and Methods: An interventional study was conducted at a tertiary care hospital, Anaesthesiology Department of Dhiraj General Hospital in Piparia, Vadodara, Gujarat, India from August 1, 2023, to July 31, 2024. within one year after receiving ethical clearance from the institutional ethical committee. A total of 36 patients with American Society of Anaesthesiologists (ASA) physical status I and II, aged 18-60 years, were randomly divided into three groups. The induction agents administered before I-gel insertion for general anaesthesia in groups 1, 2 and 3 were propofol (2 mg/kg), ketofol (1 mg/kg ketamine and 1 mg/kg propofol) and thiopentone (4 mg/kg), respectively. Intubating conditions such as jaw mobility, number of attempts, ease of insertion, duration of insertion and haemodynamic response during I-gel insertion were recorded. The Kruskal-Wallis test and Chi-square test were used for quantitative and qualitative parameters, respectively. A p-value of =0.05 was considered statistically significant. Results: The mean age of Group-1, Group-2 and Group-3 was 34.67±5.97 years, 33.25±8.70 years and 36±8.48 years, respectively. Complete jaw relaxation and mouth opening were better in the ketofol group than in the propofol group (p-value: 0.003) and were significantly lower in the thiopentone group. Induction time was faster in the ketofol group than in the other groups. Patients in the ketofol and propofol groups exhibited better intubating conditions and preserved haemodynamics following I-gel insertion compared to those in the thiopentone group. Conclusion: Compared to propofol and thiopentone, ketofol demonstrated a faster onset of action and ensured better insertion conditions and greater haemodynamic stability, making it a preferred choice for I-gel insertion. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Comparison of the Insertion Conditions and Haemodynamic Changes during I-Gel Insertion using Propofol, Ketamine-Propofol (Ketofol) and Thiopentone Intravenous Induction Agents: An Interventional Study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22SHAH%2C+POOJA+ARPAN%22">SHAH, POOJA ARPAN</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22SURTI%2C+AASHI+NILESH%22">SURTI, AASHI NILESH</searchLink><relatesTo>2</relatesTo><i> ash18sut@gmail.com</i><br /><searchLink fieldCode="AR" term="%22KUMARI%2C+ANUPAMA%22">KUMARI, ANUPAMA</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22CHAUHAN%2C+DINESH+K%2E%22">CHAUHAN, DINESH K.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22THOMAS%2C+SARA+MARY%22">THOMAS, SARA MARY</searchLink><relatesTo>4</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Clinical+%26+Diagnostic+Research%22">Journal of Clinical & Diagnostic Research</searchLink>. Jan2025, Vol. 19 Issue 1, p29-33. 5p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22LARYNGEAL+masks%22">LARYNGEAL masks</searchLink><br />*<searchLink fieldCode="DE" term="%22CLINICAL+trials%22">CLINICAL trials</searchLink><br />*<searchLink fieldCode="DE" term="%22VOCAL+cords%22">VOCAL cords</searchLink><br />*<searchLink fieldCode="DE" term="%22CHI-squared+test%22">CHI-squared test</searchLink><br />*<searchLink fieldCode="DE" term="%22KRUSKAL-Wallis+Test%22">KRUSKAL-Wallis Test</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Introduction: The I-gel was designed to mitigate adverse reactions by providing the advantages of a secure airway without the complications associated with visualisation and tracheal intubation, specifically reducing the risk of barotrauma and vocal cord damage. Insertion requires a good induction agent and adequate depth of anaesthesia to achieve proper jaw relaxation and to prevent effects such as coughing, gagging, laryngospasm and any movements. Induction agents like propofol, ketamine and thiopentone have facilitated Laryngeal Mask Airway (LMA) insertion with ease. Aim: To compare insertion conditions and haemodynamic changes during I-gel insertion using propofol, ketamine-propofol (ketofol) and thiopentone as intravenous induction agents. Materials and Methods: An interventional study was conducted at a tertiary care hospital, Anaesthesiology Department of Dhiraj General Hospital in Piparia, Vadodara, Gujarat, India from August 1, 2023, to July 31, 2024. within one year after receiving ethical clearance from the institutional ethical committee. A total of 36 patients with American Society of Anaesthesiologists (ASA) physical status I and II, aged 18-60 years, were randomly divided into three groups. The induction agents administered before I-gel insertion for general anaesthesia in groups 1, 2 and 3 were propofol (2 mg/kg), ketofol (1 mg/kg ketamine and 1 mg/kg propofol) and thiopentone (4 mg/kg), respectively. Intubating conditions such as jaw mobility, number of attempts, ease of insertion, duration of insertion and haemodynamic response during I-gel insertion were recorded. The Kruskal-Wallis test and Chi-square test were used for quantitative and qualitative parameters, respectively. A p-value of =0.05 was considered statistically significant. Results: The mean age of Group-1, Group-2 and Group-3 was 34.67±5.97 years, 33.25±8.70 years and 36±8.48 years, respectively. Complete jaw relaxation and mouth opening were better in the ketofol group than in the propofol group (p-value: 0.003) and were significantly lower in the thiopentone group. Induction time was faster in the ketofol group than in the other groups. Patients in the ketofol and propofol groups exhibited better intubating conditions and preserved haemodynamics following I-gel insertion compared to those in the thiopentone group. Conclusion: Compared to propofol and thiopentone, ketofol demonstrated a faster onset of action and ensured better insertion conditions and greater haemodynamic stability, making it a preferred choice for I-gel insertion. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Clinical & Diagnostic Research is the property of JCDR Research & Publications Private Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.7860/JCDR/2025/75419.20488 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 29 Subjects: – SubjectFull: LARYNGEAL masks Type: general – SubjectFull: CLINICAL trials Type: general – SubjectFull: VOCAL cords Type: general – SubjectFull: CHI-squared test Type: general – SubjectFull: KRUSKAL-Wallis Test Type: general Titles: – TitleFull: Comparison of the Insertion Conditions and Haemodynamic Changes during I-Gel Insertion using Propofol, Ketamine-Propofol (Ketofol) and Thiopentone Intravenous Induction Agents: An Interventional Study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: SHAH, POOJA ARPAN – PersonEntity: Name: NameFull: SURTI, AASHI NILESH – PersonEntity: Name: NameFull: KUMARI, ANUPAMA – PersonEntity: Name: NameFull: CHAUHAN, DINESH K. – PersonEntity: Name: NameFull: THOMAS, SARA MARY IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 0973709X Numbering: – Type: volume Value: 19 – Type: issue Value: 1 Titles: – TitleFull: Journal of Clinical & Diagnostic Research Type: main |
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