Bibliographic Details
| Title: |
Relationship between insulin resistance surrogates and bone mineral density in postmenopausal women. |
| Authors: |
Li, Min1 (AUTHOR), Gao, Lei2 (AUTHOR), Liu, Ying2 (AUTHOR), Zheng, Yongli2 (AUTHOR), Chen, Luyao1 (AUTHOR), Wang, Yan1 (AUTHOR) wangyan66200@163.com, Zhang, Wei2 (AUTHOR) |
| Source: |
Climacteric. Apr2025, Vol. 28 Issue 2, p154-161. 8p. |
| Abstract (English): |
Objective: This study aimed to investigate the association between four insulin resistance (IR) surrogates and bone mineral density (BMD) and whether IR surrogates could be risk factors for osteoporosis (OP) in Chinese non-diabetic postmenopausal individuals. Methods: Four non-insulin-based surrogates including triglyceride glucose (TyG), triglyceride glucose with body mass index (TyG-BMI), triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C) and the metabolic score for insulin resistance (METS-IR) index were calculated. All individuals underwent dual-energy X-ray absorptiometry for measurement of BMD. Pearson correlation analysis was employed to evaluate the correlations between IR indices and BMD. Subsequently, logistic regression analysis was performed to investigate the relationship between these indices and OP while the receiver-operating characteristic curve was used to assess the predictive values for OP. Results: Both TyG-BMI and the METS-IR index were significantly positively associated with BMD. As TyG-BMI and the METS-IR index increased, the prevalence of OP decreased. After adjusting confounding factors, the fourth quartile of TyG-BMI and the METS-IR index showed significantly decreased odds ratio of 0.304 and 0.352, respectively, for OP with respect to its first quartile value. The area under the curve of TyG-BMI and the METS-IR index was 0.616 and 0.605, respectively. Conclusions: IR surrogates TyG-BMI and the METS-IR index were positively associated with BMD and may be protective factors for OP in Chinese non-diabetic postmenopausal women. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
目的: 本研究旨在探讨四种胰岛素抵抗(IR)替代指标与骨密度(BMD)之间的关系, 并评估这些指标是否可作为中国非糖尿病绝经后女性骨质疏松(OP)的风险因素。 方法: 计算四种非胰岛素依赖的IR替代指标, 包括甘油三酯葡萄糖指数(TyG)、甘油三酯葡萄糖体重指数(TyG-BMI)、甘油三酯(TG)/高密度脂蛋白胆固醇(HDL-C)比值以及胰岛素抵抗代谢评分(METS-IR)指数。所有受试者均接受双能X线吸收法(DXA)测量BMD。采用Pearson相关性分析评估IR指标与BMD的相关性, 随后通过逻辑回归分析探讨这些指标与OP的关系, 并使用受试者工作特征曲线(ROC曲线)评估其对OP的预测价值。 结果: TyG-BMI和METS-IR指数与BMD呈显著正相关。随着TyG-BMI和METS-IR指数的增加, OP的患病率下降。调整混杂因素后, TyG-BMI和METS-IR指数的第四四分位数相较于第一四分位数, OP的比值比(OR)分别显著降低至0.304和0.352。TyG-BMI和METS-IR指数的曲线下面积(AUC)分别为0.616和0.605。 结论: IR替代指标TyG-BMI和METS-IR指数与中国非糖尿病绝经后女性的BMD呈正相关, 可能是OP的保护因素。 [ABSTRACT FROM AUTHOR] |
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